DPP4
Summary: The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dipeptidyl peptidase 4 | MIM:102720 | Ensembl:ENSG00000197635 | HGNC:HGNC:3009 | PA27467 | 2q24.2 |
GO terms in DPP4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005765 | lysosomal membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0009986 | cell surface |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | IDA | GO:0030027 | lamellipodium |
| CC | IDA | GO:0030139 | endocytic vesicle |
| CC | IEA | GO:0031258 | lamellipodium membrane |
| CC | IEA | GO:0045121 | membrane raft |
| CC | IEA | GO:0046581 | intercellular canaliculus |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0071438 | invadopodium membrane |
| BP | IEA | GO:0001662 | behavioral fear response |
| BP | IDA | GO:0001666 | response to hypoxia |
| BP | IDA | GO:0006508 | proteolysis |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0010716 | negative regulation of extracellular matrix disassembly |
| BP | IDA | GO:0031295 | T cell costimulation |
| BP | IDA | GO:0033632 | regulation of cell-cell adhesion mediated by integrin |
| BP | IEA | GO:0035641 | locomotory exploration behavior |
| BP | IEA | GO:0036343 | psychomotor behavior |
| BP | IDA | GO:0042110 | T cell activation |
| BP | IDA | GO:0043542 | endothelial cell migration |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | TAS | GO:0050796 | regulation of insulin secretion |
| MF | IDA | GO:0001618 | virus receptor activity |
| MF | IPI | GO:0002020 | protease binding |
| MF | EXP | GO:0004252 | serine-type endopeptidase activity |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008236 | serine-type peptidase activity |
| MF | IDA | GO:0008239 | dipeptidyl-peptidase activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: DPP4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DPP4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2980736 | Peptide hormone metabolism |
| reactome | R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400508 | Incretin synthesis, secretion, and inactivation |
| reactome | R-HSA-400511 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| kegg | hsa04974 | Protein digestion and absorption - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD323 | Leptomycin B | 1 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD609 | BRD-K66453893 | 1 |
| iGMDRD533 | HSCI1_000270 | 2 |
| iGMDRD640 | CAY10618 | 2 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD94 | Narciclasine | 1 |
| iGMDRD444 | Tivantinib | 2 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD117 | Docetaxel | 2 |
| iGMDRD573 | GSK-1904529A | 1 |
| iGMDRD106 | Clofarabine | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD528 | rigosertib | 1 |
| iGMDRD793 | BEC (hydrochloride) | 1 |
| iGMDRD78 | Topotecan | 1 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD857 | BRD-K70511574 | 1 |
| iGMDRD489 | GSK-461364 | 1 |
| iGMDRD445 | Barasertib | 1 |
| iGMDRD561 | ABT-263 | 1 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD526 | KX2-391 | 1 |
| iGMDRD103 | SN-38 | 1 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD439 | KW-2449 | 1 |
| iGMDRD787 | PF 184 | 1 |
| iGMDRD479 | Veliparib | 1 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD244 | ML311 | 1 |
| iGMDRD49 | Mitomycin | 1 |
| iGMDRD540 | Alisertib | 1 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD750 | TRIAZOLOTHIADIAZINE | 1 |
| iGMDRD279 | Istradefylline | 1 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD176 | Decitabine | 1 |
| iGMDRD798 | Ceranib-2 | 1 |
| iGMDRD681 | SB-743921 | 2 |
| iGMDRD321 | Daporinad | 2 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD150 | RITA | 1 |
| iGMDRD256 | NVP-231 | 2 |
| iGMDRD79 | Gemcitabine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DPP4
CLASSFICATION
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