TYMS
Summary: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:188350 Ensembl IDEnsembl:ENSG00000176890 HGNC IDHGNC:HGNC:12441 PHARMGKB IDPA359 Map Location18p11.32 | |||||
GO terms in TYMS
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000166 | nucleotide binding |
| MF | IDA | GO:0000900 | translation repressor activity, mRNA regulatory element binding |
| MF | IDA | GO:0004799 | thymidylate synthase activity |
| MF | TAS | GO:0004799 | thymidylate synthase activity |
| MF | IC | GO:0005542 | folic acid binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: TYMS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TYMS
Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00046 | Pyrimidine Metabolism |
| smpdb | SMP00172 | Beta Ureidopropionase Deficiency |
| smpdb | SMP00178 | Dihydropyrimidinase Deficiency |
| smpdb | SMP00202 | MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) |
| smpdb | SMP00219 | UMP Synthase Deiciency (Orotic Aciduria) |
| smpdb | SMP00446 | Gemcitabine Action Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TYMS
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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