HSPA5
Summary: The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| heat shock protein family A (Hsp70) member 5 | MIM:138120 | Ensembl:ENSG00000044574 | HGNC:HGNC:5238 | PA29504 | 9q33.3 |
GO terms in HSPA5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006983 | ER overload response |
| BP | IBA | GO:0006986 | response to unfolded protein |
| BP | IEA | GO:0010976 | positive regulation of neuron projection development |
| BP | IEA | GO:0021589 | cerebellum structural organization |
| BP | IEA | GO:0021680 | cerebellar Purkinje cell layer development |
| BP | HEP | GO:0021762 | substantia nigra development |
| BP | IEA | GO:0030182 | neuron differentiation |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IBA | GO:0030433 | ubiquitin-dependent ERAD pathway |
| BP | TAS | GO:0030433 | ubiquitin-dependent ERAD pathway |
| BP | IEA | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | IBA | GO:0030968 | endoplasmic reticulum unfolded protein response |
| BP | TAS | GO:0030968 | endoplasmic reticulum unfolded protein response |
| BP | IEA | GO:0031398 | positive regulation of protein ubiquitination |
| BP | IBA | GO:0034605 | cellular response to heat |
| BP | IBA | GO:0034620 | cellular response to unfolded protein |
| BP | TAS | GO:0034975 | protein folding in endoplasmic reticulum |
| BP | IMP | GO:0035437 | maintenance of protein localization in endoplasmic reticulum |
| BP | IEA | GO:0035690 | cellular response to drug |
| BP | TAS | GO:0036498 | IRE1-mediated unfolded protein response |
| BP | TAS | GO:0036499 | PERK-mediated unfolded protein response |
| BP | TAS | GO:0036500 | ATF6-mediated unfolded protein response |
| BP | IBA | GO:0042026 | protein refolding |
| BP | IDA | GO:0042149 | cellular response to glucose starvation |
| BP | IEA | GO:0042220 | response to cocaine |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0051085 | chaperone cofactor-dependent protein refolding |
| BP | IEA | GO:0051402 | neuron apoptotic process |
| BP | TAS | GO:0060904 | regulation of protein folding in endoplasmic reticulum |
| BP | IEA | GO:0071236 | cellular response to antibiotic |
| BP | IEA | GO:0071277 | cellular response to calcium ion |
| BP | IEA | GO:0071287 | cellular response to manganese ion |
| BP | IEA | GO:0071320 | cellular response to cAMP |
| BP | IEA | GO:0071353 | cellular response to interleukin-4 |
| BP | IEA | GO:0071480 | cellular response to gamma radiation |
| BP | ISS | GO:0090074 | negative regulation of protein homodimerization activity |
| BP | TAS | GO:0090074 | negative regulation of protein homodimerization activity |
| BP | IEA | GO:0097501 | stress response to metal ion |
| BP | IEA | GO:1901998 | toxin transport |
| BP | TAS | GO:1903891 | regulation of ATF6-mediated unfolded protein response |
| BP | TAS | GO:1903894 | regulation of IRE1-mediated unfolded protein response |
| BP | ISS | GO:1903895 | negative regulation of IRE1-mediated unfolded protein response |
| BP | TAS | GO:1903897 | regulation of PERK-mediated unfolded protein response |
| BP | IEA | GO:1904313 | response to methamphetamine hydrochloride |
| BP | IEA | GO:1990090 | cellular response to nerve growth factor stimulus |
| BP | TAS | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress |
| CC | HDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005634 | nucleus |
| CC | IMP | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IMP | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0005790 | smooth endoplasmic reticulum |
| CC | IDA | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0008180 | COP9 signalosome |
| CC | IEA | GO:0009986 | cell surface |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0016020 | membrane |
| CC | IDA | GO:0030176 | integral component of endoplasmic reticulum membrane |
| CC | IDA | GO:0030496 | midbody |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IBA | GO:0034663 | endoplasmic reticulum chaperone complex |
| CC | IDA | GO:0034663 | endoplasmic reticulum chaperone complex |
| CC | IEA | GO:0042470 | melanosome |
| CC | IEA | GO:0043209 | myelin sheath |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | TAS | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005524 | ATP binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0016887 | ATPase activity |
| MF | IDA | GO:0016887 | ATPase activity |
| MF | ISS | GO:0016887 | ATPase activity |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IBA | GO:0031072 | heat shock protein binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IBA | GO:0042623 | ATPase activity, coupled |
| MF | IEA | GO:0043022 | ribosome binding |
| MF | IBA | GO:0044183 | protein binding involved in protein folding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IBA | GO:0051082 | unfolded protein binding |
| MF | TAS | GO:0051082 | unfolded protein binding |
| MF | TAS | GO:0051087 | chaperone binding |
| MF | IBA | GO:0051787 | misfolded protein binding |
| MF | IDA | GO:0051787 | misfolded protein binding |
Gene expression in normal tissue: HSPA5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSPA5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03060 | Protein export - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa04612 | Antigen processing and presentation - Homo sapiens (human) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa05020 | Prion diseases - Homo sapiens (human) |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_TSH | TSH |
| wikipathways | WP2359 | Parkin-Ubiquitin Proteasomal System pathway |
| wikipathways | WP2655 | ATF6 (ATF6-alpha) activates chaperone genes |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP3613 | Photodynamic therapy-induced unfolded protein response |
| wikipathways | WP3995 | Prion disease pathway |
| smpdb | SMP00074 | Retinol Metabolism |
| smpdb | SMP00086 | Ibuprofen Action Pathway |
| smpdb | SMP00327 | Phenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00336 | Vitamin A Deficiency |
| smpdb | SMP00406 | Morphine Action Pathway |
| smpdb | SMP00433 | Irinotecan Action Pathway |
| smpdb | SMP00442 | Etoposide Action Pathway |
| smpdb | SMP00590 | Ibuprofen Metabolism Pathway |
| smpdb | SMP00600 | Irinotecan Metabolism Pathway |
| smpdb | SMP00601 | Etoposide Metabolism Pathway |
| smpdb | SMP00622 | Morphine Metabolism Pathway |
| smpdb | SMP00640 | Acetaminophen Metabolism Pathway |
| smpdb | SMP00648 | Sorafenib Metabolism Pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-381033 | ATF6 (ATF6-alpha) activates chaperones |
| reactome | R-HSA-381042 | PERK regulates gene expression |
| reactome | R-HSA-381070 | IRE1alpha activates chaperones |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-381183 | ATF6 (ATF6-alpha) activates chaperone genes |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| reactome | R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| reactome | R-HSA-983170 | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| biocarta | prionpathway | prion pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSPA5
CLASSFICATION
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