MAGI1


Summary: The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
membrane associated guanylate kinase, WW and PDZ domain containing 1MIM:602625Ensembl:ENSG00000151276HGNC:HGNC:946PA1647420063p14.1

GO terms in MAGI1


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0007155cell adhesion
BPTASGO:0007166cell surface receptor signaling pathway
BPNASGO:0065003protein-containing complex assembly
BPIMPGO:0070997neuron death
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIEAGO:0005886plasma membrane
CCTASGO:0005911cell-cell junction
CCISSGO:0005912adherens junction
CCIEAGO:0005923bicellular tight junction
CCIDAGO:0030054cell junction
CCIDAGO:0042995cell projection
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFTASGO:0008022protein C-terminus binding
MFIEAGO:0032947protein-containing complex scaffold activity
MFIPIGO:0051393alpha-actinin binding

Gene expression in normal tissue: MAGI1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAGI1


DatabasePathway IDPathway Des.
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
netpathPathway_EGFR1EGFR1

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD145Omacetaxine mepesuccinate1
iGMDRD562Navitoclax6
iGMDRD19VALPROIC ACID1
iGMDRD577BIX012943
iGMDRD640CAY106181
iGMDRD533HSCI1_0002701
iGMDRD907EZH2 inhibitor3
iGMDRD255SB2250026
iGMDRD573GSK-1904529A1
iGMDRD498GW441756X1
iGMDRD446LY 21832401
iGMDRD78Topotecan1
iGMDRD401Afatinib2
iGMDRD280CYTOCHALASIN B3
iGMDRD776QL-XI-921
iGMDRD634SCHEMBL26080412
iGMDRD112Methotrexate1
iGMDRD144NSC953972
iGMDRD63Camptothecin1
iGMDRD971PARP inhibitor6
iGMDRD587CHEMBL5859511
iGMDRD489GSK-4613641
iGMDRD494Neopeltolide3
iGMDRD872BRD71373
iGMDRD246NPC263
iGMDRD300Tozasertib1
iGMDRD505Pevonedistat1
iGMDRD42Vorinostat2
iGMDRD917HDAC inhibitor3
iGMDRD157Ouabain1
iGMDRD434BMS-5369245
iGMDRD88AICA ribonucleotide1
iGMDRD504Obatoclax1
iGMDRD68Paclitaxel1
iGMDRD435BI-25361
iGMDRD750TRIAZOLOTHIADIAZINE1
iGMDRD426WP11301
iGMDRD153Bardoxolone methyl1
iGMDRD792Cetuximab1
iGMDRD512nutlin 33
iGMDRD116CD4375
iGMDRD256NVP-2311
iGMDRD641SCH 797971
iGMDRD188Piperlongumine3
iGMDRD323Leptomycin B1
iGMDRD780PP-301
iGMDRD94Narciclasine1
iGMDRD429Amuvatinib1
iGMDRD437852475-26-41
iGMDRD649R4281
iGMDRD639YK 4-2791
iGMDRD466Chaetocin3
iGMDRD679Bistramide A4
iGMDRD571Cabozantinib1
iGMDRD126Tipifarnib1
iGMDRD12Bicalutamide1
iGMDRD273Alvocidib1
iGMDRD781Sirolimus6
iGMDRD286Nsc 6328391
iGMDRD871BRD63683
iGMDRD327LBH-5891
iGMDRD161Trichostatin A1
iGMDRD366PI-1035
iGMDRD552AZD-17751
iGMDRD672Alectinib1
iGMDRD362Mocetinostat1
iGMDRD215CCT0070931
iGMDRD352PD-03259011
iGMDRD123Isoevodiamine3
iGMDRD150RITA3
iGMDRD50Cytarabine1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAGI1

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