FMO4
Summary: Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| flavin containing monooxygenase 4 | MIM:136131 | Ensembl:ENSG00000076258 | HGNC:HGNC:3772 | PA28188 | 1q24.3 |
GO terms in FMO4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0042737 | drug catabolic process |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031090 | organelle membrane |
| MF | IBA | GO:0004497 | monooxygenase activity |
| MF | NAS | GO:0004499 | N,N-dimethylaniline monooxygenase activity |
| MF | IEA | GO:0050660 | flavin adenine dinucleotide binding |
| MF | IEA | GO:0050661 | NADP binding |
Gene expression in normal tissue: FMO4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FMO4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165374494 | Busulfan Pathway, Pharmacodynamics |
| kegg | hsa00982 | Drug metabolism - cytochrome P450 - Homo sapiens (human) |
| humancyc | PWY66-201 | nicotine degradation IV |
| wikipathways | WP688 | Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD599 | Salermide | 5 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD270 | Ciclosporin | 4 |
| iGMDRD298 | L-685458 | 3 |
| iGMDRD318 | PAC-1 | 8 |
| iGMDRD415 | LE-135 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FMO4
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