iGMDRD489

Canonical SMILES: CC(C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N

InChI: InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1

InChI Key: ZHJGWYRLJUCMRT-QGZVFWFLSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameGSK-461364
CHEMBLCHEMBL1908394
Pubchem CID15984000
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

PLK1

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 4PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: undefined model num: 1BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 10LIVEtissue: LIVE cancer: LIVER model num: 0LIVERtissue: LIVER cancer: undefined model num: 2undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 26

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
7514 XPO1 2
10987 COPS5 1
2956 MSH6 1
4170 MCL1 1
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Gene in drug-gene network: Network Plot

CCT 018159CCT 018159cytarabine.hydrochloridecytarabine.hydrochlorideGW-843682XGW-843682XCamptothecinCamptothecinZM-447439ZM-447439NSC141540NSC141540Liposomal DoxorubicinLiposomal DoxorubicinVX-680VX-680Epothilone.BEpothilone.BAZD7762AZD7762VincaleukoblastineVincaleukoblastineKAT2AKAT2API-103PI-103BMS-536924BMS-536924navitoclaxnavitoclaxSB225002SB225002bistramide Abistramide APARP inhibitorsPARP inhibitorsSirolimusSirolimusCD437CD437MAGI1MAGI1SN-38SN-38BMS-754807BMS-754807isoevodiamineisoevodiamineSR-II-138ASR-II-138AcurcumincurcuminE2F1E2F1AfatnibAfatnibRAB25RAB25PD184352PD184352semagacestatsemagacestatCis-PlatinCis-PlatinERCC1ERCC1PD-0325901PD-0325901PYGBPYGBselumetinib in BRAF mutant tumorsselumetinib in BRAF mutant tumorspyrvinium pamoatepyrvinium pamoatetipifarnib-P2tipifarnib-P2OSI-906 (Linsitinib)OSI-906 (Linsitinib)BIX01294BIX01294CHIR-99021CHIR-99021PNU-74654PNU-74654Compound.7d.cisCompound.7d.cisABT737ABT737Merck60Merck60PK-11195PK-11195fumonisin.B1fumonisin.B1LY 2183240LY 2183240Tyrphostin AG 1478Tyrphostin AG 1478zebularinezebularineMCL1MCL1kinetin ribosidekinetin ribosideMST-312MST-312NSC95397NSC95397austocystin.Daustocystin.DNsc 632839Nsc 632839piperlonguminepiperlongumineCOPS5COPS5ELCPKELCPKcytochalasin.Bcytochalasin.BPIK-75PIK-75BRD6368BRD6368tanespimycintanespimycinML214ML214PI3K pathway inhibitorsPI3K pathway inhibitorsindisulamindisulam4-methylfasudil4-methylfasudilINPP4BINPP4BCAY10618CAY10618tivozanibtivozanibHSCI1_000270HSCI1_000270docetaxel in KRAS mutantdocetaxel in KRAS mutantNVP-231NVP-231SB-743921SB-743921daporinaddaporinadDPP4DPP4SMAD1SMAD1IdarubicinIdarubicinbrefeldin.Abrefeldin.AABT-751ABT-751nakiterpiosinnakiterpiosinNSC23766NSC23766triptolidetriptolideteniposideteniposideIGFBP5IGFBP5BI-2536BI-2536AZD-1775AZD-1775PaclitaxelPaclitaxelXL-880XL-880PF 184PF 184XPO1XPO1Compound 10b [PMID: 11504634]Compound 10b [PMID: 11504634]ChloropentafluorobenzeneChloropentafluorobenzeneFQI-2FQI-2CHM-1CHM-1RAD50RAD50quinoclaminequinoclamineMSH6MSH6importazoleimportazoleFedratinibFedratinibGMX1778GMX1778tamatinibtamatinibchaetocinchaetocinBRD9876BRD9876BRD7137BRD7137PF750PF750ACVRL1ACVRL1ISX-9ISX-9leucascandrolide Aleucascandrolide AavrainvillamideavrainvillamideNPC26NPC26PAC-1PAC-1PDGFRBPDGFRBAromatase InhibitorAromatase InhibitorGATA3GATA3Epigallocatechin-3-monogallateEpigallocatechin-3-monogallateERVK-19ERVK-19RITARITAVER 155008VER 155008SepantroniumSepantroniumSMR000068650SMR000068650TP53BP1TP53BP1MEK inhibitorsMEK inhibitorsPertuzumabPertuzumablapatinib in HER2-amplifiedlapatinib in HER2-amplified(-)-gallocatechin-3-O-gallate(-)-gallocatechin-3-O-gallateoligomycin.Aoligomycin.ApevonedistatpevonedistatERBB3ERBB3CDK2/4 inhibitorsCDK2/4 inhibitorsVNLG/124VNLG/124SCHEMBL2608041SCHEMBL2608041CDKN1BCDKN1BtacedinalinetacedinalineBX-795BX-795VeliparibVeliparibLE-135LE-135DasatnibDasatnibAT-406AT-406CCT007093CCT007093STF-31STF-31NSC74859NSC74859necrosulfonamidenecrosulfonamideDMOGDMOGIGFBP2IGFBP2GSK-461364GSK-461364

Models in GSK-461364

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(BETACATENIN) protein MCLP LUNG undefined GSK461364 sensitivity in vitro
EXP(CLAUDIN7) protein MCLP LUNG undefined GSK461364 sensitivity in vitro
EXP(ECADHERIN) protein MCLP LUNG undefined GSK461364 sensitivity in vitro
EXP(INPP4B) protein MCLP LUNG undefined GSK461364 sensitivity in vitro
EXP(E2F1) protein MCLP PANCREAS undefined GSK461364 sensitivity in vitro
EXP(ERALPHA) protein MCLP BREAST undefined GSK461364 sensitivity in vitro
EXP(GATA3) protein MCLP BREAST undefined GSK461364 sensitivity in vitro
EXP(IGFBP2) protein MCLP BREAST undefined GSK461364 sensitivity in vitro
EXP(NFKBP65_pS536) protein MCLP BREAST undefined GSK461364 resistance in vitro
EXP(PKCALPHA) protein MCLP BREAST undefined GSK461364 resistance in vitro
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