iGMDRD136


Canonical SMILES: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

InChI: InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)

InChI Key: BDUHCSBCVGXTJM-UHFFFAOYSA-N

Standard NameCHEMBLPubchem CIDDrug StatusDrug Type
Nutlin-3CHEMBL191334 216345AloneSmall Molecule

Drug Targets:

MDM2

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
2956MSH61
3845KRAS1
5295PIK3R11
6597SMARCA41
4771NF21
6598SMARCB11
8242KDM5C1
4851NOTCH11
55294FBXW71
1021CDK61
4610MYCL1
4300MLLT31
51343FZR11
7428VHL1
2064ERBB21
6416MAP2K41
2778GNAS1
1029CDKN2A1
861RUNX11
7157TP531
6794STK111
4292MLH11
1019CDK41
4089SMAD41
3417IDH11
8731RNMT1
5290PIK3CA1
1956EGFR1
4609MYC1
1031CDKN2C1
5156PDGFRA1
673BRAF1
5728PTEN1
208AKT21
3717JAK21
5925RB11
4893NRAS1
7403KDM6A1
595CCND11
4763NF11
4613MYCN1
3265HRAS1
4193MDM21
1499CTNNB11
5624PROC1

Gene in drug-gene network: Network Plot

Models in Nutlin-3

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