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iGMDRD345

Canonical SMILES: COC1=C(C=C(C=C1)Br)S(=O)(=O)NC(=O)C=CC2=C(C=CC(=C2)Cl)CC3=CC4=CC=CC=C4C=C3

InChI: InChI=1S/C27H21BrClNO4S/c1-34-25-12-10-23(28)17-26(25)35(32,33)30-27(31)13-9-22-16-24(29)11-8-21(22)15-18-6-7-19-4-2-3-5-20(19)14-18/h2-14,16-17H,15H2,1H3,(H,30,31)/b13-9+

InChI Key: DYXFUJYHEDGCLS-UKTHLTGXSA-N

Standard Name	Pubchem CID	Drug Status	Drug Type
Compound 10b [PMID: 11504634]	9808640	Alone	Small Molecule

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
3696	ITGB8	6
1105	CHD1	4
4854	NOTCH3	6
8019	BRD3	2
81037	CLPTM1L	6
10221	TRIB1	1
132	ADK	4
4627	MYH9	3
5546	PRCC	3
150465	TTL	6
347365	ITIH6	2
3845	KRAS	2
3757	KCNH2	2
5295	PIK3R1	2
23097	CDK19	3
6563	SLC14A1	2
8289	ARID1A	1
80070	ADAMTS20	5
25778	DSTYK	2
3551	IKBKB	3
9869	SETDB1	2
353345	GPR141	2
5133	PDCD1	2
79820	CATSPERB	2
56776	FMN2	1
10863	ADAM28	2
1136	CHRNA3	3
3841	KPNA5	2
2241	FER	4
57172	CAMK1G	3
112858	TP53RK	2
1387	CREBBP	1
55023	PHIP	6
5788	PTPRC	3
5596	MAPK4	1
57472	CNOT6	3
3604	TNFRSF9	2
10438	C1D	5
23617	TSSK2	5
6722	SRF	3
5396	PRRX1	6
7173	TPO	5
5314	PKHD1	5
51512	GTSE1	3
6927	HNF1A	3
9578	CDC42BPB	2
4361	MRE11	4
83439	TCF7L1	5
1454	CSNK1E	3
10006	ABI1	1
25925	ZNF521	3
5900	RALGDS	2
342977	NANOS3	3
2268	FGR	3
6256	RXRA	4
32	ACACB	2
3556	IL1RAP	5
2242	FES	3
7416	VDAC1	3
200576	PIKFYVE	5
1050	CEBPA	8
80129	CCDC170	1
10188	TNK2	2
11169	WDHD1	3
83990	BRIP1	1
51804	SIX4	5
7088	TLE1	2
284217	LAMA1	3
4982	TNFRSF11B	4
238	ALK	1
399979	SNX19	3
7078	TIMP3	6
2064	ERBB2	4
65266	WNK4	3
6663	SOX10	6
834	CASP1	6
1452	CSNK1A1	6
25989	ULK3	1
6709	SPTAN1	2
6464	SHC1	5
2778	GNAS	1
130497	OSR1	3
472	ATM	2
28996	HIPK2	3
5924	RASGRF2	2
9564	BCAR1	2
6792	CDKL5	3
1123	CHN1	7
898	CCNE1	3
7867	MAPKAPK3	2
5327	PLAT	2
5108	PCM1	3
5336	PLCG2	1
7157	TP53	3
57194	ATP10A	3
25836	NIPBL	1
4292	MLH1	2
105	ADARB2	2
9088	PKMYT1	3
55437	STRADB	2
6197	RPS6KA3	4
136332	LRGUK	4
5650	KLK7	1
54106	TLR9	3
80205	CHD9	2
2081	ERN1	3
8997	KALRN	2
4437	MSH3	2
23269	MGA	1
23469	PHF3	3
51284	TLR7	6
672	BRCA1	4
2668	GDNF	4
11168	PSIP1	2
23373	CRTC1	2
9448	MAP4K4	3
285220	EPHA6	2
51366	UBR5	1
23678	SGK3	1
10926	DBF4	2
10535	RNASEH2A	2
8216	LZTR1	1
286133	SCARA5	1
5290	PIK3CA	6
92335	STRADA	3
3720	JARID2	3
1514	CTSL	4
4293	MAP3K9	2
85366	MYLK2	3
2318	FLNC	7
675	BRCA2	3
607	BCL9	2
1459	CSNK2A2	4
90427	BMF	2
7297	TYK2	4
4684	NCAM1	2
283629	TSSK4	3
6776	STAT5A	4
79759	ZNF668	3
1594	CYP27B1	3
5156	PDGFRA	2
7443	VRK1	2
375056	MIA3	3
137872	ADHFE1	3
56924	PAK6	3
203102	ADAM32	4
7153	TOP2A	2
1981	EIF4G1	3
1213	CLTC	3
1769	DNAH8	3
22976	PAXIP1	2
4863	NPAT	5
780	DDR1	1
120892	LRRK2	1
65268	WNK2	3
6095	RORA	6
84441	MAML2	3
9113	LATS1	2
8178	ELL	3
4298	MLLT1	5
9321	TRIP11	6
8491	MAP4K3	3
4853	NOTCH2	3
8621	CDK13	3
23049	SMG1	2
10010	TANK	2
57521	RPTOR	4
7030	TFE3	3
5595	MAPK3	2
4914	NTRK1	3
22883	CLSTN1	3
667	DST	4
3554	IL1R1	3
2897	GRIK1	3
6146	RPL22	3
1950	EGF	2
2264	FGFR4	1
177	AGER	3
1676	DFFA	3
9344	TAOK2	2
3899	AFF3	4
79834	PEAK1	2
995	CDC25C	3
2277	VEGFD	2
29959	NRBP1	2
8821	INPP4B	2
5532	PPP3CB	2
8394	PIP5K1A	5
2353	FOS	4
1643	DDB2	3
2072	ERCC4	3
4619	MYH1	4
57680	CHD8	2
10111	RAD50	4
5395	PMS2	4
9659	PDE4DIP	6
54101	RIPK4	3
3557	IL1RN	3
2194	FASN	3
5927	KDM5A	6
55007	FAM118A	2
1719	DHFR	2
10734	STAG3	3
900	CCNG1	1
8317	CDC7	4
22982	DIP2C	4
3709	ITPR2	4
23301	EHBP1	2
3984	LIMK1	3
8428	STK24	2
2719	GPC3	2
80216	ALPK1	2
84072	HORMAD1	4
170685	NUDT10	1
182	JAG1	3
2122	MECOM	1
5087	PBX1	2
2903	GRIN2A	4
63923	TNN	4
3691	ITGB4	4
10420	TESK2	2
7403	KDM6A	1
1234	CCR5	2
7508	XPC	4
112268437	LOC112268437	6
4302	MLLT6	1
4638	MYLK	5
4205	MEF2A	2
2261	FGFR3	2
55422	ZNF331	2
57697	FANCM	2
57096	RPGRIP1	3
2044	EPHA5	2
5287	PIK3C2B	2
4593	MUSK	4
23683	PRKD3	3
1608	DGKG	2
1499	CTNNB1	2
2444	FRK	4
2892	GRIA3	5
2904	GRIN2B	2
5624	PROC	1

Gene in drug-gene network: Network Plot

Models in Compound 10b [PMID: 11504634]

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DATATYPES

CLASSFICATION

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