Summary: This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017].

dickkopf WNT signaling pathway inhibitor 1MIM:605189Ensembl:ENSG00000107984HGNC:HGNC:2891PA2734510q21.1

GO terms in DKK1

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCIDAGO:0005886plasma membrane
CCTASGO:0031901early endosome membrane
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0000904cell morphogenesis involved in differentiation
BPIEAGO:0001706endoderm formation
BPIEAGO:0001707mesoderm formation
BPIEAGO:0001942hair follicle development
BPIDAGO:0002090regulation of receptor internalization
BPISSGO:0007611learning or memory
BPIEAGO:0010469regulation of signaling receptor activity
BPIGIGO:0010628positive regulation of gene expression
BPISSGO:0010628positive regulation of gene expression
BPTASGO:0010942positive regulation of cell death
BPIDAGO:0030178negative regulation of Wnt signaling pathway
BPISSGO:0030279negative regulation of ossification
BPIEAGO:0030326embryonic limb morphogenesis
BPIEAGO:0030514negative regulation of BMP signaling pathway
BPIEAGO:0030900forebrain development
BPIDAGO:0032091negative regulation of protein binding
BPIEAGO:0032526response to retinoic acid
BPIDAGO:0033137negative regulation of peptidyl-serine phosphorylation
BPIDAGO:0042662negative regulation of mesodermal cell fate specification
BPIDAGO:0042663regulation of endodermal cell fate specification
BPISSGO:0043066negative regulation of apoptotic process
BPIDAGO:0043507positive regulation of JUN kinase activity
BPTASGO:0045813positive regulation of Wnt signaling pathway, calcium modulating pathway
BPIEAGO:0048642negative regulation of skeletal muscle tissue development
BPIEAGO:0050807regulation of synapse organization
BPIEAGO:0051966regulation of synaptic transmission, glutamatergic
BPISSGO:0060173limb development
BPIEAGO:0060325face morphogenesis
BPIDAGO:0060394negative regulation of pathway-restricted SMAD protein phosphorylation
BPIEAGO:0061743motor learning
BPISSGO:0090082positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
BPIBAGO:0090090negative regulation of canonical Wnt signaling pathway
BPIDAGO:0090090negative regulation of canonical Wnt signaling pathway
BPIGIGO:0090090negative regulation of canonical Wnt signaling pathway
BPNASGO:0090090negative regulation of canonical Wnt signaling pathway
BPTASGO:0090090negative regulation of canonical Wnt signaling pathway
BPIEAGO:0090244Wnt signaling pathway involved in somitogenesis
BPISSGO:0090647modulation of age-related behavioral decline
BPTASGO:0098883synapse disassembly
BPIEAGO:1900116extracellular negative regulation of signal transduction
BPISSGO:1901216positive regulation of neuron death
BPIDAGO:1901296negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
BPISSGO:1902949positive regulation of tau-protein kinase activity
BPTASGO:1904338regulation of dopaminergic neuron differentiation
BPIDAGO:1904723negative regulation of Wnt-Frizzled-LRP5/6 complex assembly
BPIPIGO:1904723negative regulation of Wnt-Frizzled-LRP5/6 complex assembly
BPTASGO:1904723negative regulation of Wnt-Frizzled-LRP5/6 complex assembly
BPIEAGO:1904958positive regulation of midbrain dopaminergic neuron differentiation
BPTASGO:2000096positive regulation of Wnt signaling pathway, planar cell polarity pathway
BPIDAGO:2000726negative regulation of cardiac muscle cell differentiation
MFIPIGO:0005515protein binding
MFTASGO:0008083growth factor activity
MFIBAGO:0039706co-receptor binding
MFIPIGO:0039706co-receptor binding
MFTASGO:0039706co-receptor binding
MFIBAGO:0048019receptor antagonist activity
MFIDAGO:0048019receptor antagonist activity
MFIDAGO:0050750low-density lipoprotein particle receptor binding

Gene expression in normal tissue: DKK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DKK1

DatabasePathway IDPathway Des.
wikipathwaysWP2406Cardiac Progenitor Differentiation
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
wikipathwaysWP2848Differentiation Pathway
wikipathwaysWP2853Endoderm Differentiation
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP3382POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
wikipathwaysWP3658Wnt-beta-catenin Signaling Pathway in Leukemia
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3930EDA Signalling in Hair Follicle Development
wikipathwaysWP3971Role of Osx and miRNAs in tooth development
wikipathwaysWP428Wnt Signaling Pathway
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
pidmyc_represspathwayValidated targets of C-MYC transcriptional repression
pidp53downstreampathwayDirect p53 effectors
pidps1pathwayPresenilin action in Notch and Wnt signaling
pidwnt_signaling_pathwayWnt signaling network
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
biocartagsk3pathwayinactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocartahespathwaysegmentation clock
biocartapitx2pathwaymulti-step regulation of transcription by pitx2
biocartawntlrp6pathwaywnt lrp6 signalling
biocartawntpathwaywnt signaling pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-3772470Negative regulation of TCF-dependent signaling by WNT ligand antagonists
reactomeR-HSA-4791275Signaling by WNT in cancer
reactomeR-HSA-5339717Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
reactomeR-HSA-5663202Diseases of signal transduction

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DKK1