FMO4
Summary: Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:136131 Ensembl IDEnsembl:ENSG00000076258 HGNC IDHGNC:HGNC:3772 PHARMGKB IDPA28188 Map Location1q24.3 | |||||
GO terms in FMO4
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0042737 | drug catabolic process |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031090 | organelle membrane |
| MF | IBA | GO:0004497 | monooxygenase activity |
| MF | NAS | GO:0004499 | N,N-dimethylaniline monooxygenase activity |
Gene expression in normal tissue: FMO4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FMO4
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165374494 | Busulfan Pathway, Pharmacodynamics |
| kegg | hsa00982 | Drug metabolism - cytochrome P450 - Homo sapiens (human) |
| humancyc | PWY66-201 | nicotine degradation IV |
| wikipathways | WP688 | Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FMO4
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.