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iGMDRD474

Canonical SMILES: CC1(C=CC2=C(O1)C=CC3=C2[N+](=C4C3=CC56C(C4(C)C)CC7(CCCN7C5=O)C(=O)N6)[O-])C

InChI: InChI=1S/C26H27N3O4/c1-23(2)10-8-15-17(33-23)7-6-14-16-12-26-18(24(3,4)20(16)29(32)19(14)15)13-25(21(30)27-26)9-5-11-28(25)22(26)31/h6-8,10,12,18H,5,9,11,13H2,1-4H3,(H,27,30)/t18-,25-,26-/m0/s1

InChI Key: ALXLLOQTGLPCFG-ATANMQQVSA-N

Standard Name	Pubchem CID	Drug Status	Drug Type
Avrainvillamide	11719300	Alone	Small Molecule

Drug Targets:

NPM1

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
3696	ITGB8	3
6664	SOX11	3
7074	TIAM1	1
471	ATIC	1
79848	CSPP1	2
7837	PXDN	9
7128	TNFAIP3	1
8444	DYRK3	3
6774	STAT3	2
7161	TP73	1
4926	NUMA1	2
3708	ITPR1	2
3757	KCNH2	2
8289	ARID1A	4
51231	VRK3	1
2335	FN1	3
5593	PRKG2	2
4312	MMP1	3
2475	MTOR	6
9475	ROCK2	2
6597	SMARCA4	3
3326	HSP90AB1	3
4036	LRP2	2
8780	RIOK3	3
10395	DLC1	2
10320	IKZF1	2
7444	VRK2	2
7942	TFEB	2
56776	FMN2	2
23235	SIK2	1
9891	NUAK1	2
4170	MCL1	1
1607	DGKB	1
22853	LMTK2	2
7253	TSHR	6
3841	KPNA5	10
55534	MAML3	5
7048	TGFBR2	4
202374	STK32A	5
1387	CREBBP	6
7555	CNBP	3
2885	GRB2	6
56164	STK31	5
4283	CXCL9	2
31	ACACA	3
51755	CDK12	3
29998	BICRA	2
26576	SRPK3	1
5899	RALB	1
5159	PDGFRB	6
55300	PI4K2B	3
5314	PKHD1	3
974	CD79B	2
10295	BCKDK	3
8784	TNFRSF18	2
1454	CSNK1E	3
4595	MUTYH	1
7852	CXCR4	3
54477	PLEKHA5	2
284521	OR2L13	5
4610	MYCL	2
5900	RALGDS	3
256646	NUTM1	3
9693	RAPGEF2	3
1586	CYP17A1	3
1591	CYP24A1	1
8852	AKAP4	1
3556	IL1RAP	2
2688	GH1	3
64083	GOLPH3	2
2242	FES	2
10342	TFG	3
4005	LMO2	2
3645	INSRR	3
22984	PDCD11	1
200576	PIKFYVE	3
8313	AXIN2	3
2042	EPHA3	3
23255	MTCL1	3
10188	TNK2	2
9636	ISG15	5
4216	MAP3K4	1
6198	RPS6KB1	1
51804	SIX4	2
9098	USP6	2
6928	HNF1B	3
388581	C1QTNF12	7
83931	STK40	2
2045	EPHA7	4
1992	SERPINB1	3
7078	TIMP3	1
375449	MAST4	1
7428	VHL	2
22858	ICK	2
2064	ERBB2	5
3916	LAMP1	3
23191	CYFIP1	1
23387	SIK3	4
9131	AIFM1	2
9759	HDAC4	1
158056	MAMDC4	2
10087	COL4A3BP	3
80312	TET1	3
6037	RNASE3	1
9472	AKAP6	5
6917	TCEA1	5
472	ATM	3
8945	BTRC	2
139285	AMER1	5
53942	CNTN5	1
9564	BCAR1	5
4804	NGFR	3
11344	TWF2	3
2050	EPHB4	3
2272	FHIT	3
7681	MKRN3	1
904	CCNT1	4
1647	GADD45A	4
5863	RGL2	3
51517	NCKIPSD	3
2201	FBN2	4
10062	NR1H3	2
139728	PNCK	3
5129	CDK18	2
58508	KMT2C	1
648	BMI1	3
7157	TP53	2
4602	MYB	2
6794	STK11	4
2329	FMO4	1
356	FASLG	3
114788	CSMD3	3
54498	SMOX	1
2133	EXT3	3
85481	PSKH2	3
4869	NPM1	2
863	CBFA2T3	6
7422	VEGFA	3
3572	IL6ST	4
57188	ADAMTSL3	3
65125	WNK1	2
57591	MRTFA	2
6035	RNASE1	3
6535	SLC6A8	1
984	CDK11B	2
7175	TPR	7
80205	CHD9	2
23365	ARHGEF12	3
84181	CHD6	1
10499	NCOA2	5
170692	ADAMTS18	3
7471	WNT1	1
6654	SOS1	5
672	BRCA1	2
11168	PSIP1	3
256536	TCERG1L	2
139760	GPR119	5
23373	CRTC1	3
5727	PTCH1	3
5606	MAP2K3	7
2047	EPHB1	1
10926	DBF4	1
30827	CXXC1	1
5578	PRKCA	2
4214	MAP3K1	1
3702	ITK	2
9972	NUP153	5
3239	HOXD13	3
50615	IL21R	3
5290	PIK3CA	4
4145	MATK	6
85366	MYLK2	3
64919	BCL11B	3
5530	PPP3CA	2
4803	NGF	1
1956	EGFR	1
8445	DYRK2	1
157680	VPS13B	4
2735	GLI1	4
5789	PTPRD	5
5155	PDGFB	4
26278	SACS	4
896	CCND3	5
29951	PDZRN4	1
6776	STAT5A	1
6446	SGK1	2
1022	CDK7	3
7132	TNFRSF1A	2
7189	TRAF6	9
4790	NFKB1	5
84879	MFSD2A	5
1769	DNAH8	2
5781	PTPN11	2
23532	PRAME	4
4863	NPAT	4
780	DDR1	3
8924	HERC2	2
6469	SHH	1
6502	SKP2	3
998	CDC42	1
89795	NAV3	9
65268	WNK2	2
6095	RORA	4
29844	TFPT	6
1677	DFFB	1
84441	MAML2	2
7301	TYRO3	9
7468	NSD2	4
8178	ELL	3
5294	PIK3CG	2
5979	RET	3
9321	TRIP11	1
10253	SPRY2	9
9451	EIF2AK3	1
9509	ADAMTS2	2
8621	CDK13	3
23742	NPAP1	2
8312	AXIN1	2
57521	RPTOR	3
7030	TFE3	4
1613	DAPK3	2
6770	STAR	3
7273	TTN	2
91807	MYLK3	1
6789	STK4	3
23389	MED13L	1
2277	VEGFD	3
54904	NSD3	3
79012	CAMKV	4
8805	TRIM24	1
65018	PINK1	3
1662	DDX10	2
10595	ERN2	4
5588	PRKCQ	9
5291	PIK3CB	2
3611	ILK	1
4923	NTSR1	3
7248	TSC1	3
126792	B3GALT6	2
5581	PRKCE	1
1399	CRKL	1
2690	GHR	6
5395	PMS2	1
5609	MAP2K7	1
152110	NEK10	1
1281	COL3A1	3
9201	DCLK1	2
7293	TNFRSF4	8
283455	KSR2	2
2776	GNAQ	1
3624	INHBA	2
4628	MYH10	1
3579	CXCR2	6
4215	MAP3K3	3
57448	BIRC6	6
57007	ACKR3	3
5681	PSKH1	1
2304	FOXE1	2
8317	CDC7	3
2157	F8	4
5506	PPP1R3A	5
6778	STAT6	2
1906	EDN1	4
6194	RPS6	1
8428	STK24	8
51562	MBIP	3
330	BIRC3	3
84072	HORMAD1	1
23512	SUZ12	1
444	ASPH	3
7046	TGFBR1	2
2122	MECOM	1
2065	ERBB3	6
3691	ITGB4	6
4439	MSH5	3
2534	FYN	2
5586	PKN2	3
55959	SULF2	3
3480	IGF1R	4
10494	STK25	3
55869	HDAC8	6
4299	AFF1	3
11086	ADAM29	3
142	PARP1	6
3092	HIP1	1
55746	NUP133	1
595	CCND1	3
2280	FKBP1A	1
4629	MYH11	1
30811	HUNK	4
6943	TCF21	5
1608	DGKG	1
699	BUB1	2
4193	MDM2	2
23112	TNRC6B	3
29110	TBK1	1
27151	CPAMD8	2
1436	CSF1R	6
4916	NTRK3	3
11035	RIPK3	3
4486	MST1R	3
5624	PROC	3

Gene in drug-gene network: Network Plot

Models in Avrainvillamide

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.