MSH6


Summary: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mutS homolog 6MIM:600678Ensembl:ENSG00000116062HGNC:HGNC:7329PA1842p16.3

GO terms in MSH6


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000287magnesium ion binding
MFIBAGO:0000400four-way junction DNA binding
MFIDAGO:0000400four-way junction DNA binding
MFIEAGO:0003682chromatin binding
MFIBAGO:0003684damaged DNA binding
MFIDAGO:0003690double-stranded DNA binding
MFIPIGO:0005515protein binding
MFIPIGO:0005515protein binding
MFIBAGO:0005524ATP binding
MFIDAGO:0005524ATP binding
MFIBAGO:0008094DNA-dependent ATPase activity
MFIDAGO:0016887ATPase activity
MFIBAGO:0030983mismatched DNA binding
MFIDAGO:0030983mismatched DNA binding
MFIDAGO:0030983mismatched DNA binding
MFIBAGO:0032137guanine/thymine mispair binding
MFIDAGO:0032137guanine/thymine mispair binding
MFIBAGO:0032138single base insertion or deletion binding
MFIDAGO:0032142single guanine insertion binding
MFIBAGO:0032143single thymine insertion binding
MFIDAGO:0032143single thymine insertion binding
MFIDAGO:0032357oxidized purine DNA binding
MFIBAGO:0032405MutLalpha complex binding
MFIDAGO:0032405MutLalpha complex binding
MFIBAGO:0035064methylated histone binding
MFIDAGO:0035064methylated histone binding
MFIPIGO:0042803protein homodimerization activity
MFIBAGO:0043531ADP binding
MFIDAGO:0043531ADP binding
BPIBAGO:0000710meiotic mismatch repair
BPISSGO:0000710meiotic mismatch repair
BPIDAGO:0006281DNA repair
BPIBAGO:0006290pyrimidine dimer repair
BPIBAGO:0006298mismatch repair
BPIDAGO:0006298mismatch repair
BPIGIGO:0006298mismatch repair
BPIMPGO:0006298mismatch repair
BPTASGO:0006298mismatch repair
BPIBAGO:0007095mitotic G2 DNA damage checkpoint
BPIBAGO:0008340determination of adult lifespan
BPISSGO:0008340determination of adult lifespan
BPIBAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPISSGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIBAGO:0009411response to UV
BPISSGO:0009411response to UV
BPIEAGO:0016032viral process
BPIBAGO:0016446somatic hypermutation of immunoglobulin genes
BPISSGO:0016446somatic hypermutation of immunoglobulin genes
BPISSGO:0016447somatic recombination of immunoglobulin gene segments
BPIBAGO:0030890positive regulation of B cell proliferation
BPIBAGO:0032876negative regulation of DNA endoreduplication
BPIBAGO:0036297interstrand cross-link repair
BPIBAGO:0043111replication fork arrest
BPIBAGO:0043570maintenance of DNA repeat elements
BPIMPGO:0043570maintenance of DNA repeat elements
BPIBAGO:0045190isotype switching
BPISSGO:0045190isotype switching
BPIBAGO:0045830positive regulation of isotype switching
BPIEAGO:0045830positive regulation of isotype switching
BPIBAGO:0045910negative regulation of DNA recombination
BPIDAGO:0045910negative regulation of DNA recombination
BPIBAGO:0051096positive regulation of helicase activity
BPIDAGO:0051096positive regulation of helicase activity
BPISSGO:0097193intrinsic apoptotic signaling pathway
CCIEAGO:0000790nuclear chromatin
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005829cytosol
CCIBAGO:0032300mismatch repair complex
CCIBAGO:0032301MutSalpha complex
CCIDAGO:0032301MutSalpha complex
CCIDAGO:0043231intracellular membrane-bounded organelle

Gene expression in normal tissue: MSH6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MSH6


DatabasePathway IDPathway Des.
reactomeR-HSA-1643685Disease
reactomeR-HSA-5358508Mismatch Repair
reactomeR-HSA-5358565Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
reactomeR-HSA-5423599Diseases of Mismatch Repair (MMR)
reactomeR-HSA-5632928Defective Mismatch Repair Associated With MSH2
reactomeR-HSA-5632968Defective Mismatch Repair Associated With MSH6
reactomeR-HSA-73894DNA Repair
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP531Mismatch repair
kegghsa03430Mismatch repair - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD49Mitomycin1
iGMDRD703KPT1851
iGMDRD532Olaparib1
iGMDRD366PI-1031
iGMDRD329Merck601
iGMDRD286Nsc 6328394
iGMDRD526KX2-3911
iGMDRD156HLI-3731
iGMDRD706BRD-K139994671
iGMDRD105Triptolide2
iGMDRD705Nakiterpiosin4
iGMDRD152179324-69-71
iGMDRD420Leucascandrolide A3
iGMDRD151CHM-13
iGMDRD126Tipifarnib2
iGMDRD283Bosutinib1
iGMDRD427ABT7372
iGMDRD1038X3.Cl.AHPC1
iGMDRD399Selumetinib1
iGMDRD641SCH 797971
iGMDRD74Idarubicin4
iGMDRD323Leptomycin B1
iGMDRD188Piperlongumine2
iGMDRD64Parbendazole2
iGMDRD190Nilotinib1
iGMDRD106Clofarabine1
iGMDRD294Batimastat2
iGMDRD117Docetaxel1
iGMDRD284Palbociclib1
iGMDRD171Pemetrexed2
iGMDRD351GW843682X1
iGMDRD750TRIAZOLOTHIADIAZINE1
iGMDRD901ELCPK2
iGMDRD798Ceranib-21
iGMDRD250IPR-4561
iGMDRD256NVP-2311
iGMDRD456Crizotinib1
iGMDRD141NSC483001
iGMDRD646PHA-7938871
iGMDRD353PD03259012
iGMDRD505Pevonedistat1
iGMDRD300Tozasertib4
iGMDRD479Veliparib1
iGMDRD208Necrosulfonamide1
iGMDRD271Brefeldin A1
iGMDRD504Obatoclax1
iGMDRD68Paclitaxel1
iGMDRD78Topotecan1
iGMDRD193Fqi11
iGMDRD634SCHEMBL26080412
iGMDRD348BMS-3455411
iGMDRD1008SR-II-138A1
iGMDRD313Axitinib1
iGMDRD136Nutlin-31
iGMDRD562Navitoclax2
iGMDRD577BIX012941
iGMDRD609BRD-K664538931
iGMDRD145Omacetaxine mepesuccinate1
iGMDRD60Quinoclamine4
iGMDRD255SB2250021
iGMDRD491TAE-6841
iGMDRD318PAC-13
iGMDRD573GSK-1904529A1
iGMDRD219Bax channel blocker3
iGMDRD352PD-03259011
iGMDRD540Alisertib1
iGMDRD154NSC237663
iGMDRD123Isoevodiamine4
iGMDRD942MEDI47361
iGMDRD79Gemcitabine1
iGMDRD681SB-7439211
iGMDRD445Barasertib1
iGMDRD87Epigallocatechin-3-monogallate1
iGMDRD871BRD63681
iGMDRD664Dinaciclib1
iGMDRD552AZD-17751
iGMDRD439KW-24491
iGMDRD158NSC1415404
iGMDRD137Indisulam3
iGMDRD121GMX17783
iGMDRD103SN-381
iGMDRD244ML3111
iGMDRD61Kinetin riboside3
iGMDRD890CR.1.31B1
iGMDRD639YK 4-2791
iGMDRD358Semagacestat1
iGMDRD273Alvocidib1
iGMDRD433Lexibulin2
iGMDRD397Pazopanib1
iGMDRD670ML 2102
iGMDRD546BMS-7548071
iGMDRD888Compound 442
iGMDRD730Kahalalide F3
iGMDRD602Foretinib1
iGMDRD23Gossypol2
iGMDRD260FQI-24
iGMDRD848BRD-K284567061
iGMDRD187BRD98761
iGMDRD941MEDI06801
iGMDRD536PLX-47201
iGMDRD85Ursolic acid1
iGMDRD843BRD-A867083391
iGMDRD435BI-25361
iGMDRD512nutlin 33
iGMDRD84Lovastatin acid2
iGMDRD125BIRB-7961
iGMDRD116CD4371
iGMDRD477AT133871
iGMDRD246NPC262
iGMDRD886Compound 1541A2
iGMDRD157Ouabain1
iGMDRD434BMS-5369245
iGMDRD528rigosertib1
iGMDRD446LY 21832408
iGMDRD591PF-37583091
iGMDRD280CYTOCHALASIN B3
iGMDRD857BRD-K705115741
iGMDRD599Salermide3
iGMDRD708BRD-K634312401
iGMDRD489GSK-4613641
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD887Compound 23 citrate2
iGMDRD100Zebularine7
iGMDRD451Serdemetan1
iGMDRD444Tivantinib1
iGMDRD640CAY106181
iGMDRD533HSCI1_0002701
iGMDRD270Ciclosporin2
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MSH6

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