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AKT2

Summary: This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameAKT serine/threonine kinase 2 OMIM IDMIM:164731 Ensembl IDEnsembl:ENSG00000105221 HGNC IDHGNC:HGNC:392 PHARMGKB IDPA24685 Map Location19q13.2

Gene Categories:

KINASE TUMOR SUPPRESSOR SERINE THREONINE KINASE CLINICALLY ACTIONABLE DRUGGABLE GENOME

GO terms in AKT2

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	ISS	GO:0001934	positive regulation of protein phosphorylation
BP	IEA	GO:0005978	glycogen biosynthetic process
BP	IEA	GO:0006006	glucose metabolic process
BP	IEA	GO:0006417	regulation of translation
BP	TAS	GO:0006464	cellular protein modification process
BP	TAS	GO:0007165	signal transduction

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Gene expression in normal tissue: AKT2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AKT2

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Database	Pathway ID	Pathway Des.
wikipathways	WP1403	AMP-activated Protein Kinase (AMPK) Signaling
wikipathways	WP1449	Regulation of toll-like receptor signaling pathway
wikipathways	WP1544	MicroRNAs in cardiomyocyte hypertrophy
wikipathways	WP1559	TFs Regulate miRNAs related to cardiac hypertrophy
wikipathways	WP185	Integrin-mediated Cell Adhesion
wikipathways	WP2018	RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD144	NSC95397	3
iGMDRD1008	SR-II-138A	3
iGMDRD136	Nutlin-3	1
iGMDRD126	Tipifarnib	4

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AKT2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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