FGFR1
Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fibroblast growth factor receptor 1 | MIM:136350 | Ensembl:ENSG00000077782 | HGNC:HGNC:3688 | PA28127 | 8p11.23 |
GO terms in FGFR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IBA | GO:0005007 | fibroblast growth factor-activated receptor activity |
| MF | IDA | GO:0005007 | fibroblast growth factor-activated receptor activity |
| MF | TAS | GO:0005007 | fibroblast growth factor-activated receptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0008201 | heparin binding |
| MF | TAS | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | IBA | GO:0017134 | fibroblast growth factor binding |
| MF | IDA | GO:0017134 | fibroblast growth factor binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | IDA | GO:0090722 | receptor-receptor interaction |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0001501 | skeletal system development |
| BP | IBA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001657 | ureteric bud development |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0001759 | organ induction |
| BP | TAS | GO:0001764 | neuron migration |
| BP | IEA | GO:0002053 | positive regulation of mesenchymal cell proliferation |
| BP | IEA | GO:0002062 | chondrocyte differentiation |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | NAS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0007417 | central nervous system development |
| BP | IEA | GO:0007605 | sensory perception of sound |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IGI | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IGI | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IPI | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | TAS | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | TAS | GO:0010518 | positive regulation of phospholipase activity |
| BP | IDA | GO:0010863 | positive regulation of phospholipase C activity |
| BP | IEA | GO:0010966 | regulation of phosphate transport |
| BP | IEA | GO:0010976 | positive regulation of neuron projection development |
| BP | TAS | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | TAS | GO:0016477 | cell migration |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0021847 | ventricular zone neuroblast division |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030326 | embryonic limb morphogenesis |
| BP | IEA | GO:0030901 | midbrain development |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IEA | GO:0035607 | fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | IEA | GO:0042472 | inner ear morphogenesis |
| BP | IEA | GO:0042473 | outer ear morphogenesis |
| BP | IEA | GO:0042474 | middle ear morphogenesis |
| BP | TAS | GO:0043009 | chordate embryonic development |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:0043410 | positive regulation of MAPK cascade |
| BP | IGI | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | TAS | GO:0045595 | regulation of cell differentiation |
| BP | IMP | GO:0045666 | positive regulation of neuron differentiation |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | TAS | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | IEA | GO:0048339 | paraxial mesoderm development |
| BP | IEA | GO:0048378 | regulation of lateral mesodermal cell fate specification |
| BP | IEA | GO:0048469 | cell maturation |
| BP | TAS | GO:0048705 | skeletal system morphogenesis |
| BP | IEA | GO:0048762 | mesenchymal cell differentiation |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| BP | IEA | GO:0060117 | auditory receptor cell development |
| BP | IEA | GO:0060445 | branching involved in salivary gland morphogenesis |
| BP | IEA | GO:0060484 | lung-associated mesenchyme development |
| BP | IEA | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0070640 | vitamin D3 metabolic process |
| BP | IEA | GO:0090080 | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway |
| BP | IEA | GO:0090272 | negative regulation of fibroblast growth factor production |
| BP | IEA | GO:1903465 | positive regulation of mitotic cell cycle DNA replication |
| BP | IGI | GO:1905564 | positive regulation of vascular endothelial cell proliferation |
| BP | IDA | GO:2000546 | positive regulation of endothelial cell chemotaxis to fibroblast growth factor |
| BP | IEA | GO:2000830 | positive regulation of parathyroid hormone secretion |
| BP | IEA | GO:2001239 | regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| CC | NAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0043235 | receptor complex |
Gene expression in normal tissue: FGFR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FGFR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1839120 | Signaling by FGFR1 amplification mutants |
| reactome | R-HSA-1839122 | Signaling by activated point mutants of FGFR1 |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-190242 | FGFR1 ligand binding and activation |
| reactome | R-HSA-190370 | FGFR1b ligand binding and activation |
| reactome | R-HSA-190373 | FGFR1c ligand binding and activation |
| reactome | R-HSA-190374 | FGFR1c and Klotho ligand binding and activation |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-445144 | Signal transduction by L1 |
| reactome | R-HSA-5654219 | Phospholipase C-mediated cascade: FGFR1 |
| reactome | R-HSA-5654687 | Downstream signaling of activated FGFR1 |
| reactome | R-HSA-5654688 | SHC-mediated cascade:FGFR1 |
| reactome | R-HSA-5654689 | PI-3K cascade:FGFR1 |
| reactome | R-HSA-5654693 | FRS-mediated FGFR1 signaling |
| reactome | R-HSA-5654726 | Negative regulation of FGFR1 signaling |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2804 | Hair Follicle Development- Induction (Part 1 of 3) |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3995 | Prion disease pathway |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP474 | Endochondral Ossification |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | fgf_pathway | FGF signaling pathway |
| pid | glypican_1pathway | Glypican 1 network |
| pid | ncadherinpathway | N-cadherin signaling events |
| pid | syndecan_1_pathway | Syndecan-1-mediated signaling events |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | syndecan_3_pathway | Syndecan-3-mediated signaling events |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
| pharmgkb | PA165959425 | Pathway_PA165959425 |
| pharmgkb | PA165959584 | Sorafenib Pharmacodynamics |
| pharmgkb | PA165980050 | Vemurafenib Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | update your name in edit mode |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD103 | SN-38 | 6 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD674 | Dovitinib | 2 |
| iGMDRD105 | Triptolide | 6 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD691 | Infigratinib | 4 |
| iGMDRD551 | Ponatinib | 4 |
| iGMDRD286 | Nsc 632839 | 9 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD3 | PD-173074 | 4 |
| iGMDRD246 | NPC26 | 6 |
| iGMDRD263 | AACOCF3 | 6 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD150 | RITA | 1 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD567 | E-3810 | 1 |
| iGMDRD237 | ABT-751 | 6 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD175 | 4-Hydroxytamoxifen | 1 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD885 | Compound 110 | 6 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD911 | FGFR inhibitor | 7 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD685 | AZD4547 | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD359 | OSW-1 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FGFR1
CLASSFICATION
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