Summary: This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011].

activated leukocyte cell adhesion moleculeMIM:601662Ensembl:ENSG00000170017HGNC:HGNC:400PA246913q13.11

GO terms in ALCAM

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
CCIDAGO:0001772immunological synapse
CCISSGO:0005887integral component of plasma membrane
CCHDAGO:0005925focal adhesion
CCIEAGO:0009897external side of plasma membrane
CCIDAGO:0031226intrinsic component of plasma membrane
CCIDAGO:0042101T cell receptor complex
CCIEAGO:0043025neuronal cell body
CCHDAGO:0070062extracellular exosome
BPIEAGO:0002250adaptive immune response
BPISSGO:0007155cell adhesion
BPIMPGO:0007157heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
BPTASGO:0007165signal transduction
BPIEAGO:0008045motor neuron axon guidance
BPISSGO:0031290retinal ganglion cell axon guidance
BPISSGO:0048846axon extension involved in axon guidance
BPISSGO:1990138neuron projection extension

Gene expression in normal tissue: ALCAM

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ALCAM

DatabasePathway IDPathway Des.
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-422475Axon guidance

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ALCAM