AURKA
Summary: The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameaurora kinase A OMIM IDMIM:603072 Ensembl IDEnsembl:ENSG00000087586 HGNC IDHGNC:HGNC:11393 PHARMGKB IDPA36201 Map Location20q13.2 | |||||
GO terms in AURKA
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0000278 | mitotic cell cycle |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | IMP | GO:0007051 | spindle organization |
| BP | IBA | GO:0007052 | mitotic spindle organization |
Gene expression in normal tissue: AURKA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AURKA
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-2990846 | SUMOylation |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AURKA
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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