iGMDRD657

Canonical SMILES: CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC

InChI: InChI=1S/C31H38N8O3/c1-35-15-17-38(18-16-35)22-11-13-39(14-12-22)29(40)21-9-10-24(27(19-21)42-4)33-31-32-20-26-28(34-31)36(2)25-8-6-5-7-23(25)30(41)37(26)3/h5-10,19-20,22H,11-18H2,1-4H3,(H,32,33,34)

InChI Key: IWMCPJZTADUIFX-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameLRRK2-IN-1
Pubchem CID46843900
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 5

Drug-gene pathway enrichments

2reactome: FCERI mediated Ca+2 mobilization2reactome: Role of LAT2/NTAL/LAB on calcium mobilization2reactome: Fc epsilon receptor (FCERI) signaling2reactome: FCGR activation2reactome: Interleukin-3, Interleukin-5 and GM-CSF signaling2reactome: Dectin-2 family2reactome: Regulation of signaling by CBL2reactome: Platelet activation, signaling and aggregation2reactome: C-type lectin receptors (CLRs)2reactome: Fcgamma receptor (FCGR) dependent phagocytosis

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
6850 SYK 1
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Gene in drug-gene network: Network Plot

Models in LRRK2-IN-1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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