iGMDRD489

Canonical SMILES: CC(C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N

InChI: InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1

InChI Key: ZHJGWYRLJUCMRT-QGZVFWFLSA-N

Standard NameCHEMBLPubchem CIDDrug StatusDrug Type
GSK-461364CHEMBL1908394 15984000AloneSmall Molecule

Drug Targets:

PLK1

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
7514XPO12
10987COPS51
2956MSH61
4170MCL11
2625GATA31
5159PDGFRB1
7158TP53BP11
5834PYGB1
4086SMAD11
57111RAB251
3485IGFBP21
1869E2F11
2648KAT2A1
1027CDKN1B1
8821INPP4B1
2067ERCC11
10111RAD501
9223MAGI11
100862685ERVK-191
2065ERBB31
3488IGFBP51
94ACVRL11
1803DPP41

Gene in drug-gene network: Network Plot

Models in GSK-461364

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