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EGFR

Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameepidermal growth factor receptor OMIM IDMIM:131550 Ensembl IDEnsembl:ENSG00000146648 HGNC IDHGNC:HGNC:3236 PHARMGKB IDPA7360 Map Location7p11.2

Gene Categories:

DRUGGABLE GENOME PHOSPHOLIPASE DNA REPAIR SERINE THREONINE KINASE DRUG RESISTANCE TYROSINE KINASE CLINICALLY ACTIONABLE CELL SURFACE TUMOR SUPPRESSOR KINASE

GO terms in EGFR

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IEA	GO:0000139	Golgi membrane
CC	NAS	GO:0005615	extracellular space
CC	IDA	GO:0005634	nucleus
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005768	endosome

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Gene expression in normal tissue: EGFR

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EGFR

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Database	Pathway ID	Pathway Des.
smpdb	SMP00463	Phosphatidylinositol Phosphate Metabolism
smpdb	SMP00472	Erlotinib Action Pathway
smpdb	SMP00473	Gefitinib Action Pathway
smpdb	SMP00474	Cetuximab Action Pathway
smpdb	SMP00475	Panitumumab Action Pathway
smpdb	SMP00476	Trastuzumab Action Pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD772	BRD4770	2
iGMDRD659	Avagacestat (BMS-708163)	1
iGMDRD229	B02	1
iGMDRD554	CHEMBL1434137	5

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EGFR

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.