RAB25


Summary: The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RAB25, member RAS oncogene familyMIM:612942Ensembl:ENSG00000132698HGNC:HGNC:18238PA341151q22

GO terms in RAB25


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0003924GTPase activity
MFIEAGO:0003924GTPase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005525GTP binding
MFIPIGO:0031489myosin V binding
BPISSGO:0003382epithelial cell morphogenesis
BPIBAGO:0006886intracellular protein transport
BPIBAGO:0006887exocytosis
BPIDAGO:0008284positive regulation of cell proliferation
BPIMPGO:0010634positive regulation of epithelial cell migration
BPIEAGO:0015031protein transport
BPIDAGO:0031268pseudopodium organization
BPIBAGO:0032482Rab protein signal transduction
BPIMPGO:0060627regulation of vesicle-mediated transport
CCIBAGO:0005768endosome
CCIBAGO:0012505endomembrane system
CCIDAGO:0031143pseudopodium
CCIEAGO:0031260pseudopodium membrane
CCIDAGO:0031410cytoplasmic vesicle
CCIBAGO:0055037recycling endosome
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: RAB25

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAB25


DatabasePathway IDPathway Des.
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8873719RAB geranylgeranylation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD170Fluvastatin1
iGMDRD536PLX-47201
iGMDRD633AVICIN D1
iGMDRD873BRD88991
iGMDRD426WP11301
iGMDRD154NSC237661
iGMDRD883CIL55A1
iGMDRD382CEP-7011
iGMDRD262KU-559331
iGMDRD798Ceranib-21
iGMDRD614Dabrafenib1
iGMDRD160Cis-Platin1
iGMDRD594AZD-80551
iGMDRD50Cytarabine1
iGMDRD119Temsirolimus1
iGMDRD414MST-3121
iGMDRD713BRD-K024921471
iGMDRD3PD-1730741
iGMDRD505Pevonedistat1
iGMDRD421AZD77621
iGMDRD42Vorinostat1
iGMDRD124Canertinib1
iGMDRD714BRD-K170607501
iGMDRD202Curcumin1
iGMDRD251ML1621
iGMDRD402AKT Inhibitor VIII1
iGMDRD481Dactolisib1
iGMDRD551Ponatinib1
iGMDRD446LY 21832401
iGMDRD253Vincaleukoblastine1
iGMDRD259EX-5271
iGMDRD297Austocystin D1
iGMDRD673LSM-12151
iGMDRD394BX-7951
iGMDRD401Afatinib2
iGMDRD76Simvastatin1
iGMDRD313Axitinib1
iGMDRD409Saracatinib1
iGMDRD63Camptothecin1
iGMDRD549Ibrutinib (PCI-32765)1
iGMDRD1Nicotin-Amide1
iGMDRD670ML 2101
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD489GSK-4613641
iGMDRD397Pazopanib1
iGMDRD75Lovastatin1
iGMDRD133Lapatinib1
iGMDRD887Compound 23 citrate1
iGMDRD185DMOG1
iGMDRD146Elesclomol1
iGMDRD431NU-74411
iGMDRD131Erlotinib1
iGMDRD640CAY106181
iGMDRD190Nilotinib1
iGMDRD109Gefitinib1
iGMDRD203STF-311
iGMDRD647StemRegenin 11
iGMDRD441TW 371
iGMDRD318PAC-11
iGMDRD1037X1S.3R.RSL.31

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAB25

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