Summary: This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008].

AKT serine/threonine kinase 2MIM:164731Ensembl:ENSG00000105221HGNC:HGNC:392PA2468519q13.2

GO terms in AKT2

Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0001934positive regulation of protein phosphorylation
BPIEAGO:0005978glycogen biosynthetic process
BPIEAGO:0006006glucose metabolic process
BPIEAGO:0006417regulation of translation
BPTASGO:0006464cellular protein modification process
BPTASGO:0007165signal transduction
BPIMPGO:0008284positive regulation of cell proliferation
BPIMPGO:0008286insulin receptor signaling pathway
BPTASGO:0008286insulin receptor signaling pathway
BPIEAGO:0008643carbohydrate transport
BPIMPGO:0010748negative regulation of plasma membrane long-chain fatty acid transport
BPIMPGO:0010907positive regulation of glucose metabolic process
BPIMPGO:0010918positive regulation of mitochondrial membrane potential
BPIBAGO:0018105peptidyl-serine phosphorylation
BPTASGO:0030334regulation of cell migration
BPIDAGO:0030335positive regulation of cell migration
BPISSGO:0031340positive regulation of vesicle fusion
BPIMPGO:0032000positive regulation of fatty acid beta-oxidation
BPIEAGO:0032287peripheral nervous system myelin maintenance
BPIMPGO:0032869cellular response to insulin stimulus
BPIBAGO:0035556intracellular signal transduction
BPIMPGO:0043066negative regulation of apoptotic process
BPTASGO:0045444fat cell differentiation
BPIMPGO:0045725positive regulation of glycogen biosynthetic process
BPIMPGO:0046326positive regulation of glucose import
BPTASGO:0060644mammary gland epithelial cell differentiation
BPISSGO:0065002intracellular protein transmembrane transport
BPTASGO:0071156regulation of cell cycle arrest
BPIEAGO:0071486cellular response to high light intensity
BPIEAGO:0072659protein localization to plasma membrane
BPISSGO:0090314positive regulation of protein targeting to membrane
BPIEAGO:0090630activation of GTPase activity
BPIEAGO:0097473retinal rod cell apoptotic process
BPIMPGO:2000147positive regulation of cell motility
BPIEAGO:2001275positive regulation of glucose import in response to insulin stimulus
CCIEAGO:0005769early endosome
CCISSGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCISSGO:0005938cell cortex
CCISSGO:0032587ruffle membrane
CCIDAGO:0032991protein-containing complex
CCIDAGO:0043231intracellular membrane-bounded organelle
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: AKT2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AKT2

DatabasePathway IDPathway Des.
wikipathwaysWP1403AMP-activated Protein Kinase (AMPK) Signaling
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP1559TFs Regulate miRNAs related to cardiac hypertrophy
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2036TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP26Signal Transduction of S1P Receptor
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP306Focal Adhesion
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3965Lipid Metabolism Pathway
wikipathwaysWP4011Steatosis AOP
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP4223Ras Signaling
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP481Insulin Signaling
wikipathwaysWP710DNA Damage Response (only ATM dependent)
wikipathwaysWP75Toll-like Receptor Signaling Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04923Regulation of lipolysis in adipocytes - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa04973Carbohydrate digestion and absorption - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
pidecadherin_keratinocyte_pathwayE-cadherin signaling in keratinocytes
pidinsulin_glucose_pathwayInsulin-mediated glucose transport
pidinsulin_pathwayInsulin Pathway
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidpi3kciaktpathwayClass I PI3K signaling events mediated by Akt
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-109703PKB-mediated events
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-111447Activation of BAD and translocation to mitochondria
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1358803Downregulation of ERBB2:ERBB3 signaling
reactomeR-HSA-1445148Translocation of SLC2A4 (GLUT4) to the plasma membrane
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-165158Activation of AKT2
reactomeR-HSA-165159mTOR signalling
reactomeR-HSA-165160PDE3B signalling
reactomeR-HSA-165181Inhibition of TSC complex formation by PKB
reactomeR-HSA-168256Immune System
reactomeR-HSA-186712Regulation of beta-cell development
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-198323AKT phosphorylates targets in the cytosol
reactomeR-HSA-198323AKT phosphorylates targets in the cytosol
reactomeR-HSA-198693AKT phosphorylates targets in the nucleus
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-210745Regulation of gene expression in beta cells
reactomeR-HSA-211163AKT-mediated inactivation of FOXO1A
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-3769402Deactivation of the beta-catenin transactivating complex
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389356CD28 co-stimulation
reactomeR-HSA-389357CD28 dependent PI3K/Akt signaling
reactomeR-HSA-389513CTLA4 inhibitory signaling
reactomeR-HSA-392451G beta:gamma signalling through PI3Kgamma
reactomeR-HSA-397795G-protein beta:gamma signalling
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-5218920VEGFR2 mediated vascular permeability
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5628897TP53 Regulates Metabolic Genes
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5674400Constitutive Signaling by AKT1 E17K in Cancer
reactomeR-HSA-6804757Regulation of TP53 Degradation
reactomeR-HSA-6804758Regulation of TP53 Activity through Acetylation
reactomeR-HSA-6804759Regulation of TP53 Activity through Association with Co-factors
reactomeR-HSA-6806003Regulation of TP53 Expression and Degradation
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-69202Cyclin E associated events during G1/S transition
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-8863795Downregulation of ERBB2 signaling
reactomeR-HSA-8876198RAB GEFs exchange GTP for GDP on RABs
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8941332RUNX2 regulates genes involved in cell migration
reactomeR-HSA-8948751Regulation of PTEN stability and activity
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9007101Rab regulation of trafficking

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD885Compound 1106
iGMDRD138PX 123
iGMDRD584VER 1550081
iGMDRD512nutlin 33
iGMDRD810allosteric AKT inhibitor1
iGMDRD286Nsc 6328391

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AKT2