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iGMDRD122

Canonical SMILES: C1C(N(C2=C(N1)NC(=NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

InChI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12-,13-/m0/s1

InChI Key: VVIAGPKUTFNRDU-STQMWFEESA-N

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Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Standard NameLevoleucovorin CHEMBLCHEMBL1908841 Pubchem CID149436 DRUGBANK IDDB11596 Drug StatusAlone Drug TypeSmall Molecule

Drug Class:

Antidotes Biological Factors Coenzymes Detoxifying Agents for Antineoplastic Treatment Diet, Food, and Nutrition Enzymes and Coenzymes Folic Acid Food Food and Beverages Formyltetrahydrofolates Growth Substances Heterocyclic Compounds Heterocyclic Compounds, 2-Ring Leucovorin Leucovorin Calcium-Levoleucovorin Micronutrients Physiological Phenomena Pigments, Biological Protective Agents Pteridines Pterins Specialty Uses of Chemicals Tetrahydrofolates Vitamin B Complex Vitamins

Drug Targets:

glyA (P0A827)folA (P0ABQ4)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

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Gene ID	Gene Name	Model Num.
7422	VEGFA	1
22943	DKK1	1

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Gene in drug-gene network: Network Plot

Models in Levoleucovorin

	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
	UEXP(VEGFA)	gene	25973082	BOWEL	Colorectal Cancer	L-Folinic Acid	sensitivity	in vivo
	NC-EXP(DKK1)	gene	25788273	BOWEL	Colorectal Cancer	L-Folinic Acid	resistance or unresponsive	in vivo

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.