HDAC4
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| histone deacetylase 4 | MIM:605314 | Ensembl:ENSG00000068024 | HGNC:HGNC:14063 | PA29229 | 2q37.3 |
GO terms in HDAC4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0001085 | RNA polymerase II transcription factor binding |
| MF | IEA | GO:0003714 | transcription corepressor activity |
| MF | IDA | GO:0004407 | histone deacetylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0030955 | potassium ion binding |
| MF | IEA | GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) |
| MF | IDA | GO:0033558 | protein deacetylase activity |
| MF | TAS | GO:0033558 | protein deacetylase activity |
| MF | IPI | GO:0033613 | activating transcription factor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IPI | GO:0070491 | repressing transcription factor binding |
| MF | IEA | GO:1990841 | promoter-specific chromatin binding |
| CC | IDA | GO:0000118 | histone deacetylase complex |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0017053 | transcriptional repressor complex |
| CC | IEA | GO:0030018 | Z disc |
| CC | IEA | GO:0031594 | neuromuscular junction |
| CC | IEA | GO:0031672 | A band |
| CC | IEA | GO:0042641 | actomyosin |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IGI | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001501 | skeletal system development |
| BP | IEA | GO:0002076 | osteoblast development |
| BP | IDA | GO:0006338 | chromatin remodeling |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006476 | protein deacetylation |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007399 | nervous system development |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0010592 | positive regulation of lamellipodium assembly |
| BP | IMP | GO:0010832 | negative regulation of myotube differentiation |
| BP | IEA | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling |
| BP | ISS | GO:0014894 | response to denervation involved in regulation of muscle adaptation |
| BP | TAS | GO:0014898 | cardiac muscle hypertrophy in response to stress |
| BP | IEA | GO:0014911 | positive regulation of smooth muscle cell migration |
| BP | IDA | GO:0016575 | histone deacetylation |
| BP | IMP | GO:0016575 | histone deacetylation |
| BP | TAS | GO:0030183 | B cell differentiation |
| BP | IDA | GO:0033235 | positive regulation of protein sumoylation |
| BP | IDA | GO:0034983 | peptidyl-lysine deacetylation |
| BP | IMP | GO:0040029 | regulation of gene expression, epigenetic |
| BP | TAS | GO:0042113 | B cell activation |
| BP | IEA | GO:0042493 | response to drug |
| BP | IMP | GO:0043393 | regulation of protein binding |
| BP | IMP | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IEA | GO:0045668 | negative regulation of osteoblast differentiation |
| BP | ISS | GO:0045820 | negative regulation of glycolytic process |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0048742 | regulation of skeletal muscle fiber development |
| BP | IMP | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IMP | GO:0070555 | response to interleukin-1 |
| BP | IDA | GO:0070932 | histone H3 deacetylation |
| BP | IDA | GO:0070933 | histone H4 deacetylation |
| BP | IEA | GO:0071260 | cellular response to mechanical stimulus |
| BP | IEA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IEA | GO:0071374 | cellular response to parathyroid hormone stimulus |
| BP | IEA | GO:1902894 | negative regulation of pri-miRNA transcription by RNA polymerase II |
| BP | IEA | GO:1903428 | positive regulation of reactive oxygen species biosynthetic process |
Gene expression in normal tissue: HDAC4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HDAC4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | ranbp2pathway | sumoylation by ranbp2 regulates transcriptional repression |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4090294 | SUMOylation of intracellular receptors |
| reactome | R-HSA-4551638 | SUMOylation of chromatin organization proteins |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8941284 | RUNX2 regulates chondrocyte maturation |
| reactome | R-HSA-8941326 | RUNX2 regulates bone development |
| reactome | R-HSA-8951936 | RUNX3 regulates p14-ARF |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP1992 | TarBasePathway |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| wikipathways | WP3878 | ATM Signaling Network in Development and Disease |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3996 | Ethanol effects on histone modifications |
| wikipathways | WP474 | Endochondral Ossification |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| pid | hdac_classii_pathway | Signaling events mediated by HDAC Class II |
| pid | hdac_classiii_pathway | Signaling events mediated by HDAC Class III |
| pid | ranbp2pathway | Sumoylation by RanBP2 regulates transcriptional repression |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD886 | Compound 1541A | 1 |
| iGMDRD246 | NPC26 | 7 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD607 | Ubistatin B | 1 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD84 | Lovastatin acid | 4 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD219 | Bax channel blocker | 2 |
| iGMDRD49 | Mitomycin | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD435 | BI-2536 | 4 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD613 | CHEMBL258148 | 1 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD780 | PP-30 | 4 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD546 | BMS-754807 | 4 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD193 | Fqi1 | 5 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD107 | Valdecoxib | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD394 | BX-795 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HDAC4
CLASSFICATION
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