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iGMDRD74

Canonical SMILES: CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O

InChI: InChI=1S/C26H27NO9/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3/t10-,15-,16-,17-,21+,26-/m0/s1

InChI Key: XDXDZDZNSLXDNA-TZNDIEGXSA-N

Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Idarubicin	CHEMBL1117 CHEMBL1200976	42890	D08062	DB01177	Alone	DAP000050	Small Molecule

Drug Class:

Anthracycline Topoisomerase Inhibitor Anthracyclines Anthracyclines and Related Substances Antibiotics, Antineoplastic Antineoplastic Agents Antineoplastic and Immunomodulating Agents Carbohydrates Cardiotoxic antineoplastic agents Cytochrome P-450 Enzyme Inhibitors Cytotoxic Antibiotics and Related Substances Daunorubicin Enzyme Inhibitors Glycosides Hydrocarbons Hydrocarbons, Aromatic Hydrocarbons, Cyclic Immunosuppressive Agents Myelosuppressive Agents Naphthacenes Polycyclic Compounds Polycyclic Hydrocarbons, Aromatic Topoisomerase II Inhibitors Topoisomerase Inhibitors

Drug Targets:

DNA TOP2A (P11388)

Drug Synonyms:

Idarubicin (INN)Zavedos (TN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	6
3696	ITGB8	1
64901	RANBP17	4
1105	CHD1	2
8999	CDKL2	2
6664	SOX11	1
5027	P2RX7	3
10903	MTMR11	3
10221	TRIB1	3
10641	NPRL2	1
132	ADK	3
11183	MAP4K5	4
79947	DHDDS	3
5546	PRCC	3
4168	MCF2	5
23513	SCRIB	2
2956	MSH6	4
150465	TTL	6
2339	FNTA	3
3708	ITPR1	4
10783	NEK6	3
1588	CYP19A1	2
7272	TTK	4
3845	KRAS	1
4750	NEK1	4
5295	PIK3R1	2
6351	CCL4	2
80070	ADAMTS20	2
701	BUB1B	2
3939	LDHA	6
5934	RBL2	2
79092	CARD14	2
3431	SP110	3
4352	MPL	3
6938	TCF12	2
1263	PLK3	4
9475	ROCK2	2
3551	IKBKB	3
4036	LRP2	2
10395	DLC1	3
5133	PDCD1	4
843	CASP10	3
3069	HDLBP	3
9530	BAG4	4
7444	VRK2	3
390502	SERPINA2	2
5079	PAX5	2
64783	RBM15	1
23235	SIK2	3
10863	ADAM28	3
6598	SMARCB1	3
4170	MCL1	1
3066	HDAC2	2
10142	AKAP9	1
23310	NCAPD3	4
2241	FER	3
341676	NEK5	3
57172	CAMK1G	3
9816	URB2	3
84299	MIEN1	2
6887	TAL2	5
51199	NIN	1
114783	LMTK3	1
202374	STK32A	5
1387	CREBBP	2
11329	STK38	3
5756	TWF1	1
10013	HDAC6	6
5579	PRKCB	2
51755	CDK12	3
5596	MAPK4	3
57472	CNOT6	3
5966	REL	4
3604	TNFRSF9	3
29998	BICRA	1
8295	TRRAP	2
1111	CHEK1	3
11122	PTPRT	3
9024	BRSK2	2
5396	PRRX1	6
7173	TPO	3
55294	FBXW7	2
2033	EP300	5
8030	CCDC6	3
641	BLM	2
10006	ABI1	2
5900	RALGDS	3
342977	NANOS3	1
7025	NR2F1	2
2051	EPHB6	2
3714	JAG2	2
32	ACACB	1
3556	IL1RAP	2
26353	HSPB8	3
22806	IKZF3	3
7416	VDAC1	3
22984	PDCD11	2
200576	PIKFYVE	2
8313	AXIN2	3
1050	CEBPA	3
199699	DAND5	3
51343	FZR1	2
114548	NLRP3	3
730249	ACOD1	6
10188	TNK2	5
51804	SIX4	3
3688	ITGB1	3
7088	TLE1	2
55681	SCYL2	2
2045	EPHA7	3
1992	SERPINB1	4
2064	ERBB2	1
83983	TSSK6	2
8643	PTCH2	1
8395	PIP5K1B	6
23191	CYFIP1	3
23387	SIK3	2
783	CACNB2	3
92	ACVR2A	1
5286	PIK3C2A	2
25989	ULK3	3
10087	COL4A3BP	3
5591	PRKDC	3
6464	SHC1	7
472	ATM	3
83903	HASPIN	1
53942	CNTN5	2
5924	RASGRF2	3
84433	CARD11	2
9564	BCAR1	2
4058	LTK	2
1123	CHN1	3
7533	YWHAH	3
5289	PIK3C3	3
23152	CIC	2
7867	MAPKAPK3	3
2066	ERBB4	3
839	CASP6	3
5863	RGL2	2
7184	HSP90B1	5
157753	TMEM74	2
9874	TLK1	3
28514	DLL1	3
3932	LCK	3
58508	KMT2C	2
6092	ROBO2	4
57194	ATP10A	3
8218	CLTCL1	3
836	CASP3	3
2263	FGFR2	1
7249	TSC2	2
105	ADARB2	2
863	CBFA2T3	5
1102	RCBTB2	2
55437	STRADB	4
2309	FOXO3	2
7038	TG	1
9965	FGF19	1
6197	RPS6KA3	3
55589	BMP2K	5
65125	WNK1	2
4436	MSH2	1
50945	TBX22	4
5650	KLK7	7
7175	TPR	2
80205	CHD9	1
4026	LPP	4
8997	KALRN	3
4437	MSH3	1
2071	ERCC3	3
23269	MGA	8
23469	PHF3	2
4089	SMAD4	1
6654	SOS1	3
672	BRCA1	4
256536	TCERG1L	3
9252	RPS6KA5	1
78989	COLEC11	1
23373	CRTC1	2
285220	EPHA6	2
51366	UBR5	9
3426	CFI	1
3417	IDH1	6
23678	SGK3	2
5606	MAP2K3	2
5297	PI4KA	1
6134	RPL10	3
5069	PAPPA	3
10535	RNASEH2A	3
57144	PAK5	2
4214	MAP3K1	2
1198	CLK3	5
9972	NUP153	3
2187	FANCB	2
5290	PIK3CA	1
92335	STRADA	3
6046	BRD2	2
3720	JARID2	3
1514	CTSL	3
2931	GSK3A	7
5034	P4HB	2
4145	MATK	3
26524	LATS2	2
5366	PMAIP1	3
2318	FLNC	3
57154	SMURF1	3
675	BRCA2	2
841	CASP8	3
2735	GLI1	2
3065	HDAC1	3
4609	MYC	1
64750	SMURF2	3
90956	ADCK2	3
2624	GATA2	4
8021	NUP214	3
90427	BMF	2
4684	NCAM1	2
6885	MAP3K7	3
26278	SACS	2
1440	CSF3	3
79759	ZNF668	2
5156	PDGFRA	3
375056	MIA3	2
27330	RPS6KA6	3
3949	LDLR	3
10186	LHFPL6	2
57082	KNL1	3
1213	CLTC	4
6011	GRK1	1
1769	DNAH8	3
1788	DNMT3A	1
22976	PAXIP1	2
23532	PRAME	5
4863	NPAT	5
8924	HERC2	6
120892	LRRK2	4
89795	NAV3	2
6095	RORA	4
146057	TTBK2	6
84441	MAML2	3
5205	ATP8B1	2
5128	CDK17	2
8178	ELL	3
664	BNIP3	5
4853	NOTCH2	4
3229	HOXC13	3
23598	PATZ1	2
23049	SMG1	6
10010	TANK	5
8312	AXIN1	1
7030	TFE3	1
4914	NTRK1	2
22883	CLSTN1	3
667	DST	1
1950	EGF	3
2264	FGFR4	3
177	AGER	1
5896	RAG1	3
8301	PICALM	3
6498	SKIL	3
1018	CDK3	3
7465	WEE1	6
10257	ABCC4	3
23389	MED13L	2
10562	OLFM4	3
55359	STYK1	3
29959	NRBP1	2
23411	SIRT1	3
387	RHOA	3
8821	INPP4B	2
221895	JAZF1	3
1643	DDB2	2
54738	FEV	3
558	AXL	3
9748	SLK	2
57680	CHD8	2
2869	GRK5	3
2317	FLNB	2
5395	PMS2	3
3181	HNRNPA2B1	3
9659	PDE4DIP	2
4000	LMNA	2
54101	RIPK4	3
6093	ROCK1	2
3557	IL1RN	5
5335	PLCG1	2
2130	EWSR1	2
131890	GRK7	3
5927	KDM5A	6
1385	CREB1	3
55007	FAM118A	2
1719	DHFR	4
5583	PRKCH	2
1975	EIF4B	3
57448	BIRC6	2
22982	DIP2C	2
79837	PIP4K2C	2
8899	PRPF4B	4
3984	LIMK1	2
4772	NFATC1	2
80216	ALPK1	1
7112	TMPO	3
4261	CIITA	3
170685	NUDT10	4
2122	MECOM	8
1760	DMPK	2
5087	PBX1	1
9894	TELO2	3
2903	GRIN2A	3
5925	RB1	2
63923	TNN	3
5324	PLAG1	2
2308	FOXO1	3
7508	XPC	4
4302	MLLT6	3
4638	MYLK	6
51364	ZMYND10	3
197259	MLKL	2
3716	JAK1	2
3488	IGFBP5	3
3480	IGF1R	2
23092	ARHGAP26	3
11086	ADAM29	3
2261	FGFR3	4
2073	ERCC5	3
79966	SCD5	2
1612	DAPK1	2
55791	LRIF1	2
9625	AATK	2
1840	DTX1	2
94	ACVRL1	3
2044	EPHA5	3
4593	MUSK	2
7294	TXK	3
6868	ADAM17	2
23112	TNRC6B	4
27255	CNTN6	4
1499	CTNNB1	7
56155	TEX14	4
4916	NTRK3	3
167359	NIM1K	3
5970	RELA	4
1488	CTBP2	4

Gene in drug-gene network: Network Plot

Models in Idarubicin

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.