TBK1
Summary: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TANK binding kinase 1 | MIM:604834 | Ensembl:ENSG00000183735 | HGNC:HGNC:11584 | PA36348 | 12q14.2 |
GO terms in TBK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0010008 | endosome membrane |
| CC | IDA | GO:0016235 | aggresome |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0009615 | response to virus |
| BP | IEA | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0016239 | positive regulation of macroautophagy |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | TAS | GO:0032479 | regulation of type I interferon production |
| BP | TAS | GO:0032480 | negative regulation of type I interferon production |
| BP | TAS | GO:0032481 | positive regulation of type I interferon production |
| BP | TAS | GO:0032606 | type I interferon production |
| BP | IDA | GO:0032727 | positive regulation of interferon-alpha production |
| BP | IDA | GO:0032728 | positive regulation of interferon-beta production |
| BP | NAS | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | TAS | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0044565 | dendritic cell proliferation |
| BP | TAS | GO:0045087 | innate immune response |
| BP | IEA | GO:0045359 | positive regulation of interferon-beta biosynthetic process |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0050830 | defense response to Gram-positive bacterium |
| BP | IEA | GO:0051607 | defense response to virus |
| BP | TAS | GO:0071345 | cellular response to cytokine stimulus |
| BP | NAS | GO:1901214 | regulation of neuron death |
| BP | IEA | GO:1904417 | positive regulation of xenophagy |
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0051219 | phosphoprotein binding |
Gene expression in normal tissue: TBK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TBK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP3851 | TLR4 Signaling and Tolerance |
| wikipathways | WP3858 | Toll-like Receptor Signaling |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs |
| reactome | R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs |
| reactome | R-HSA-1606341 | IRF3 mediated activation of type 1 IFN |
| reactome | R-HSA-1606341 | IRF3 mediated activation of type 1 IFN |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-1834941 | STING mediated induction of host immune responses |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-3134975 | Regulation of innate immune responses to cytosolic DNA |
| reactome | R-HSA-3249367 | STAT6-mediated induction of chemokines |
| reactome | R-HSA-3270619 | IRF3-mediated induction of type I IFN |
| reactome | R-HSA-446652 | Interleukin-1 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-9008059 | Interleukin-37 signaling |
| reactome | R-HSA-9013973 | TICAM1-dependent activation of IRF3/IRF7 |
| reactome | R-HSA-918233 | TRAF3-dependent IRF activation pathway |
| reactome | R-HSA-933541 | TRAF6 mediated IRF7 activation |
| reactome | R-HSA-936440 | Negative regulators of DDX58/IFIH1 signaling |
| reactome | R-HSA-936964 | Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD523 | Cyanoquinoline, 11 | 4 |
| iGMDRD799 | AZ909 | 1 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD309 | 17AAG | 2 |
| iGMDRD267 | Oligomycin A | 7 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD268 | Cerulenin | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TBK1
CLASSFICATION
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