CDKN1B
Summary: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600778 Ensembl IDEnsembl:ENSG00000111276 HGNC IDHGNC:HGNC:1785 PHARMGKB IDPA105 Map Location12p13.1 | |||||
GO terms in CDKN1B
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | EXP | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IMP | GO:0004860 | protein kinase inhibitor activity |
| MF | IBA | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| MF | IDA | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| MF | TAS | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| MF | TAS | GO:0005072 | transforming growth factor beta receptor, cytoplasmic mediator activity |
Gene expression in normal tissue: CDKN1B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDKN1B
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP1545 | miRNAs involved in DNA damage response |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP1971 | Integrated Cancer Pathway |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDKN1B
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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