iGMDRD21
Standard Name | CHEMBL | Pubchem CID | KEGG Drug ID | DRUGBANK ID | Drug Status | Drug targets (TTD) | Drug Type |
---|---|---|---|---|---|---|---|
Fluorouracil | CHEMBL185 | 3385 | D00584 | DB00544 | Alone | DAP000829 | Small Molecule |
Drug Class:
AntimetabolitesAntimetabolites, AntineoplasticAntineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 SubstratesCardiotoxic antineoplastic agentsCytochrome P-450 CYP1A2 SubstratesCytochrome P-450 CYP2C9 InhibitorsCytochrome P-450 CYP2C9 Inhibitors (strong)Cytochrome P-450 Enzyme InhibitorsFluoropyrimidinesHeterocyclic CompoundsHeterocyclic Compounds, 1-RingImmunologic FactorsImmunosuppressive AgentsMisc. Skin and Mucous Membrane AgentsMyelosuppressive AgentsNoxaeNucleoside Metabolic InhibitorPyrimidine AnaloguesPyrimidinesPyrimidinonesToxic ActionsUracilDrug Pathways:
Pyrimidine metabolismOne carbon pool by folateDrug metabolism - other enzymes Bile secretionDrug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
Gene ID | Gene Name | Model Num. |
---|---|---|
7514 | XPO1 | 1 |
4170 | MCL1 | 1 |
4851 | NOTCH1 | 1 |
25937 | WWTR1 | 1 |
4507 | MTAP | 1 |
6850 | SYK | 1 |
8452 | CUL3 | 1 |
7298 | TYMS | 1 |
7157 | TP53 | 2 |
4086 | SMAD1 | 1 |
7422 | VEGFA | 1 |
22943 | DKK1 | 1 |
10422 | UBAC1 | 1 |
4089 | SMAD4 | 1 |
54894 | RNF43 | 1 |
1956 | EGFR | 1 |
214 | ALCAM | 1 |
1806 | DPYD | 7 |
4524 | MTHFR | 7 |
171023 | ASXL1 | 1 |
1027 | CDKN1B | 1 |
6790 | AURKA | 1 |
5925 | RB1 | 1 |
1026 | CDKN1A | 1 |
3309 | HSPA5 | 1 |
10808 | HSPH1 | 2 |
6662 | SOX9 | 1 |
Gene in drug-gene network: Network Plot
Models in Fluorouracil