TYMS
Summary: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| thymidylate synthetase | MIM:188350 | Ensembl:ENSG00000176890 | HGNC:HGNC:12441 | PA359 | 18p11.32 |
GO terms in TYMS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000166 | nucleotide binding |
| MF | IDA | GO:0000900 | translation repressor activity, mRNA regulatory element binding |
| MF | IDA | GO:0004799 | thymidylate synthase activity |
| MF | TAS | GO:0004799 | thymidylate synthase activity |
| MF | IC | GO:0005542 | folic acid binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0048037 | cofactor binding |
| MF | IDA | GO:1990825 | sequence-specific mRNA binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | IEA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005743 | mitochondrial inner membrane |
| CC | IDA | GO:0005759 | mitochondrial matrix |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle |
| BP | IDA | GO:0006231 | dTMP biosynthetic process |
| BP | IEA | GO:0006235 | dTTP biosynthetic process |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0007623 | circadian rhythm |
| BP | TAS | GO:0015949 | nucleobase-containing small molecule interconversion |
| BP | IDA | GO:0017148 | negative regulation of translation |
| BP | IEA | GO:0019088 | immortalization of host cell by virus |
| BP | IEA | GO:0019860 | uracil metabolic process |
| BP | IEA | GO:0032259 | methylation |
| BP | IEA | GO:0032570 | response to progesterone |
| BP | IEA | GO:0033189 | response to vitamin A |
| BP | IEA | GO:0034097 | response to cytokine |
| BP | IDA | GO:0035999 | tetrahydrofolate interconversion |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IEA | GO:0046078 | dUMP metabolic process |
| BP | IEP | GO:0046683 | response to organophosphorus |
| BP | IEA | GO:0048589 | developmental growth |
| BP | IEA | GO:0051216 | cartilage development |
| BP | IEA | GO:0051384 | response to glucocorticoid |
| BP | IEA | GO:0051593 | response to folic acid |
| BP | IEA | GO:0060574 | intestinal epithelial cell maturation |
| BP | IC | GO:0071897 | DNA biosynthetic process |
| BP | IEA | GO:0097421 | liver regeneration |
Gene expression in normal tissue: TYMS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TYMS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00046 | Pyrimidine Metabolism |
| smpdb | SMP00172 | Beta Ureidopropionase Deficiency |
| smpdb | SMP00178 | Dihydropyrimidinase Deficiency |
| smpdb | SMP00202 | MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) |
| smpdb | SMP00219 | UMP Synthase Deiciency (Orotic Aciduria) |
| smpdb | SMP00446 | Gemcitabine Action Pathway |
| smpdb | SMP00469 | Capecitabine Action Pathway |
| smpdb | SMP00470 | Fluorouracil Action Pathway |
| smpdb | SMP00603 | Gemcitabine Metabolism Pathway |
| smpdb | SMP00607 | Capecitabine Metabolism Pathway |
| smpdb | SMP00608 | Fluorouracil Metabolism Pathway |
| wikipathways | WP1601 | Fluoropyrimidine Activity |
| wikipathways | WP1858 | Mitotic G1-G1-S phases |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP241 | One Carbon Metabolism |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP2525 | Trans-sulfuration and one carbon metabolism |
| wikipathways | WP3940 | One carbon metabolism and related pathways |
| wikipathways | WP3996 | Ethanol effects on histone modifications |
| wikipathways | WP4022 | Pyrimidine metabolism |
| pid | e2f_pathway | E2F transcription factor network |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa00670 | One carbon pool by folate - Homo sapiens (human) |
| pharmgkb | PA150653776 | Fluoropyrimidine Pathway, Pharmacokinetics |
| pharmgkb | PA165291507 | Fluoropyrimidine Pathway, Pharmacodynamics |
| pharmgkb | PA165291575 | Antimetabolite Pathway - Folate Cycle, Pharmacodynamics |
| pharmgkb | PA2039 | Methotrexate Pathway (Cancer Cell), Pharmacodynamics |
| pharmgkb | PA2040 | Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics |
| humancyc | PWY-7184 | pyrimidine deoxyribonucleotides de novo biosynthesis |
| humancyc | PWY-7199 | pyrimidine deoxyribonucleosides salvage |
| humancyc | PWY-7200 | superpathway of pyrimidine deoxyribonucleoside salvage |
| humancyc | PWY-7210 | pyrimidine deoxyribonucleotides biosynthesis from CTP |
| humancyc | PWY-7211 | superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis |
| humancyc | PWY66-385 | dTMP de novo biosynthesis (mitochondrial) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-15869 | Metabolism of nucleotides |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-499943 | Interconversion of nucleotide di- and triphosphates |
| reactome | R-HSA-539107 | Activation of E2F1 target genes at G1/S |
| reactome | R-HSA-69205 | G1/S-Specific Transcription |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD80 | Irinotecan | 1 |
| iGMDRD21 | Fluorouracil | 1 |
| iGMDRD102 | Raltitrexed | 1 |
| iGMDRD530 | MTX sodium | 1 |
| iGMDRD171 | Pemetrexed | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TYMS
CLASSFICATION
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