RAB25

Summary: The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameRAB25, member RAS oncogene family
OMIM IDMIM:612942
Ensembl IDEnsembl:ENSG00000132698
HGNC IDHGNC:HGNC:18238
PHARMGKB IDPA34115
Map Location1q22

GO terms in RAB25


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0003924 GTPase activity
MF IEA GO:0003924 GTPase activity
MF IPI GO:0005515 protein binding
MF IEA GO:0005525 GTP binding
MF IPI GO:0031489 myosin V binding
BP ISS GO:0003382 epithelial cell morphogenesis
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Gene expression in normal tissue: RAB25

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: undefined model num: 2undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 55OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 4

Gene-drug pathway distribution

undefined24RTK signaling5PI3K/MTOR signaling4EGFR signaling3Terpenoid backbone biosynthesis2Chromatin histone acetylation2ERK MAPK signaling2Apoptosis regulation2Other, kinases2DNA replication2

Pathways in RAB25


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Database
Pathway ID
Pathway Des.
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-597592 Post-translational protein modification
reactome R-HSA-8873719 RAB geranylgeranylation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD170 Fluvastatin 1
iGMDRD536 PLX-4720 1
iGMDRD633 AVICIN D 1
iGMDRD873 BRD8899 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAB25

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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