SYK
Summary: This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| spleen associated tyrosine kinase | MIM:600085 | Ensembl:ENSG00000165025 | HGNC:HGNC:11491 | PA36273 | 9q22.2 |
GO terms in SYK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IC | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0019815 | B cell receptor complex |
| CC | ISS | GO:0032009 | early phagosome |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0042101 | T cell receptor complex |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | ISS | GO:0001945 | lymph vessel development |
| BP | IEA | GO:0002092 | positive regulation of receptor internalization |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | IBA | GO:0002250 | adaptive immune response |
| BP | ISS | GO:0002250 | adaptive immune response |
| BP | IBA | GO:0002281 | macrophage activation involved in immune response |
| BP | ISS | GO:0002281 | macrophage activation involved in immune response |
| BP | IBA | GO:0002283 | neutrophil activation involved in immune response |
| BP | ISS | GO:0002283 | neutrophil activation involved in immune response |
| BP | ISS | GO:0002366 | leukocyte activation involved in immune response |
| BP | ISS | GO:0002554 | serotonin secretion by platelet |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006606 | protein import into nucleus |
| BP | IDA | GO:0007159 | leukocyte cell-cell adhesion |
| BP | ISS | GO:0007229 | integrin-mediated signaling pathway |
| BP | NAS | GO:0007229 | integrin-mediated signaling pathway |
| BP | IEA | GO:0007257 | activation of JUN kinase activity |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | TAS | GO:0009887 | animal organ morphogenesis |
| BP | ISS | GO:0010543 | regulation of platelet activation |
| BP | IMP | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IEA | GO:0019370 | leukotriene biosynthetic process |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IDA | GO:0030593 | neutrophil chemotaxis |
| BP | ISS | GO:0031623 | receptor internalization |
| BP | IEA | GO:0032481 | positive regulation of type I interferon production |
| BP | ISS | GO:0032753 | positive regulation of interleukin-4 production |
| BP | ISS | GO:0032928 | regulation of superoxide anion generation |
| BP | IBA | GO:0033630 | positive regulation of cell adhesion mediated by integrin |
| BP | ISS | GO:0033630 | positive regulation of cell adhesion mediated by integrin |
| BP | IEA | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | TAS | GO:0038110 | interleukin-2-mediated signaling pathway |
| BP | ISS | GO:0038156 | interleukin-3-mediated signaling pathway |
| BP | ISS | GO:0042742 | defense response to bacterium |
| BP | IBA | GO:0043306 | positive regulation of mast cell degranulation |
| BP | ISS | GO:0043313 | regulation of neutrophil degranulation |
| BP | IEA | GO:0043366 | beta selection |
| BP | ISS | GO:0045087 | innate immune response |
| BP | IEA | GO:0045401 | positive regulation of interleukin-3 biosynthetic process |
| BP | IEA | GO:0045425 | positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process |
| BP | IBA | GO:0045579 | positive regulation of B cell differentiation |
| BP | IMP | GO:0045579 | positive regulation of B cell differentiation |
| BP | IEA | GO:0045588 | positive regulation of gamma-delta T cell differentiation |
| BP | ISS | GO:0045780 | positive regulation of bone resorption |
| BP | IEA | GO:0046638 | positive regulation of alpha-beta T cell differentiation |
| BP | IBA | GO:0046641 | positive regulation of alpha-beta T cell proliferation |
| BP | ISS | GO:0048514 | blood vessel morphogenesis |
| BP | IEA | GO:0050715 | positive regulation of cytokine secretion |
| BP | ISS | GO:0050764 | regulation of phagocytosis |
| BP | IEA | GO:0050850 | positive regulation of calcium-mediated signaling |
| BP | IBA | GO:0050853 | B cell receptor signaling pathway |
| BP | ISS | GO:0050853 | B cell receptor signaling pathway |
| BP | IMP | GO:0051090 | regulation of DNA-binding transcription factor activity |
| BP | ISS | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| BP | ISS | GO:0071226 | cellular response to molecule of fungal origin |
| BP | ISS | GO:0071404 | cellular response to low-density lipoprotein particle stimulus |
| BP | ISS | GO:0090237 | regulation of arachidonic acid secretion |
| BP | IBA | GO:0090330 | regulation of platelet aggregation |
| BP | ISS | GO:0090330 | regulation of platelet aggregation |
| BP | IEA | GO:1900086 | positive regulation of peptidyl-tyrosine autophosphorylation |
| MF | IMP | GO:0001784 | phosphotyrosine residue binding |
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | NAS | GO:0004672 | protein kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | NAS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | TAS | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IPI | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0019902 | phosphatase binding |
| MF | IEA | GO:0035325 | Toll-like receptor binding |
| MF | IEA | GO:0042169 | SH2 domain binding |
Gene expression in normal tissue: SYK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SYK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| biocarta | il2pathway | il 2 signaling pathway |
| biocarta | nkcellspathway | ras-independent pathway in nk cell-mediated cytotoxicity |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029481 | FCGR activation |
| reactome | R-HSA-2029481 | FCGR activation |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-2029485 | Role of phospholipids in phagocytosis |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-2424491 | DAP12 signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization |
| reactome | R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-354192 | Integrin alphaIIb beta3 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621480 | Dectin-2 family |
| reactome | R-HSA-5621480 | Dectin-2 family |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76009 | Platelet Aggregation (Plug Formation) |
| reactome | R-HSA-9006921 | Integrin signaling |
| reactome | R-HSA-9020558 | Interleukin-2 signaling |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP3937 | Microglia Pathogen Phagocytosis Pathway |
| wikipathways | WP4136 | Fibrin Complement Receptor 3 Signaling Pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TNFalpha | TNFalpha |
| pid | alphasynuclein_pathway | Alpha-synuclein signaling |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | gmcsf_pathway | GMCSF-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | nfkappabatypicalpathway | Atypical NF-kappaB pathway |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD647 | StemRegenin 1 | 1 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD146 | Elesclomol | 1 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD133 | Lapatinib | 1 |
| iGMDRD397 | Pazopanib | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD1 | Nicotin-Amide | 1 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD668 | GSK 525762A | 1 |
| iGMDRD687 | I-BET151 | 1 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD259 | EX-527 | 1 |
| iGMDRD363 | OSI-930 | 1 |
| iGMDRD21 | Fluorouracil | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD305 | SYK inhibitor | 8 |
| iGMDRD467 | Motesanib | 1 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD251 | ML162 | 1 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD662 | JQ-1 | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD119 | Temsirolimus | 1 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD15 | Tacedinaline | 1 |
| iGMDRD1036 | X17AAG | 1 |
| iGMDRD50 | Cytarabine | 1 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD698 | Neratinib | 1 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD573 | GSK-1904529A | 1 |
| iGMDRD33 | Entinostat | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD454 | JNK Inhibitor VIII | 1 |
| iGMDRD371 | THR1 Inhibitor | 1 |
| iGMDRD60 | Quinoclamine | 8 |
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD354 | Midostaurin | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD97 | Bexarotene | 1 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD401 | Afatinib | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD253 | Vincaleukoblastine | 1 |
| iGMDRD519 | GDC-0941 | 1 |
| iGMDRD459 | RO-3306 | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD434 | BMS-536924 | 7 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD550 | CGP-082996 | 1 |
| iGMDRD124 | Canertinib | 1 |
| iGMDRD946 | ML320 | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD472 | PF-562271 | 1 |
| iGMDRD3 | PD-173074 | 1 |
| iGMDRD160 | Cis-Platin | 1 |
| iGMDRD657 | LRRK2-IN-1 | 1 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD125 | BIRB-796 | 1 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD450 | JNJ-26854165 | 1 |
| iGMDRD676 | Birinapant | 1 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD452 | PF-573228 | 1 |
| iGMDRD317 | CCT 018159 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SYK
CLASSFICATION
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