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DPYD

Summary: The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namedihydropyrimidine dehydrogenase OMIM IDMIM:612779 Ensembl IDEnsembl:ENSG00000188641 HGNC IDHGNC:HGNC:3012 PHARMGKB IDPA145 Map Location1p21.3

Gene Categories:

DRUGGABLE GENOME

GO terms in DPYD

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity
MF	IDA	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity
MF	IMP	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity
MF	ISS	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity
MF	TAS	GO:0017113	dihydropyrimidine dehydrogenase (NADP+) activity

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Gene expression in normal tissue: DPYD

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DPYD

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Database	Pathway ID	Pathway Des.
pharmgkb	PA150653776	Fluoropyrimidine Pathway, Pharmacokinetics
kegg	hsa00240	Pyrimidine metabolism - Homo sapiens (human)
kegg	hsa00410	beta-Alanine metabolism - Homo sapiens (human)
kegg	hsa00770	Pantothenate and CoA biosynthesis - Homo sapiens (human)
kegg	hsa00983	Drug metabolism - other enzymes - Homo sapiens (human)
humancyc	PWY-3982	uracil degradation

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD61	Kinetin riboside	2
iGMDRD21	Fluorouracil	7
iGMDRD152	179324-69-7	3
iGMDRD85	Ursolic acid	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DPYD

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.