RUNX1
Summary: Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:151385 Ensembl IDEnsembl:ENSG00000159216 HGNC IDHGNC:HGNC:10471 PHARMGKB IDPA34884 Map Location21q22.12 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in RUNX1
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IBA | GO:0005634 | nucleus |
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005654 | nucleoplasm |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0016513 | core-binding factor complex |
Gene expression in normal tissue: RUNX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RUNX1
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-157118 | Signaling by NOTCH |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
reactome | R-HSA-212436 | Generic Transcription Pathway |
reactome | R-HSA-212436 | Generic Transcription Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in RUNX1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |