iGMDRD681


Canonical SMILES: CC1=CC=C(C=C1)C(=O)N(CCCN)C(C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl

InChI: InChI=1S/C31H33ClN2O3.ClH/c1-20(2)28(34(17-7-16-33)31(36)23-12-10-21(3)11-13-23)30-26(18-22-8-5-4-6-9-22)29(35)25-15-14-24(32)19-27(25)37-30;/h4-6,8-15,19-20,28H,7,16-18,33H2,1-3H3;1H/t28-;/m1./s1

InChI Key: MLMZVWABFOLFGV-LNLSOMNWSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameSB-743921
Pubchem CID49867900
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 2LIVEtissue: LIVE cancer: LIVER model num: 0LIVERtissue: LIVER cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 19

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
7514 XPO1 1
2956 MSH6 1
64783 RBM15 1
6598 SMARCB1 1
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Gene in drug-gene network: Network Plot

SMAD1SMAD1CAY10618CAY10618tivozanibtivozanibHSCI1_000270HSCI1_000270docetaxel in KRAS mutantdocetaxel in KRAS mutantNVP-231NVP-231daporinaddaporinadCD437CD437DPP4DPP4selumetinib in BRAF mutant tumorsselumetinib in BRAF mutant tumorspyrvinium pamoatepyrvinium pamoatetipifarnib-P2tipifarnib-P2OSI-906 (Linsitinib)OSI-906 (Linsitinib)BMS-536924BMS-536924BIX01294BIX01294CHIR-99021CHIR-99021PNU-74654PNU-74654isoevodiamineisoevodiamineGW-843682XGW-843682XCompound.7d.cisCompound.7d.cisABT737ABT737Merck60Merck60PK-11195PK-11195fumonisin.B1fumonisin.B1LY 2183240LY 2183240Tyrphostin AG 1478Tyrphostin AG 1478zebularinezebularineSirolimusSirolimusMCL1MCL1BMS-754807BMS-754807MST-312MST-312PX 12PX 12NeratinibNeratinibcytochalasin.Bcytochalasin.BPIK-75PIK-75AZD-1775AZD-1775ML162ML162ceruleninceruleninFedratinibFedratinibAACOCF3AACOCF3(-)-gallocatechin-3-O-gallate(-)-gallocatechin-3-O-gallateKDRKDRBI-2536BI-2536PaclitaxelPaclitaxelGSK-461364GSK-461364XL-880XL-880PF 184PF 184XPO1XPO1IdarubicinIdarubicinquinoclaminequinoclaminenakiterpiosinnakiterpiosinNSC141540NSC141540VX-680VX-680Nsc 632839Nsc 632839FQI-2FQI-2MSH6MSH6ELCPKELCPKimportazoleimportazoleGMX1778GMX1778tamatinibtamatinibchaetocinchaetocinBRD9876BRD9876NSC23766NSC23766BRD7137BRD7137PF750PF7504-methylfasudil4-methylfasudilACVRL1ACVRL1GW-405833GW-405833serdemetanserdemetanCompound.1541ACompound.1541AEZH2 inhibitorEZH2 inhibitorNVP-AUY922NVP-AUY922piperlonguminepiperlonguminetriptolidetriptolideSMARCB1SMARCB1PD-0325901PD-0325901PYGBPYGBparbendazoleparbendazoleSepantroniumSepantroniumoligomycin.Aoligomycin.A179324-69-7179324-69-7ChloropentafluorobenzeneChloropentafluorobenzeneCHM-1CHM-1RBM15RBM15ISX-9ISX-9BRD6368BRD6368leucascandrolide Aleucascandrolide AavrainvillamideavrainvillamideNPC26NPC26PAC-1PAC-1PDGFRBPDGFRBEpigallocatechin-3-monogallateEpigallocatechin-3-monogallateERVK-19ERVK-19SB-743921SB-743921

Models in SB-743921

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(4EBP1_pS65) protein MCLP LUNG undefined SB.743921 resistance in vitro
EXP(4EBP1_pT37T46) protein MCLP LUNG undefined SB.743921 resistance in vitro
EXP(CAVEOLIN1) protein MCLP LUNG undefined SB.743921 sensitivity in vitro
EXP(TRANSGLUTAMINASE) protein MCLP LUNG undefined SB.743921 sensitivity in vitro
EXP(CMET) protein MCLP LUNG undefined SB.743921 sensitivity in vitro
EXP(CD26) protein MCLP LUNG undefined SB.743921 sensitivity in vitro
EXP(NFKBP65_pS536) protein MCLP BREAST undefined SB.743921 resistance in vitro
EXP(PR) protein MCLP BREAST undefined SB.743921 sensitivity in vitro
EXP(STAT3_pY705) protein MCLP LIVER undefined SB.743921 sensitivity in vitro
EXP(4EBP1_pS65) protein MCLP undefined PANCAN SB.743921 resistance in vitro
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