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KCNH2

Summary: This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namepotassium voltage-gated channel subfamily H member 2 OMIM IDMIM:152427 Ensembl IDEnsembl:ENSG00000055118 HGNC IDHGNC:HGNC:6251 PHARMGKB IDPA212 Map Location7q36.1

Gene Categories:

DRUGGABLE GENOME DRUG RESISTANCE TRANSPORTER KINASE ION CHANNEL CELL SURFACE

GO terms in KCNH2

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0000160	phosphorelay signal transduction system
BP	TAS	GO:0003064	regulation of heart rate by hormone
BP	IEA	GO:0023014	signal transduction by protein phosphorylation
BP	IDA	GO:0035690	cellular response to drug
BP	IBA	GO:0042391	regulation of membrane potential
BP	IDA	GO:0042391	regulation of membrane potential

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Gene expression in normal tissue: KCNH2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KCNH2

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-112316	Neuronal System
reactome	R-HSA-1296071	Potassium Channels
reactome	R-HSA-1296072	Voltage gated Potassium channels
reactome	R-HSA-397014	Muscle contraction
reactome	R-HSA-5576890	Phase 3 - rapid repolarisation
reactome	R-HSA-5576891	Cardiac conduction

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD158	NSC141540	2
iGMDRD137	Indisulam	2
iGMDRD121	GMX1778	2
iGMDRD267	Oligomycin A	4

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KCNH2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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