RAB25
Summary: The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RAB25, member RAS oncogene family | MIM:612942 | Ensembl:ENSG00000132698 | HGNC:HGNC:18238 | PA34115 | 1q22 |
GO terms in RAB25
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003924 | GTPase activity |
| MF | IEA | GO:0003924 | GTPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | IPI | GO:0031489 | myosin V binding |
| BP | ISS | GO:0003382 | epithelial cell morphogenesis |
| BP | IBA | GO:0006886 | intracellular protein transport |
| BP | IBA | GO:0006887 | exocytosis |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0010634 | positive regulation of epithelial cell migration |
| BP | IEA | GO:0015031 | protein transport |
| BP | IDA | GO:0031268 | pseudopodium organization |
| BP | IBA | GO:0032482 | Rab protein signal transduction |
| BP | IMP | GO:0060627 | regulation of vesicle-mediated transport |
| CC | IBA | GO:0005768 | endosome |
| CC | IBA | GO:0012505 | endomembrane system |
| CC | IDA | GO:0031143 | pseudopodium |
| CC | IEA | GO:0031260 | pseudopodium membrane |
| CC | IDA | GO:0031410 | cytoplasmic vesicle |
| CC | IBA | GO:0055037 | recycling endosome |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: RAB25
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RAB25
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8873719 | RAB geranylgeranylation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD170 | Fluvastatin | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD633 | AVICIN D | 1 |
| iGMDRD873 | BRD8899 | 1 |
| iGMDRD426 | WP1130 | 1 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD262 | KU-55933 | 1 |
| iGMDRD798 | Ceranib-2 | 1 |
| iGMDRD614 | Dabrafenib | 1 |
| iGMDRD160 | Cis-Platin | 1 |
| iGMDRD594 | AZD-8055 | 1 |
| iGMDRD50 | Cytarabine | 1 |
| iGMDRD119 | Temsirolimus | 1 |
| iGMDRD414 | MST-312 | 1 |
| iGMDRD713 | BRD-K02492147 | 1 |
| iGMDRD3 | PD-173074 | 1 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD124 | Canertinib | 1 |
| iGMDRD714 | BRD-K17060750 | 1 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD251 | ML162 | 1 |
| iGMDRD402 | AKT Inhibitor VIII | 1 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD551 | Ponatinib | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD253 | Vincaleukoblastine | 1 |
| iGMDRD259 | EX-527 | 1 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD673 | LSM-1215 | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD401 | Afatinib | 2 |
| iGMDRD76 | Simvastatin | 1 |
| iGMDRD313 | Axitinib | 1 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD63 | Camptothecin | 1 |
| iGMDRD549 | Ibrutinib (PCI-32765) | 1 |
| iGMDRD1 | Nicotin-Amide | 1 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD489 | GSK-461364 | 1 |
| iGMDRD397 | Pazopanib | 1 |
| iGMDRD75 | Lovastatin | 1 |
| iGMDRD133 | Lapatinib | 1 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD185 | DMOG | 1 |
| iGMDRD146 | Elesclomol | 1 |
| iGMDRD431 | NU-7441 | 1 |
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD640 | CAY10618 | 1 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD109 | Gefitinib | 1 |
| iGMDRD203 | STF-31 | 1 |
| iGMDRD647 | StemRegenin 1 | 1 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD1037 | X1S.3R.RSL.3 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RAB25
CLASSFICATION
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