iGMDRD43


Canonical SMILES: C1CC(OC1)N2C=C(C(=O)NC2=O)F

InChI: InChI=1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)

InChI Key: WFWLQNSHRPWKFK-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameTegafur
Pubchem CID5386
DRUGBANK IDDB09256
Drug StatusAlone
Drug TypeSmall Molecule


Drug Targets:

TYMS (P04818)

Drug-model tissue-cancer distribution: Bubble Plot

OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 7

Drug-gene pathway enrichments

1smpdb: Carnosinuria, carnosinemia1wikipathways: Fluoropyrimidine Activity1smpdb: Ureidopropionase deficiency1smpdb: GABA-Transaminase Deficiency1smpdb: UMP Synthase Deiciency (Orotic Aciduria)1wikipathways: TYROBP Causal Network1wikipathways: Pyrimidine metabolism1reactome: Nucleobase catabolism1reactome: Pyrimidine catabolism1reactome: Metabolism of nucleotides

Drug-gene GO enrichments

5MF: dihydropyrimidine dehydrogenase (NADP+) activity2CC: cytosol2BP: uracil catabolic process2BP: pyrimidine nucleobase catabolic process2MF: protein homodimerization activity1BP: beta-alanine biosynthetic process1BP: pyrimidine nucleoside catabolic process1CC: cytoplasm1BP: thymidine catabolic process1BP: oxidation-reduction process

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
1806 DPYD 7
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Gene in drug-gene network: Network Plot

Models in Tegafur

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
BIA-IA(DPYD) gene 23988873 OTHER Cancer of Unknown Primary (CUP) Tegafur Increased Toxicity in vivo
SPDV(DPYD) gene 23988873 OTHER Cancer of Unknown Primary (CUP) Tegafur Increased Toxicity in vivo
SNV(DPYD I560S) gene 23988873 OTHER Cancer of Unknown Primary (CUP) Tegafur Increased Toxicity in vivo
SNV(DPYD D949V) gene 23988873 OTHER Cancer of Unknown Primary (CUP) Tegafur Increased Toxicity in vivo
GT(DPYD DPYD*2A) gene 23988873 OTHER Cancer of Unknown Primary (CUP) Tegafur Adverse sensitivity in vivo
GT(DPYD DPYD*13) gene 23988873 OTHER Cancer of Unknown Primary (CUP) Tegafur Adverse sensitivity in vivo
GT(DPYD rs67376798) gene 23988873 OTHER Cancer of Unknown Primary (CUP) Tegafur Adverse sensitivity in vivo
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