PXDN
Summary: This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameperoxidasin OMIM IDMIM:605158 Ensembl IDEnsembl:ENSG00000130508 HGNC IDHGNC:HGNC:14966 PHARMGKB IDPA128394535 Map Location2p25.3 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in PXDN
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004601 | peroxidase activity |
| MF | IDA | GO:0004601 | peroxidase activity |
| MF | TAS | GO:0004601 | peroxidase activity |
| MF | NAS | GO:0005152 | interleukin-1 receptor antagonist activity |
| MF | IDA | GO:0005201 | extracellular matrix structural constituent |
| MF | IDA | GO:0020037 | heme binding |
Gene expression in normal tissue: PXDN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PXDN
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PXDN
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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