CHD1
Summary: The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| chromodomain helicase DNA binding protein 1 | MIM:602118 | Ensembl:ENSG00000153922 | HGNC:HGNC:1915 | PA26451 | 5q15-q21.1 |
GO terms in CHD1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006338 | chromatin remodeling |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0016569 | covalent chromatin modification |
| BP | IEA | GO:0032508 | DNA duplex unwinding |
| BP | IMP | GO:0043923 | positive regulation by host of viral transcription |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| MF | IEA | GO:0003677 | DNA binding |
| MF | TAS | GO:0004003 | ATP-dependent DNA helicase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0035064 | methylated histone binding |
| MF | IMP | GO:0035064 | methylated histone binding |
Gene expression in normal tissue: CHD1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHD1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD138 | PX 12 | 3 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD420 | Leucascandrolide A | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD105 | Triptolide | 4 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD246 | NPC26 | 4 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD150 | RITA | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD49 | Mitomycin | 3 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD698 | Neratinib | 1 |
| iGMDRD351 | GW843682X | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHD1
CLASSFICATION
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