ALCAM
Summary: This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| activated leukocyte cell adhesion molecule | MIM:601662 | Ensembl:ENSG00000170017 | HGNC:HGNC:400 | PA24691 | 3q13.11 |
GO terms in ALCAM
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| CC | IDA | GO:0001772 | immunological synapse |
| CC | ISS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | ISS | GO:0030424 | axon |
| CC | IEA | GO:0030425 | dendrite |
| CC | IDA | GO:0031226 | intrinsic component of plasma membrane |
| CC | IDA | GO:0042101 | T cell receptor complex |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | ISS | GO:0007155 | cell adhesion |
| BP | IMP | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0008045 | motor neuron axon guidance |
| BP | ISS | GO:0031290 | retinal ganglion cell axon guidance |
| BP | ISS | GO:0048846 | axon extension involved in axon guidance |
| BP | ISS | GO:1990138 | neuron projection extension |
Gene expression in normal tissue: ALCAM
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ALCAM
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ALCAM
CLASSFICATION
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