TBK1

Summary: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameTANK binding kinase 1
OMIM IDMIM:604834
Ensembl IDEnsembl:ENSG00000183735
HGNC IDHGNC:HGNC:11584
PHARMGKB IDPA36348
Map Location12q14.2

GO terms in TBK1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005654 nucleoplasm
CC IBA GO:0005737 cytoplasm
CC IDA GO:0005737 cytoplasm
CC TAS GO:0005829 cytosol
CC TAS GO:0010008 endosome membrane
CC IDA GO:0016235 aggresome
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Gene expression in normal tissue: TBK1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 27undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 12BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 8LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 4SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Melanoma (MEL) model num: 2

Gene-drug pathway distribution

undefined17Apoptosis regulation2ERK MAPK signaling1Longevity regulating pathway1IGFR signaling1Protein stability and degradation1

Pathways in TBK1


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Database
Pathway ID
Pathway Des.
netpath Pathway_TNFalpha TNFalpha
kegg hsa04014 Ras signaling pathway - Homo sapiens (human)
kegg hsa04137 Mitophagy - animal - Homo sapiens (human)
kegg hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
kegg hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
kegg hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD330 BRD4132 2
iGMDRD512 nutlin 3 5
iGMDRD546 BMS-754807 2
iGMDRD781 Sirolimus 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

8undefined1Procaspase-31ATP5L21MAP2K21BCL2L21HMGCS11CASP61HSP901NPM11IR

Gene Structure: PDB

Models in TBK1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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