HSPA5

Summary: The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameheat shock protein family A (Hsp70) member 5
OMIM IDMIM:138120
Ensembl IDEnsembl:ENSG00000044574
HGNC IDHGNC:HGNC:5238
PHARMGKB IDPA29504
Map Location9q33.3

GO terms in HSPA5


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0006983 ER overload response
BP IBA GO:0006986 response to unfolded protein
BP IEA GO:0010976 positive regulation of neuron projection development
BP IEA GO:0021589 cerebellum structural organization
BP IEA GO:0021680 cerebellar Purkinje cell layer development
BP HEP GO:0021762 substantia nigra development
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Gene expression in normal tissue: HSPA5

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Cancer model num: 1

Gene-drug pathway distribution

Protein stability and degradation1Bile secretion1

Pathways in HSPA5


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Database
Pathway ID
Pathway Des.
kegg hsa03060 Protein export - Homo sapiens (human)
kegg hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegg hsa04612 Antigen processing and presentation - Homo sapiens (human)
kegg hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
kegg hsa05020 Prion diseases - Homo sapiens (human)
netpath Pathway_AndrogenReceptor AndrogenReceptor
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD21 Fluorouracil 1
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSPA5

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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