iGMDRD250


Canonical SMILES: CC1CC(CN(C1)C2=CC(=C3C4=C(C5=CC=CC=C5C3=O)ON=C24)NC6=CC=CC=C6C(=O)O)C

InChI: InChI=1S/C28H25N3O4/c1-15-11-16(2)14-31(13-15)22-12-21(29-20-10-6-5-9-19(20)28(33)34)23-24-25(22)30-35-27(24)18-8-4-3-7-17(18)26(23)32/h3-10,12,15-16,29H,11,13-14H2,1-2H3,(H,33,34)

InChI Key: HQQHYDSAYJUPSU-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameIPR-456
Pubchem CID3676140
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Drug-gene pathway enrichments

1wikipathways: Chromosomal and microsatellite instability in colorectal cancer1wikipathways: Retinoblastoma (RB) in Cancer1wikipathways: Mismatch repair1kegg: Mismatch repair - Homo sapiens (human)1kegg: Colorectal cancer - Homo sapiens (human)1kegg: Pathways in cancer - Homo sapiens (human)1wikipathways: Signaling Pathways in Glioblastoma1reactome: DNA Repair1reactome: Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)1reactome: Mismatch Repair

Drug-gene GO enrichments

5BP: mismatch repair3MF: mismatched DNA binding2BP: positive regulation of isotype switching2BP: negative regulation of DNA recombination2BP: meiotic mismatch repair2BP: positive regulation of helicase activity2MF: ADP binding2BP: isotype switching2BP: maintenance of DNA repeat elements2BP: somatic hypermutation of immunoglobulin genes

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2956 MSH6 1
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Gene in drug-gene network: Network Plot

Models in IPR-456

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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