TYMS


Summary: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
thymidylate synthetaseMIM:188350Ensembl:ENSG00000176890HGNC:HGNC:12441PA35918p11.32

GO terms in TYMS


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000166nucleotide binding
MFIDAGO:0000900translation repressor activity, mRNA regulatory element binding
MFIDAGO:0004799thymidylate synthase activity
MFTASGO:0004799thymidylate synthase activity
MFICGO:0005542folic acid binding
MFIEAGO:0042803protein homodimerization activity
MFIEAGO:0048037cofactor binding
MFIDAGO:1990825sequence-specific mRNA binding
CCIDAGO:0005634nucleus
CCIEAGO:0005730nucleolus
CCIDAGO:0005737cytoplasm
CCIDAGO:0005739mitochondrion
CCIDAGO:0005743mitochondrial inner membrane
CCIDAGO:0005759mitochondrial matrix
CCTASGO:0005829cytosol
BPTASGO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle
BPIDAGO:0006231dTMP biosynthetic process
BPIEAGO:0006235dTTP biosynthetic process
BPIEAGO:0007568aging
BPIEAGO:0007623circadian rhythm
BPTASGO:0015949nucleobase-containing small molecule interconversion
BPIDAGO:0017148negative regulation of translation
BPIEAGO:0019088immortalization of host cell by virus
BPIEAGO:0019860uracil metabolic process
BPIEAGO:0032259methylation
BPIEAGO:0032570response to progesterone
BPIEAGO:0033189response to vitamin A
BPIEAGO:0034097response to cytokine
BPIDAGO:0035999tetrahydrofolate interconversion
BPIEAGO:0045471response to ethanol
BPIEAGO:0046078dUMP metabolic process
BPIEPGO:0046683response to organophosphorus
BPIEAGO:0048589developmental growth
BPIEAGO:0051216cartilage development
BPIEAGO:0051384response to glucocorticoid
BPIEAGO:0051593response to folic acid
BPIEAGO:0060574intestinal epithelial cell maturation
BPICGO:0071897DNA biosynthetic process
BPIEAGO:0097421liver regeneration

Gene expression in normal tissue: TYMS

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TYMS


DatabasePathway IDPathway Des.
smpdbSMP00046Pyrimidine Metabolism
smpdbSMP00172Beta Ureidopropionase Deficiency
smpdbSMP00178Dihydropyrimidinase Deficiency
smpdbSMP00202MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
smpdbSMP00219UMP Synthase Deiciency (Orotic Aciduria)
smpdbSMP00446Gemcitabine Action Pathway
smpdbSMP00469Capecitabine Action Pathway
smpdbSMP00470Fluorouracil Action Pathway
smpdbSMP00603Gemcitabine Metabolism Pathway
smpdbSMP00607Capecitabine Metabolism Pathway
smpdbSMP00608Fluorouracil Metabolism Pathway
wikipathwaysWP1601Fluoropyrimidine Activity
wikipathwaysWP1858Mitotic G1-G1-S phases
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP241One Carbon Metabolism
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP2525Trans-sulfuration and one carbon metabolism
wikipathwaysWP3940One carbon metabolism and related pathways
wikipathwaysWP3996Ethanol effects on histone modifications
wikipathwaysWP4022Pyrimidine metabolism
pide2f_pathwayE2F transcription factor network
kegghsa00240Pyrimidine metabolism - Homo sapiens (human)
kegghsa00670One carbon pool by folate - Homo sapiens (human)
pharmgkbPA150653776Fluoropyrimidine Pathway, Pharmacokinetics
pharmgkbPA165291507Fluoropyrimidine Pathway, Pharmacodynamics
pharmgkbPA165291575Antimetabolite Pathway - Folate Cycle, Pharmacodynamics
pharmgkbPA2039Methotrexate Pathway (Cancer Cell), Pharmacodynamics
pharmgkbPA2040Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics
humancycPWY-7184pyrimidine deoxyribonucleotides de novo biosynthesis
humancycPWY-7199pyrimidine deoxyribonucleosides salvage
humancycPWY-7200superpathway of pyrimidine deoxyribonucleoside salvage
humancycPWY-7210pyrimidine deoxyribonucleotides biosynthesis from CTP
humancycPWY-7211superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
humancycPWY66-385dTMP de novo biosynthesis (mitochondrial)
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-15869Metabolism of nucleotides
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-499943Interconversion of nucleotide di- and triphosphates
reactomeR-HSA-539107Activation of E2F1 target genes at G1/S
reactomeR-HSA-69205G1/S-Specific Transcription
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69278Cell Cycle, Mitotic

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD80Irinotecan1
iGMDRD21Fluorouracil1
iGMDRD102Raltitrexed1
iGMDRD530MTX sodium1
iGMDRD171Pemetrexed5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TYMS

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