MAGI1
Summary: The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| membrane associated guanylate kinase, WW and PDZ domain containing 1 | MIM:602625 | Ensembl:ENSG00000151276 | HGNC:HGNC:946 | PA164742006 | 3p14.1 |
GO terms in MAGI1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | NAS | GO:0065003 | protein-containing complex assembly |
| BP | IMP | GO:0070997 | neuron death |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005911 | cell-cell junction |
| CC | ISS | GO:0005912 | adherens junction |
| CC | IEA | GO:0005923 | bicellular tight junction |
| CC | IDA | GO:0030054 | cell junction |
| CC | IDA | GO:0042995 | cell projection |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0008022 | protein C-terminus binding |
| MF | IEA | GO:0032947 | protein-containing complex scaffold activity |
| MF | IPI | GO:0051393 | alpha-actinin binding |
Gene expression in normal tissue: MAGI1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAGI1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD145 | Omacetaxine mepesuccinate | 1 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD19 | VALPROIC ACID | 1 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD640 | CAY10618 | 1 |
| iGMDRD533 | HSCI1_000270 | 1 |
| iGMDRD907 | EZH2 inhibitor | 3 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD573 | GSK-1904529A | 1 |
| iGMDRD498 | GW441756X | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD78 | Topotecan | 1 |
| iGMDRD401 | Afatinib | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD776 | QL-XI-92 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD63 | Camptothecin | 1 |
| iGMDRD971 | PARP inhibitor | 6 |
| iGMDRD587 | CHEMBL585951 | 1 |
| iGMDRD489 | GSK-461364 | 1 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD917 | HDAC inhibitor | 3 |
| iGMDRD157 | Ouabain | 1 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD88 | AICA ribonucleotide | 1 |
| iGMDRD504 | Obatoclax | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD435 | BI-2536 | 1 |
| iGMDRD750 | TRIAZOLOTHIADIAZINE | 1 |
| iGMDRD426 | WP1130 | 1 |
| iGMDRD153 | Bardoxolone methyl | 1 |
| iGMDRD792 | Cetuximab | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD116 | CD437 | 5 |
| iGMDRD256 | NVP-231 | 1 |
| iGMDRD641 | SCH 79797 | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD323 | Leptomycin B | 1 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD94 | Narciclasine | 1 |
| iGMDRD429 | Amuvatinib | 1 |
| iGMDRD437 | 852475-26-4 | 1 |
| iGMDRD649 | R428 | 1 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD679 | Bistramide A | 4 |
| iGMDRD571 | Cabozantinib | 1 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD273 | Alvocidib | 1 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD327 | LBH-589 | 1 |
| iGMDRD161 | Trichostatin A | 1 |
| iGMDRD366 | PI-103 | 5 |
| iGMDRD552 | AZD-1775 | 1 |
| iGMDRD672 | Alectinib | 1 |
| iGMDRD362 | Mocetinostat | 1 |
| iGMDRD215 | CCT007093 | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD50 | Cytarabine | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAGI1
CLASSFICATION
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