NOTCH1
Summary: This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| notch 1 | MIM:190198 | Ensembl:ENSG00000148400 | HGNC:HGNC:7881 | PA31683 | 9q34.3 |
GO terms in NOTCH1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0001708 | cell fate specification |
| BP | ISS | GO:0001837 | epithelial to mesenchymal transition |
| BP | IEA | GO:0001889 | liver development |
| BP | ISS | GO:0001947 | heart looping |
| BP | IEA | GO:0002040 | sprouting angiogenesis |
| BP | IEA | GO:0002052 | positive regulation of neuroblast proliferation |
| BP | IEA | GO:0002437 | inflammatory response to antigenic stimulus |
| BP | IMP | GO:0003151 | outflow tract morphogenesis |
| BP | ISS | GO:0003157 | endocardium development |
| BP | ISS | GO:0003160 | endocardium morphogenesis |
| BP | IEA | GO:0003162 | atrioventricular node development |
| BP | ISS | GO:0003169 | coronary vein morphogenesis |
| BP | IMP | GO:0003180 | aortic valve morphogenesis |
| BP | ISS | GO:0003180 | aortic valve morphogenesis |
| BP | TAS | GO:0003180 | aortic valve morphogenesis |
| BP | ISS | GO:0003181 | atrioventricular valve morphogenesis |
| BP | IEA | GO:0003182 | coronary sinus valve morphogenesis |
| BP | IMP | GO:0003184 | pulmonary valve morphogenesis |
| BP | ISS | GO:0003184 | pulmonary valve morphogenesis |
| BP | IMP | GO:0003192 | mitral valve formation |
| BP | ISS | GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation |
| BP | ISS | GO:0003203 | endocardial cushion morphogenesis |
| BP | ISS | GO:0003207 | cardiac chamber formation |
| BP | ISS | GO:0003208 | cardiac ventricle morphogenesis |
| BP | ISS | GO:0003209 | cardiac atrium morphogenesis |
| BP | ISS | GO:0003213 | cardiac right atrium morphogenesis |
| BP | ISS | GO:0003214 | cardiac left ventricle morphogenesis |
| BP | IEA | GO:0003219 | cardiac right ventricle formation |
| BP | ISS | GO:0003222 | ventricular trabecula myocardium morphogenesis |
| BP | ISS | GO:0003241 | growth involved in heart morphogenesis |
| BP | ISS | GO:0003252 | negative regulation of cell proliferation involved in heart valve morphogenesis |
| BP | ISS | GO:0003256 | regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
| BP | IEA | GO:0003270 | Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation |
| BP | ISS | GO:0003273 | cell migration involved in endocardial cushion formation |
| BP | ISS | GO:0003332 | negative regulation of extracellular matrix constituent secretion |
| BP | ISS | GO:0003344 | pericardium morphogenesis |
| BP | TAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | NAS | GO:0006955 | immune response |
| BP | IEA | GO:0006959 | humoral immune response |
| BP | IDA | GO:0007050 | cell cycle arrest |
| BP | IDA | GO:0007219 | Notch signaling pathway |
| BP | IMP | GO:0007219 | Notch signaling pathway |
| BP | TAS | GO:0007219 | Notch signaling pathway |
| BP | ISS | GO:0007221 | positive regulation of transcription of Notch receptor target |
| BP | TAS | GO:0007221 | positive regulation of transcription of Notch receptor target |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | ISS | GO:0007368 | determination of left/right symmetry |
| BP | IEA | GO:0007386 | compartment pattern specification |
| BP | IEA | GO:0007409 | axonogenesis |
| BP | IEA | GO:0007440 | foregut morphogenesis |
| BP | IEA | GO:0007492 | endoderm development |
| BP | IMP | GO:0007507 | heart development |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0009912 | auditory receptor cell fate commitment |
| BP | ISS | GO:0010614 | negative regulation of cardiac muscle hypertrophy |
| BP | ISS | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0010629 | negative regulation of gene expression |
| BP | IMP | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| BP | IDA | GO:0010812 | negative regulation of cell-substrate adhesion |
| BP | ISS | GO:0010832 | negative regulation of myotube differentiation |
| BP | ISS | GO:0014031 | mesenchymal cell development |
| BP | IEA | GO:0014807 | regulation of somitogenesis |
| BP | IEA | GO:0021515 | cell differentiation in spinal cord |
| BP | IEA | GO:0021915 | neural tube development |
| BP | IEA | GO:0030216 | keratinocyte differentiation |
| BP | ISS | GO:0030279 | negative regulation of ossification |
| BP | IEA | GO:0030324 | lung development |
| BP | ISS | GO:0030335 | positive regulation of cell migration |
| BP | ISS | GO:0030513 | positive regulation of BMP signaling pathway |
| BP | ISS | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | IEA | GO:0030900 | forebrain development |
| BP | IEA | GO:0031069 | hair follicle morphogenesis |
| BP | IEA | GO:0031100 | animal organ regeneration |
| BP | IEA | GO:0031960 | response to corticosteroid |
| BP | IEA | GO:0032495 | response to muramyl dipeptide |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0035116 | embryonic hindlimb morphogenesis |
| BP | IMP | GO:0035148 | tube formation |
| BP | IEA | GO:0035914 | skeletal muscle cell differentiation |
| BP | IDA | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IEA | GO:0042246 | tissue regeneration |
| BP | ISS | GO:0043086 | negative regulation of catalytic activity |
| BP | IEA | GO:0045070 | positive regulation of viral genome replication |
| BP | IEA | GO:0045603 | positive regulation of endothelial cell differentiation |
| BP | IEA | GO:0045608 | negative regulation of inner ear auditory receptor cell differentiation |
| BP | IEA | GO:0045618 | positive regulation of keratinocyte differentiation |
| BP | IMP | GO:0045662 | negative regulation of myoblast differentiation |
| BP | ISS | GO:0045668 | negative regulation of osteoblast differentiation |
| BP | TAS | GO:0045747 | positive regulation of Notch signaling pathway |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0045955 | negative regulation of calcium ion-dependent exocytosis |
| BP | IDA | GO:0045967 | negative regulation of growth rate |
| BP | ISS | GO:0046427 | positive regulation of JAK-STAT cascade |
| BP | IEA | GO:0046533 | negative regulation of photoreceptor cell differentiation |
| BP | IDA | GO:0046579 | positive regulation of Ras protein signal transduction |
| BP | IEA | GO:0048103 | somatic stem cell division |
| BP | IEA | GO:0048708 | astrocyte differentiation |
| BP | IEA | GO:0048709 | oligodendrocyte differentiation |
| BP | ISS | GO:0048711 | positive regulation of astrocyte differentiation |
| BP | ISS | GO:0048715 | negative regulation of oligodendrocyte differentiation |
| BP | IEA | GO:0048754 | branching morphogenesis of an epithelial tube |
| BP | IEA | GO:0048873 | homeostasis of number of cells within a tissue |
| BP | IEA | GO:0050679 | positive regulation of epithelial cell proliferation |
| BP | ISS | GO:0050768 | negative regulation of neurogenesis |
| BP | ISS | GO:0055008 | cardiac muscle tissue morphogenesis |
| BP | IEA | GO:0060038 | cardiac muscle cell proliferation |
| BP | ISS | GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| BP | ISS | GO:0060253 | negative regulation of glial cell proliferation |
| BP | ISS | GO:0060271 | cilium assembly |
| BP | ISS | GO:0060317 | cardiac epithelial to mesenchymal transition |
| BP | ISS | GO:0060411 | cardiac septum morphogenesis |
| BP | IMP | GO:0060412 | ventricular septum morphogenesis |
| BP | IEA | GO:0060528 | secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development |
| BP | IEA | GO:0060740 | prostate gland epithelium morphogenesis |
| BP | IEA | GO:0060768 | regulation of epithelial cell proliferation involved in prostate gland development |
| BP | ISS | GO:0060842 | arterial endothelial cell differentiation |
| BP | ISS | GO:0060843 | venous endothelial cell differentiation |
| BP | ISS | GO:0060948 | cardiac vascular smooth muscle cell development |
| BP | ISS | GO:0060956 | endocardial cell differentiation |
| BP | ISS | GO:0060979 | vasculogenesis involved in coronary vascular morphogenesis |
| BP | ISS | GO:0060982 | coronary artery morphogenesis |
| BP | IMP | GO:0061314 | Notch signaling involved in heart development |
| BP | ISS | GO:0061384 | heart trabecula morphogenesis |
| BP | ISS | GO:0061419 | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| BP | ISS | GO:0070168 | negative regulation of biomineral tissue development |
| BP | IDA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0070986 | left/right axis specification |
| BP | IDA | GO:0071372 | cellular response to follicle-stimulating hormone stimulus |
| BP | IEA | GO:0072017 | distal tubule development |
| BP | IEA | GO:0072044 | collecting duct development |
| BP | IEA | GO:0072144 | glomerular mesangial cell development |
| BP | IEA | GO:0072602 | interleukin-4 secretion |
| BP | IDA | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis |
| BP | IEA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IEP | GO:0097150 | neuronal stem cell population maintenance |
| BP | ISS | GO:1901201 | regulation of extracellular matrix assembly |
| BP | IEA | GO:1902263 | apoptotic process involved in embryonic digit morphogenesis |
| BP | ISS | GO:1902339 | positive regulation of apoptotic process involved in morphogenesis |
| BP | IEA | GO:1903849 | positive regulation of aorta morphogenesis |
| BP | IMP | GO:2000737 | negative regulation of stem cell differentiation |
| BP | IMP | GO:2000811 | negative regulation of anoikis |
| BP | ISS | GO:2000974 | negative regulation of pro-B cell differentiation |
| BP | IDA | GO:2001027 | negative regulation of endothelial cell chemotaxis |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0001669 | acrosomal vesicle |
| CC | IDA | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex |
| CC | TAS | GO:0005576 | extracellular region |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005912 | adherens junction |
| CC | IEA | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | ISS | GO:0016324 | apical plasma membrane |
| CC | IDA | GO:0043235 | receptor complex |
| MF | ISS | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISS | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding |
| MF | IEA | GO:0003700 | DNA-binding transcription factor activity |
| MF | ISS | GO:0004857 | enzyme inhibitor activity |
| MF | IEA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IEA | GO:0005112 | Notch binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0019899 | enzyme binding |
| MF | IEA | GO:0031490 | chromatin DNA binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: NOTCH1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NOTCH1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1591 | Heart Development |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2361 | Gastric Cancer Network 1 |
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP2786 | Pre-NOTCH Expression and Processing |
| wikipathways | WP2848 | Differentiation Pathway |
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| wikipathways | WP2853 | Endoderm Differentiation |
| wikipathways | WP2854 | Gene regulatory network modelling somitogenesis |
| wikipathways | WP3413 | NOTCH1 regulation of human endothelial cell calcification |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| wikipathways | WP3678 | Amplification and Expansion of Oncogenic Pathways as Metastatic Traits |
| wikipathways | WP3845 | Canonical and Non-canonical Notch signaling |
| wikipathways | WP3927 | BMP Signaling Pathway in Eyelid Development |
| wikipathways | WP3971 | Role of Osx and miRNAs in tooth development |
| wikipathways | WP4147 | PTF1A related regulatory pathway |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP61 | Notch Signaling Pathway |
| netpath | Pathway_Notch | Notch |
| pid | deltanp63pathway | Validated transcriptional targets of deltaNp63 isoforms |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | notch_pathway | Notch signaling pathway |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05020 | Prion diseases - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| biocarta | notchpathway | proteolysis and signaling pathway of notch |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-186712 | Regulation of beta-cell development |
| reactome | R-HSA-1912399 | Pre-NOTCH Processing in the Endoplasmic Reticulum |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912408 | Pre-NOTCH Transcription and Translation |
| reactome | R-HSA-1912420 | Pre-NOTCH Processing in Golgi |
| reactome | R-HSA-1912420 | Pre-NOTCH Processing in Golgi |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-1912422 | Pre-NOTCH Expression and Processing |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-210744 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus |
| reactome | R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644605 | FBXW7 Mutants and NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2644607 | Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling |
| reactome | R-HSA-2660825 | Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant |
| reactome | R-HSA-2660826 | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant |
| reactome | R-HSA-2691230 | Signaling by NOTCH1 HD Domain Mutants in Cancer |
| reactome | R-HSA-2691232 | Constitutive Signaling by NOTCH1 HD Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-350054 | Notch-HLH transcription pathway |
| reactome | R-HSA-3781865 | Diseases of glycosylation |
| reactome | R-HSA-3906995 | Diseases associated with O-glycosylation of proteins |
| reactome | R-HSA-5083630 | Defective LFNG causes SCDO3 |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8941856 | RUNX3 regulates NOTCH signaling |
| reactome | R-HSA-8941856 | RUNX3 regulates NOTCH signaling |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-9013694 | Signaling by NOTCH4 |
| reactome | R-HSA-9013695 | NOTCH4 Intracellular Domain Regulates Transcription |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD680 | RO4929097 | 4 |
| iGMDRD178 | MG-132 | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD351 | GW843682X | 6 |
| iGMDRD651 | PF-03084014 | 4 |
| iGMDRD84 | Lovastatin acid | 6 |
| iGMDRD412 | VX-702 | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD246 | NPC26 | 1 |
| iGMDRD882 | CIL41 | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD565 | BI-D1870 | 1 |
| iGMDRD88 | AICA ribonucleotide | 2 |
| iGMDRD558 | CAY10603 | 1 |
| iGMDRD386 | TAK-715 | 1 |
| iGMDRD181 | CDK4 inhibitor | 3 |
| iGMDRD378 | ZM-447439 | 1 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD163 | all trans Retinoic Acid | 1 |
| iGMDRD253 | Vincaleukoblastine | 1 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD608 | Refametinib | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 3 |
| iGMDRD328 | AR-42 | 1 |
| iGMDRD239 | Dasatinib | 1 |
| iGMDRD136 | Nutlin-3 | 1 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD332 | A-770041 | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD666 | LGK974 | 1 |
| iGMDRD134 | Sorafenib | 1 |
| iGMDRD255 | SB225002 | 8 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD50 | Cytarabine | 1 |
| iGMDRD27 | WHI-P97 | 1 |
| iGMDRD964 | OMP-59R5 | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD370 | TPCA-1 | 1 |
| iGMDRD564 | GSK-650394 | 1 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD957 | NOTCH1 Antibody | 1 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD662 | JQ-1 | 1 |
| iGMDRD396 | AS601245 | 1 |
| iGMDRD343 | MK-0752 | 7 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD525 | Gamma secretase inhibitor | 27 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD293 | Bleomycin | 1 |
| iGMDRD949 | mTOR inhibitor | 3 |
| iGMDRD198 | AC1LE7KD | 1 |
| iGMDRD21 | Fluorouracil | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD403 | BAY 61-3606 | 1 |
| iGMDRD476 | WH-4-023 | 1 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD654 | SL 0101-1 | 1 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD1012 | steroids early setting | 6 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD602 | Foretinib | 1 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD284 | Palbociclib | 2 |
| iGMDRD493 | GSK269962A | 1 |
| iGMDRD568 | SCHEMBL15005512 | 1 |
| iGMDRD963 | OMP-52M51 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NOTCH1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.