EGFR
Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| epidermal growth factor receptor | MIM:131550 | Ensembl:ENSG00000146648 | HGNC:HGNC:3236 | PA7360 | 7p11.2 |
GO terms in EGFR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | NAS | GO:0005615 | extracellular space |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005768 | endosome |
| CC | IDA | GO:0005768 | endosome |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IBA | GO:0009925 | basal plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0010008 | endosome membrane |
| CC | IDA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | TAS | GO:0030122 | AP-2 adaptor complex |
| CC | TAS | GO:0030665 | clathrin-coated vesicle membrane |
| CC | IDA | GO:0031901 | early endosome membrane |
| CC | IEA | GO:0031965 | nuclear membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0043235 | receptor complex |
| CC | IDA | GO:0045121 | membrane raft |
| CC | IEA | GO:0045202 | synapse |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | ISS | GO:0070435 | Shc-EGFR complex |
| CC | IDA | GO:0097489 | multivesicular body, internal vesicle lumen |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000186 | activation of MAPKK activity |
| BP | NAS | GO:0001503 | ossification |
| BP | IEA | GO:0001892 | embryonic placenta development |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0001942 | hair follicle development |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006412 | translation |
| BP | IEA | GO:0006970 | response to osmotic stress |
| BP | IDA | GO:0007165 | signal transduction |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IDA | GO:0007166 | cell surface receptor signaling pathway |
| BP | IDA | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | IMP | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0007202 | activation of phospholipase C activity |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007435 | salivary gland morphogenesis |
| BP | IEA | GO:0007494 | midgut development |
| BP | ISS | GO:0007611 | learning or memory |
| BP | IEA | GO:0007623 | circadian rhythm |
| BP | IDA | GO:0008283 | cell proliferation |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IDA | GO:0010750 | positive regulation of nitric oxide mediated signal transduction |
| BP | IEA | GO:0010960 | magnesium ion homeostasis |
| BP | IMP | GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0016101 | diterpenoid metabolic process |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0021795 | cerebral cortex cell migration |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0030307 | positive regulation of cell growth |
| BP | IEA | GO:0030324 | lung development |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IDA | GO:0031659 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle |
| BP | IEA | GO:0032930 | positive regulation of superoxide anion generation |
| BP | IMP | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IEA | GO:0033590 | response to cobalamin |
| BP | IEA | GO:0033594 | response to hydroxyisoflavone |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IMP | GO:0034614 | cellular response to reactive oxygen species |
| BP | IMP | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | TAS | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | TAS | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| BP | IEA | GO:0042060 | wound healing |
| BP | IDA | GO:0042177 | negative regulation of protein catabolic process |
| BP | IDA | GO:0042327 | positive regulation of phosphorylation |
| BP | IEA | GO:0042698 | ovulation cycle |
| BP | IEA | GO:0042743 | hydrogen peroxide metabolic process |
| BP | TAS | GO:0043006 | activation of phospholipase A2 activity by calcium-mediated signaling |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IEA | GO:0043586 | tongue development |
| BP | IDA | GO:0045739 | positive regulation of DNA repair |
| BP | IDA | GO:0045740 | positive regulation of DNA replication |
| BP | TAS | GO:0045746 | negative regulation of Notch signaling pathway |
| BP | IEA | GO:0045780 | positive regulation of bone resorption |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0045907 | positive regulation of vasoconstriction |
| BP | IEA | GO:0045930 | negative regulation of mitotic cell cycle |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0046328 | regulation of JNK cascade |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IMP | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IEA | GO:0048143 | astrocyte activation |
| BP | IEA | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | IEA | GO:0048546 | digestive tract morphogenesis |
| BP | IEA | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0048812 | neuron projection morphogenesis |
| BP | IDA | GO:0050679 | positive regulation of epithelial cell proliferation |
| BP | IEA | GO:0050729 | positive regulation of inflammatory response |
| BP | IMP | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation |
| BP | IDA | GO:0050999 | regulation of nitric-oxide synthase activity |
| BP | TAS | GO:0051205 | protein insertion into membrane |
| BP | IEA | GO:0051592 | response to calcium ion |
| BP | IMP | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0051968 | positive regulation of synaptic transmission, glutamatergic |
| BP | IEA | GO:0060571 | morphogenesis of an epithelial fold |
| BP | TAS | GO:0061024 | membrane organization |
| BP | IEA | GO:0061029 | eyelid development in camera-type eye |
| BP | IDA | GO:0070141 | response to UV-A |
| BP | IMP | GO:0070372 | regulation of ERK1 and ERK2 cascade |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071230 | cellular response to amino acid stimulus |
| BP | IEA | GO:0071260 | cellular response to mechanical stimulus |
| BP | IMP | GO:0071276 | cellular response to cadmium ion |
| BP | ISS | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | IDA | GO:0071392 | cellular response to estradiol stimulus |
| BP | IEA | GO:0071549 | cellular response to dexamethasone stimulus |
| BP | IMP | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:0097421 | liver regeneration |
| BP | IEA | GO:0097755 | positive regulation of blood vessel diameter |
| BP | IMP | GO:0098609 | cell-cell adhesion |
| BP | IDA | GO:1900020 | positive regulation of protein kinase C activity |
| BP | TAS | GO:1901185 | negative regulation of ERBB signaling pathway |
| BP | IMP | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| BP | IEA | GO:1902722 | positive regulation of prolactin secretion |
| BP | IDA | GO:1903078 | positive regulation of protein localization to plasma membrane |
| BP | IMP | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA |
| BP | IMP | GO:1905208 | negative regulation of cardiocyte differentiation |
| BP | TAS | GO:2000145 | regulation of cell motility |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | NAS | GO:0003690 | double-stranded DNA binding |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | NAS | GO:0004709 | MAP kinase kinase kinase activity |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | IMP | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | TAS | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IDA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IBA | GO:0005006 | epidermal growth factor-activated receptor activity |
| MF | IDA | GO:0005006 | epidermal growth factor-activated receptor activity |
| MF | IMP | GO:0005006 | epidermal growth factor-activated receptor activity |
| MF | NAS | GO:0005006 | epidermal growth factor-activated receptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IEA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | IDA | GO:0030235 | nitric-oxide synthase regulator activity |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
| MF | IBA | GO:0048408 | epidermal growth factor binding |
| MF | IEA | GO:0048408 | epidermal growth factor binding |
| MF | IDA | GO:0051015 | actin filament binding |
Gene expression in normal tissue: EGFR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EGFR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP00463 | Phosphatidylinositol Phosphate Metabolism |
| smpdb | SMP00472 | Erlotinib Action Pathway |
| smpdb | SMP00473 | Gefitinib Action Pathway |
| smpdb | SMP00474 | Cetuximab Action Pathway |
| smpdb | SMP00475 | Panitumumab Action Pathway |
| smpdb | SMP00476 | Trastuzumab Action Pathway |
| smpdb | SMP00582 | Joubert syndrome |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2363 | Gastric Cancer Network 2 |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2586 | Aryl Hydrocarbon Receptor |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2804 | Hair Follicle Development- Induction (Part 1 of 3) |
| wikipathways | WP2828 | Bladder Cancer |
| wikipathways | WP2868 | TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer |
| wikipathways | WP2870 | Extracellular vesicle-mediated signaling in recipient cells |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3853 | ERK Pathway in Huntington,s Disease |
| wikipathways | WP3927 | BMP Signaling Pathway in Eyelid Development |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP4086 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP673 | ErbB Signaling Pathway |
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | arf6_pathway | Arf6 signaling events |
| pid | ecadherin_keratinocyte_pathway | E-cadherin signaling in keratinocytes |
| pid | ecadherin_stabilization_pathway | Stabilization and expansion of the E-cadherin adherens junction |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | erbb_network_pathway | ErbB receptor signaling network |
| pid | et_egfrpathway | EGFR-dependent Endothelin signaling events |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | shp2_pathway | SHP2 signaling |
| pid | syndecan_3_pathway | Syndecan-3-mediated signaling events |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| pid | telomerasepathway | Regulation of Telomerase |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pid | upa_upar_pathway | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| pharmgkb | PA154426903 | Erlotinib Pathway, Pharmacokinetics |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | Vemurafenib Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | update your name in edit mode |
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | cblpathway | cbl mediated ligand-induced downregulation of egf receptors pathway |
| biocarta | egfpathway | egf signaling pathway |
| biocarta | her2pathway | role of erbb2 in signal transduction and oncology |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | mcalpainpathway | mcalpain and friends in cell motility |
| biocarta | smrtepathway | map kinase inactivation of smrt corepressor |
| biocarta | sprypathway | sprouty regulation of tyrosine kinase signals |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1251932 | PLCG1 events in ERBB2 signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643713 | Signaling by EGFR in Cancer |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-179812 | GRB2 events in EGFR signaling |
| reactome | R-HSA-180292 | GAB1 signalosome |
| reactome | R-HSA-180336 | SHC1 events in EGFR signaling |
| reactome | R-HSA-182971 | EGFR downregulation |
| reactome | R-HSA-1963640 | GRB2 events in ERBB2 signaling |
| reactome | R-HSA-1963642 | PI3K events in ERBB2 signaling |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212718 | EGFR interacts with phospholipase C-gamma |
| reactome | R-HSA-2179392 | EGFR Transactivation by Gastrin |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-445144 | Signal transduction by L1 |
| reactome | R-HSA-5637810 | Constitutive Signaling by EGFRvIII |
| reactome | R-HSA-5637812 | Signaling by EGFRvIII in Cancer |
| reactome | R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| reactome | R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer |
| reactome | R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6785631 | ERBB2 Regulates Cell Motility |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK |
| reactome | R-HSA-8847993 | ERBB2 Activates PTK6 Signaling |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-8857538 | PTK6 promotes HIF1A stabilization |
| reactome | R-HSA-8863795 | Downregulation of ERBB2 signaling |
| reactome | R-HSA-8864260 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
| reactome | R-HSA-8866910 | TFAP2 (AP-2) family regulates transcription of growth factors and their receptors |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD659 | Avagacestat (BMS-708163) | 1 |
| iGMDRD229 | B02 | 1 |
| iGMDRD554 | CHEMBL1434137 | 5 |
| iGMDRD97 | Bexarotene | 1 |
| iGMDRD136 | Nutlin-3 | 1 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD239 | Dasatinib | 1 |
| iGMDRD678 | Tubastatin A | 1 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD201 | SKI II | 4 |
| iGMDRD608 | Refametinib | 1 |
| iGMDRD401 | Afatinib | 206 |
| iGMDRD109 | Gefitinib | 231 |
| iGMDRD613 | CHEMBL258148 | 3 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD870 | BRD63610 | 7 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD782 | DC-45-A2 | 10 |
| iGMDRD573 | GSK-1904529A | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD577 | BIX01294 | 9 |
| iGMDRD312 | Pelitinib | 3 |
| iGMDRD131 | Erlotinib | 199 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD898 | EGFR mAb inhibitor | 2 |
| iGMDRD930 | irreversible EGFR T790M inhibitor | 5 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD232 | FTI-277 | 1 |
| iGMDRD299 | ICL 670 | 4 |
| iGMDRD863 | BRD-K97651142 | 1 |
| iGMDRD912 | first-generation and irreversible EGFR TKIs | 3 |
| iGMDRD492 | HBX-41108 | 1 |
| iGMDRD374 | Zibotentan (ZD4054) | 1 |
| iGMDRD954 | Nimotuzumab | 4 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD959 | novel anti-EGFR mAbs | 2 |
| iGMDRD504 | Obatoclax | 1 |
| iGMDRD389 | SB525334 | 1 |
| iGMDRD62 | Platinum | 1 |
| iGMDRD931 | irreversible EGFR TKIs | 11 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD82 | Quiflapon | 6 |
| iGMDRD894 | EGFR inhibitor | 6 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD472 | PF-562271 | 1 |
| iGMDRD505 | Pevonedistat | 13 |
| iGMDRD721 | HM61713 | 2 |
| iGMDRD895 | EGFR inhibitor 1st gen | 8 |
| iGMDRD1013 | Sym004 | 4 |
| iGMDRD126 | Tipifarnib | 9 |
| iGMDRD899 | EGFR TK inhibitor | 16 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD283 | Bosutinib | 2 |
| iGMDRD417 | XL-647 | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 6 |
| iGMDRD107 | Valdecoxib | 1 |
| iGMDRD675 | Kinome_3629 | 1 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD507 | GSK690693 | 1 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD762 | AZD-9291 | 3 |
| iGMDRD52 | Rotenone | 4 |
| iGMDRD44 | Temozolomide | 1 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD171 | Pemetrexed | 4 |
| iGMDRD117 | Docetaxel | 4 |
| iGMDRD780 | PP-30 | 6 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD399 | Selumetinib | 4 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD41 | Imatinib | 1 |
| iGMDRD896 | EGFR inhibitor 2nd gen | 4 |
| iGMDRD334 | MEK Inhibitor (alone or in combination) | 24 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD369 | TGX-115 | 4 |
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD523 | Cyanoquinoline, 11 | 7 |
| iGMDRD594 | AZD-8055 | 1 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD821 | TAK-788 | 4 |
| iGMDRD184 | IPA-3 | 1 |
| iGMDRD467 | Motesanib | 1 |
| iGMDRD402 | AKT Inhibitor VIII | 1 |
| iGMDRD251 | ML162 | 4 |
| iGMDRD742 | Apicidin | 1 |
| iGMDRD396 | AS601245 | 1 |
| iGMDRD327 | LBH-589 | 1 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD763 | Osimertinib | 16 |
| iGMDRD354 | Midostaurin | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD144 | NSC95397 | 9 |
| iGMDRD797 | ISOX DUAL | 4 |
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD375 | GW-405833 | 13 |
| iGMDRD33 | Entinostat | 1 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD846 | BRD-K24690302 | 1 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD453 | GW2580 | 1 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD447 | Dacomitinib | 21 |
| iGMDRD512 | nutlin 3 | 12 |
| iGMDRD792 | Cetuximab | 76 |
| iGMDRD735 | CO-1686 (AVL-301) | 6 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD160 | Cis-Platin | 1 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD125 | BIRB-796 | 1 |
| iGMDRD627 | BRD-K16147474 | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD765 | BRD-K51490254 | 1 |
| iGMDRD604 | 4449-51-8 | 1 |
| iGMDRD450 | JNJ-26854165 | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD386 | TAK-715 | 1 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD231 | Importazole | 2 |
| iGMDRD333 | MEK Inhibitor | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD6 | AM-580 | 5 |
| iGMDRD1030 | Tyrosine kinase inhibitor | 7 |
| iGMDRD967 | Panitumumab | 13 |
| iGMDRD837 | Bevacizumab | 1 |
| iGMDRD946 | ML320 | 1 |
| iGMDRD42 | Vorinostat | 4 |
| iGMDRD695 | FR-180204 | 2 |
| iGMDRD886 | Compound 1541A | 5 |
| iGMDRD749 | ZINC6718453 | 1 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD866 | BRD1812 | 5 |
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD897 | EGFR inhibitor 3rd gen | 8 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD1001 | Rindopepimut | 2 |
| iGMDRD408 | AEE788 | 1 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD1 | Nicotin-Amide | 1 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD21 | Fluorouracil | 1 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD358 | Semagacestat | 2 |
| iGMDRD159 | 3-Chloro-L-alanine | 1 |
| iGMDRD778 | SCHEMBL13586708 | 1 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD470 | Trametinib | 1 |
| iGMDRD920 | HSP90 inhibitor | 26 |
| iGMDRD816 | anti-EGFR mAbs | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD133 | Lapatinib | 2 |
| iGMDRD356 | PNU-74654 | 6 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD27 | WHI-P97 | 2 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD219 | Bax channel blocker | 1 |
| iGMDRD698 | Neratinib | 1 |
| iGMDRD352 | PD-0325901 | 2 |
| iGMDRD548 | Marinopyrrole A | 1 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD1002 | rTRAIL | 1 |
| iGMDRD240 | Vandetanib | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 7 |
| iGMDRD293 | Bleomycin | 1 |
| iGMDRD121 | GMX1778 | 8 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD103 | SN-38 | 4 |
| iGMDRD672 | Alectinib | 1 |
| iGMDRD372 | TGX 221 | 1 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD16 | CICLOPIROX | 1 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD664 | Dinaciclib | 1 |
| iGMDRD322 | FK 866 | 6 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD147 | Prima-1 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EGFR
CLASSFICATION
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.