MTAP
Summary: This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:156540 Ensembl IDEnsembl:ENSG00000099810 HGNC IDHGNC:HGNC:7413 PHARMGKB IDPA31220 Map Location9p21.3 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in MTAP
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004645 | phosphorylase activity |
| MF | IBA | GO:0004731 | purine-nucleoside phosphorylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0017061 | S-methyl-5-thioadenosine phosphorylase activity |
| MF | TAS | GO:0017061 | S-methyl-5-thioadenosine phosphorylase activity |
| CC | IEA | GO:0005634 | nucleus |
Gene expression in normal tissue: MTAP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MTAP
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PWY-6756 | S-methyl-5,-thioadenosine degradation |
| humancyc | PWY-7527 | methionine salvage cycle III |
| kegg | hsa00270 | Cysteine and methionine metabolism - Homo sapiens (human) |
| wikipathways | WP3580 | Methionine De Novo and Salvage Pathway |
| wikipathways | WP4100 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| smpdb | SMP00033 | Methionine Metabolism |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD21 | Fluorouracil | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MTAP
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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