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iGMDRD49

Canonical SMILES: CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N

InChI: InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1

InChI Key: NWIBSHFKIJFRCO-WUDYKRTCSA-N

Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Mitomycin	CHEMBL105	5746	D00208	DB00305	Alone	DAP001402	Small Molecule

Drug Class:

Alkylating Agents Alkylating Drug Antibiotics, Antineoplastic Antineoplastic Agents Antineoplastic and Immunomodulating Agents Azirines Cardiotoxic antineoplastic agents Cross-Linking Reagents Cytotoxic Antibiotics and Related Substances Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Heterocyclic Compounds, 2-Ring Immunosuppressive Agents Indicators and Reagents Indolequinones Indoles Laboratory Chemicals Mitomycins Myelosuppressive Agents Noxae Nucleic Acid Synthesis Inhibitors P-glycoprotein/ABCB1 Substrates Quinones Specialty Uses of Chemicals Toxic Actions

Drug Targets:

DNA crosslinker

Drug Pathways:

DNA replication Biosynthesis of antibiotics

Drug Synonyms:

Mitomycin (USP/INN)Mitomycin C (JP17)MMC Mitomycin (TN)Muamycin (TN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
1105	CHD1	3
2956	MSH6	1
6597	SMARCA4	1
2176	FANCC	1
390502	SERPINA2	1
10476	ATP5PD	1
5605	MAP2K2	1
54477	PLEKHA5	2
23012	STK38L	1
1776	DNASE1L3	1
6416	MAP2K4	1
9759	HDAC4	2
1029	CDKN2A	1
3932	LCK	1
7157	TP53	7
4086	SMAD1	1
4026	LPP	2
675	BRCA2	1
4609	MYC	1
3338	DNAJC4	1
23742	NPAP1	3
2317	FLNB	3
5506	PPP1R3A	2
5925	RB1	1
862	RUNX1T1	2
5586	PKN2	2
3488	IGFBP5	1
79728	PALB2	4
1803	DPP4	1
2886	GRB7	3

Gene in drug-gene network: Network Plot

Models in Mitomycin

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.