TRIM24
Summary: The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tripartite motif containing 24 | MIM:603406 | Ensembl:ENSG00000122779 | HGNC:HGNC:11812 | PA36519 | 7q33-q34 |
GO terms in TRIM24
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005719 | nuclear euchromatin |
| CC | IEA | GO:0005726 | perichromatin fibrils |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IMP | GO:0030163 | protein catabolic process |
| BP | IMP | GO:0031647 | regulation of protein stability |
| BP | IMP | GO:0042981 | regulation of apoptotic process |
| BP | IEA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0055074 | calcium ion homeostasis |
| BP | IEA | GO:0070562 | regulation of vitamin D receptor signaling pathway |
| BP | IDA | GO:0071391 | cellular response to estrogen stimulus |
| BP | IEA | GO:1901796 | regulation of signal transduction by p53 class mediator |
| MF | IPI | GO:0002039 | p53 binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0016922 | nuclear receptor binding |
| MF | IDA | GO:0034056 | estrogen response element binding |
| MF | IDA | GO:0035064 | methylated histone binding |
| MF | IEA | GO:0061630 | ubiquitin protein ligase activity |
| MF | IDA | GO:0070577 | lysine-acetylated histone binding |
Gene expression in normal tissue: TRIM24
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIM24
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
| biocarta | wnvpathway | west nile virus |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD202 | Curcumin | 2 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD121 | GMX1778 | 6 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD874 | BRD8958 | 1 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD322 | FK 866 | 5 |
| iGMDRD640 | CAY10618 | 3 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD299 | ICL 670 | 2 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD466 | Chaetocin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIM24
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