SGK3

Summary: This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameserum/glucocorticoid regulated kinase family member 3
OMIM IDMIM:607591
Ensembl IDEnsembl:ENSG00000104205
HGNC IDHGNC:HGNC:10812
PHARMGKB IDPA35722
Map Location8q13.1

GO terms in SGK3


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0005769 early endosome
CC TAS GO:0005829 cytosol
CC IEA GO:0055037 recycling endosome
BP TAS GO:0001558 regulation of cell growth
BP TAS GO:0006468 protein phosphorylation
BP IBA GO:0018105 peptidyl-serine phosphorylation
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Gene expression in normal tissue: SGK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined24Proteasome1Cell cycle1p53 pathway1Apoptosis regulation1Longevity regulating pathway1

Pathways in SGK3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-2672351 Stimuli-sensing channels
reactome R-HSA-382551 Transport of small molecules
reactome R-HSA-983712 Ion channel transport
kegg hsa04068 FoxO signaling pathway - Homo sapiens (human)
kegg hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
wikipathways WP4172 PI3K-Akt Signaling Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD137 Indisulam 2
iGMDRD260 FQI-2 2
iGMDRD705 Nakiterpiosin 6
iGMDRD187 BRD9876 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SGK3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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