iGMDRD3

Canonical SMILES: CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C

InChI: InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36)

InChI Key: DXCUKNQANPLTEJ-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NamePD-173074
CHEMBLCHEMBL189584
Pubchem CID1401
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

FGFR1FGFR3

Drug Pathways:

RTK signaling

Drug-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 1OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 11UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: undefined model num: 1UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 1LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 1HEAD_NECtissue: HEAD_NEC cancer: HEAD_NECK model num: 0HEAD_NECKtissue: HEAD_NECK cancer: Head and Neck Squamous Cell Carcinoma (HNSC) model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1BLADDEtissue: BLADDE cancer: BLADDER model num: 0BLADDERtissue: BLADDER cancer: Bladder Cancer model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Squamous Cell Carcinoma (LUSC) model num: 1LUNGtissue: LUNG cancer: Non-Small Cell Lung Cancer (NSCLC) model num: 1BILIARY_TRACtissue: BILIARY_TRAC cancer: BILIARY_TRACT model num: 0BILIARY_TRACTtissue: BILIARY_TRACT cancer: Cholangiocarcinoma (CHOL) model num: 2

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3845 KRAS 1
57580 PREX1 1
6598 SMARCB1 1
9757 KMT2B 1
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Gene in drug-gene network: Network Plot

Models in PD-173074

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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