CDKN1B


Summary: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014].

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OMIM ID
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GO terms in CDKN1B


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Term Type
Evidence Type
GO Term ID
GO Des.
MF EXP GO:0004693 cyclin-dependent protein serine/threonine kinase activity
MF IMP GO:0004860 protein kinase inhibitor activity
MF IBA GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
MF IDA GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
MF TAS GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity
MF TAS GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity
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Gene expression in normal tissue: CDKN1B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CDKN1B


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Database
Pathway ID
Pathway Des.
wikipathways WP1530 miRNA Regulation of DNA Damage Response
wikipathways WP1545 miRNAs involved in DNA damage response
wikipathways WP179 Cell Cycle
wikipathways WP1971 Integrated Cancer Pathway
wikipathways WP2002 miR-targeted genes in epithelium - TarBase
wikipathways WP2004 miR-targeted genes in lymphocytes - TarBase
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD264 Bryostatin 1 1
iGMDRD399 Selumetinib 1
iGMDRD133 Lapatinib 1
iGMDRD146 Elesclomol 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDKN1B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
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No matching records found

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