iGMDRD323

Canonical SMILES: CCC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C=CC1C(C=CC(=O)O1)C

InChI: InChI=1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1

InChI Key: YACHGFWEQXFSBS-XYERBDPFSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameLeptomycin B
Pubchem CID6917910
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: undefined model num: 1LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 1BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 3LIVEtissue: LIVE cancer: LIVER model num: 0LIVERtissue: LIVER cancer: undefined model num: 2undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 12

Drug-gene pathway enrichments

4reactome: DNA Repair4reactome: Cell Cycle3reactome: RNA Polymerase II Transcription3reactome: Gene expression (Transcription)3reactome: Signal Transduction3reactome: Metabolism of proteins3reactome: Generic Transcription Pathway3reactome: Mismatch Repair2reactome: Cell Cycle Checkpoints2wikipathways: Mismatch repair

Drug-gene GO enrichments

10CC: nucleoplasm8BP: mismatch repair8MF: protein binding6CC: nucleus5CC: nuclear chromosome, telomeric region5CC: cytoplasm4MF: ATP binding4CC: membrane3BP: positive regulation of transcription, DNA-templated3MF: MutLalpha complex binding

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
7514 XPO1 1
2956 MSH6 1
83481 EPPK1 1
2625 GATA3 1
Showing 1 to 4 of 8 rows

Gene in drug-gene network: Network Plot

Models in Leptomycin B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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