DKK1
Summary: This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dickkopf WNT signaling pathway inhibitor 1 | MIM:605189 | Ensembl:ENSG00000107984 | HGNC:HGNC:2891 | PA27345 | 10q21.1 |
GO terms in DKK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0031901 | early endosome membrane |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0000904 | cell morphogenesis involved in differentiation |
| BP | IEA | GO:0001706 | endoderm formation |
| BP | IEA | GO:0001707 | mesoderm formation |
| BP | IEA | GO:0001942 | hair follicle development |
| BP | IDA | GO:0002090 | regulation of receptor internalization |
| BP | ISS | GO:0007611 | learning or memory |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IGI | GO:0010628 | positive regulation of gene expression |
| BP | ISS | GO:0010628 | positive regulation of gene expression |
| BP | TAS | GO:0010942 | positive regulation of cell death |
| BP | IDA | GO:0030178 | negative regulation of Wnt signaling pathway |
| BP | ISS | GO:0030279 | negative regulation of ossification |
| BP | IEA | GO:0030326 | embryonic limb morphogenesis |
| BP | IEA | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | IEA | GO:0030900 | forebrain development |
| BP | IDA | GO:0032091 | negative regulation of protein binding |
| BP | IEA | GO:0032526 | response to retinoic acid |
| BP | IDA | GO:0033137 | negative regulation of peptidyl-serine phosphorylation |
| BP | IDA | GO:0042662 | negative regulation of mesodermal cell fate specification |
| BP | IDA | GO:0042663 | regulation of endodermal cell fate specification |
| BP | ISS | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043507 | positive regulation of JUN kinase activity |
| BP | TAS | GO:0045813 | positive regulation of Wnt signaling pathway, calcium modulating pathway |
| BP | IEA | GO:0048642 | negative regulation of skeletal muscle tissue development |
| BP | IEA | GO:0050807 | regulation of synapse organization |
| BP | IEA | GO:0051966 | regulation of synaptic transmission, glutamatergic |
| BP | ISS | GO:0060173 | limb development |
| BP | IEA | GO:0060325 | face morphogenesis |
| BP | IDA | GO:0060394 | negative regulation of pathway-restricted SMAD protein phosphorylation |
| BP | IEA | GO:0061743 | motor learning |
| BP | ISS | GO:0090082 | positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway |
| BP | IBA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IDA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IGI | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | NAS | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | TAS | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:0090244 | Wnt signaling pathway involved in somitogenesis |
| BP | ISS | GO:0090647 | modulation of age-related behavioral decline |
| BP | TAS | GO:0098883 | synapse disassembly |
| BP | IEA | GO:1900116 | extracellular negative regulation of signal transduction |
| BP | ISS | GO:1901216 | positive regulation of neuron death |
| BP | IDA | GO:1901296 | negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment |
| BP | ISS | GO:1902949 | positive regulation of tau-protein kinase activity |
| BP | TAS | GO:1904338 | regulation of dopaminergic neuron differentiation |
| BP | IDA | GO:1904723 | negative regulation of Wnt-Frizzled-LRP5/6 complex assembly |
| BP | IPI | GO:1904723 | negative regulation of Wnt-Frizzled-LRP5/6 complex assembly |
| BP | TAS | GO:1904723 | negative regulation of Wnt-Frizzled-LRP5/6 complex assembly |
| BP | IEA | GO:1904958 | positive regulation of midbrain dopaminergic neuron differentiation |
| BP | TAS | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway |
| BP | IDA | GO:2000726 | negative regulation of cardiac muscle cell differentiation |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008083 | growth factor activity |
| MF | IBA | GO:0039706 | co-receptor binding |
| MF | IPI | GO:0039706 | co-receptor binding |
| MF | TAS | GO:0039706 | co-receptor binding |
| MF | IBA | GO:0048019 | receptor antagonist activity |
| MF | IDA | GO:0048019 | receptor antagonist activity |
| MF | IDA | GO:0050750 | low-density lipoprotein particle receptor binding |
Gene expression in normal tissue: DKK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DKK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP2848 | Differentiation Pathway |
| wikipathways | WP2853 | Endoderm Differentiation |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP3382 | POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation |
| wikipathways | WP3658 | Wnt-beta-catenin Signaling Pathway in Leukemia |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3930 | EDA Signalling in Hair Follicle Development |
| wikipathways | WP3971 | Role of Osx and miRNAs in tooth development |
| wikipathways | WP428 | Wnt Signaling Pathway |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | wnt_signaling_pathway | Wnt signaling network |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| netpath | Pathway_Wnt | Wnt |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | hespathway | segmentation clock |
| biocarta | pitx2pathway | multi-step regulation of transcription by pitx2 |
| biocarta | wntlrp6pathway | wnt lrp6 signalling |
| biocarta | wntpathway | wnt signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-3772470 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists |
| reactome | R-HSA-4791275 | Signaling by WNT in cancer |
| reactome | R-HSA-5339717 | Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD21 | Fluorouracil | 1 |
| iGMDRD80 | Irinotecan | 1 |
| iGMDRD368 | Oxaliplatin | 1 |
| iGMDRD122 | Levoleucovorin | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DKK1
CLASSFICATION
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