DAPK3
Summary: Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| death associated protein kinase 3 | MIM:603289 | Ensembl:ENSG00000167657 | HGNC:HGNC:2676 | PA27144 | 19p13.3 |
GO terms in DAPK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006325 | chromatin organization |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | IMP | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006940 | regulation of smooth muscle contraction |
| BP | TAS | GO:0007088 | regulation of mitotic nuclear division |
| BP | IMP | GO:0007346 | regulation of mitotic cell cycle |
| BP | IEA | GO:0008360 | regulation of cell shape |
| BP | TAS | GO:0010506 | regulation of autophagy |
| BP | IDA | GO:0017148 | negative regulation of translation |
| BP | IEA | GO:0030182 | neuron differentiation |
| BP | IEA | GO:0030335 | positive regulation of cell migration |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:0042981 | regulation of apoptotic process |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043519 | regulation of myosin II filament organization |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | TAS | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0051893 | regulation of focal adhesion assembly |
| BP | IDA | GO:0071346 | cellular response to interferon-gamma |
| BP | IMP | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:0097190 | apoptotic signaling pathway |
| BP | TAS | GO:2000145 | regulation of cell motility |
| BP | IDA | GO:2000249 | regulation of actin cytoskeleton reorganization |
| BP | TAS | GO:2000249 | regulation of actin cytoskeleton reorganization |
| BP | IEA | GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005884 | actin filament |
| CC | IEA | GO:0016605 | PML body |
| CC | IEA | GO:0045121 | membrane raft |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005524 | ATP binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008022 | protein C-terminus binding |
| MF | TAS | GO:0008140 | cAMP response element binding protein binding |
| MF | IDA | GO:0017048 | Rho GTPase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0043522 | leucine zipper domain binding |
Gene expression in normal tissue: DAPK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DAPK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-418889 | via Dependence Receptors in the absence of ligand |
| reactome | R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| wikipathways | WP2828 | Bladder Cancer |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD781 | Sirolimus | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DAPK3
CLASSFICATION
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