RUNX1


Summary: Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in RUNX1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005634 nucleus
CC IDA GO:0005634 nucleus
CC IDA GO:0005654 nucleoplasm
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0005829 cytosol
CC TAS GO:0016513 core-binding factor complex
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Gene expression in normal tissue: RUNX1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 37BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: Acute Myeloid Leukemia (AML) model num: 1

Gene-drug pathway distribution

undefined13ERK MAPK signaling3Cell cycle2ABL signaling1Apoptosis regulation1Protein stability and degradation1DNA replication1Mitosis1Purine metabolism1RTK signaling1

Pathways in RUNX1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-157118 Signaling by NOTCH
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-1912408 Pre-NOTCH Transcription and Translation
reactome R-HSA-1912422 Pre-NOTCH Expression and Processing
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-212436 Generic Transcription Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD352 PD-0325901 1
iGMDRD536 PLX-4720 1
iGMDRD57 Chloropentafluorobenzene 1
iGMDRD61 Kinetin riboside 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RUNX1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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