PXDN


Summary: This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
peroxidasinMIM:605158Ensembl:ENSG00000130508HGNC:HGNC:14966PA1283945352p25.3

Gene Categories:

DRUGGABLE GENOME

GO terms in PXDN


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004601peroxidase activity
MFIDAGO:0004601peroxidase activity
MFTASGO:0004601peroxidase activity
MFNASGO:0005152interleukin-1 receptor antagonist activity
MFIDAGO:0005201extracellular matrix structural constituent
MFIDAGO:0020037heme binding
MFIEAGO:0046872metal ion binding
BPIEAGO:0001960negative regulation of cytokine-mediated signaling pathway
BPNASGO:0006955immune response
BPIEAGO:0006979response to oxidative stress
BPIDAGO:0030198extracellular matrix organization
BPIDAGO:0042744hydrogen peroxide catabolic process
BPIDAGO:0055114oxidation-reduction process
BPIEAGO:0098869cellular oxidant detoxification
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0031012extracellular matrix
CCHDAGO:0062023collagen-containing extracellular matrix
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: PXDN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PXDN


DatabasePathway IDPathway Des.
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2006miR-targeted genes in squamous cell - TarBase
wikipathwaysWP437EGF-EGFR Signaling Pathway
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474290Collagen formation
reactomeR-HSA-2022090Assembly of collagen fibrils and other multimeric structures
reactomeR-HSA-2243919Crosslinking of collagen fibrils

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD152179324-69-72
iGMDRD61Kinetin riboside4
iGMDRD494Neopeltolide3
iGMDRD483SCH-5290741
iGMDRD427ABT7376
iGMDRD889Compound 7d-cis2
iGMDRD229B021
iGMDRD420Leucascandrolide A3
iGMDRD506Fedratinib1
iGMDRD577BIX012943
iGMDRD562Navitoclax4
iGMDRD188Piperlongumine2
iGMDRD318PAC-17
iGMDRD782DC-45-A24
iGMDRD255SB2250023
iGMDRD8024-methylfasudil1
iGMDRD270Ciclosporin5
iGMDRD474Avrainvillamide9
iGMDRD945ML2145
iGMDRD435BI-25366
iGMDRD883CIL55A1
iGMDRD314Tanespimycin1
iGMDRD351GW843682X4
iGMDRD499PDMP2
iGMDRD219Bax channel blocker2
iGMDRD341Triacsin c1
iGMDRD116CD4373
iGMDRD150RITA2
iGMDRD424Tamatinib2
iGMDRD512nutlin 39
iGMDRD353PD03259012
iGMDRD42Vorinostat3
iGMDRD505Pevonedistat3
iGMDRD886Compound 1541A7
iGMDRD552AZD-17756
iGMDRD871BRD63685
iGMDRD414MST-3122
iGMDRD872BRD71373
iGMDRD481Dactolisib2
iGMDRD77Itraconazole3
iGMDRD289Parthenolide1
iGMDRD6AM-5802
iGMDRD105Triptolide5
iGMDRD434BMS-5369246

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PXDN

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