SGK3
Summary: This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serum/glucocorticoid regulated kinase family member 3 | MIM:607591 | Ensembl:ENSG00000104205 | HGNC:HGNC:10812 | PA35722 | 8q13.1 |
GO terms in SGK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005769 | early endosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0055037 | recycling endosome |
| BP | TAS | GO:0001558 | regulation of cell growth |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | TAS | GO:0030334 | regulation of cell migration |
| BP | TAS | GO:0034220 | ion transmembrane transport |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0042127 | regulation of cell proliferation |
| BP | TAS | GO:0051090 | regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0005246 | calcium channel regulator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0015459 | potassium channel regulator activity |
| MF | TAS | GO:0015459 | potassium channel regulator activity |
| MF | TAS | GO:0017080 | sodium channel regulator activity |
| MF | TAS | GO:0017081 | chloride channel regulator activity |
| MF | IEA | GO:0035091 | phosphatidylinositol binding |
Gene expression in normal tissue: SGK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SGK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-983712 | Ion channel transport |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD137 | Indisulam | 2 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD100 | Zebularine | 6 |
| iGMDRD887 | Compound 23 citrate | 5 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD398 | Sepantronium | 5 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD451 | Serdemetan | 4 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD484 | Pluripotin | 6 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD341 | Triacsin c | 6 |
| iGMDRD718 | Pyrvinium pamoate | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD152 | 179324-69-7 | 6 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD154 | NSC23766 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SGK3
CLASSFICATION
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