JAK2


Summary: This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Janus kinase 2MIM:147796Ensembl:ENSG00000096968HGNC:HGNC:6192PA299899p24.1

GO terms in JAK2


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIEAGO:0005856cytoskeleton
CCIDAGO:0005886plasma membrane
CCISSGO:0005901caveola
CCIDAGO:0005925focal adhesion
CCIEAGO:0016363nuclear matrix
CCTASGO:0031904endosome lumen
CCISSGO:0045121membrane raft
BPTASGO:0000165MAPK cascade
BPIEAGO:0000186activation of MAPKK activity
BPIEAGO:0002250adaptive immune response
BPTASGO:0006468protein phosphorylation
BPISSGO:0006915apoptotic process
BPISSGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPISSGO:0007165signal transduction
BPISSGO:0007167enzyme linked receptor protein signaling pathway
BPIEAGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0007204positive regulation of cytosolic calcium ion concentration
BPTASGO:0007259JAK-STAT cascade
BPIBAGO:0007260tyrosine phosphorylation of STAT protein
BPISSGO:0007260tyrosine phosphorylation of STAT protein
BPTASGO:0007498mesoderm development
BPTASGO:0007596blood coagulation
BPISSGO:0008285negative regulation of cell proliferation
BPIEAGO:0008631intrinsic apoptotic signaling pathway in response to oxidative stress
BPIEAGO:0010667negative regulation of cardiac muscle cell apoptotic process
BPIDAGO:0010811positive regulation of cell-substrate adhesion
BPISSGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPISSGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0019221cytokine-mediated signaling pathway
BPIDAGO:0019221cytokine-mediated signaling pathway
BPISSGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0022408negative regulation of cell-cell adhesion
BPNASGO:0030041actin filament polymerization
BPISSGO:0030154cell differentiation
BPIBAGO:0030155regulation of cell adhesion
BPIBAGO:0030218erythrocyte differentiation
BPISSGO:0030218erythrocyte differentiation
BPIEAGO:0030335positive regulation of cell migration
BPIEAGO:0031103axon regeneration
BPIEAGO:0031959mineralocorticoid receptor signaling pathway
BPIEAGO:0032024positive regulation of insulin secretion
BPISSGO:0032496response to lipopolysaccharide
BPIEAGO:0032516positive regulation of phosphoprotein phosphatase activity
BPIEAGO:0032731positive regulation of interleukin-1 beta production
BPISSGO:0032760positive regulation of tumor necrosis factor production
BPIEAGO:0033160positive regulation of protein import into nucleus, translocation
BPIEAGO:0033194response to hydroperoxide
BPIDAGO:0033209tumor necrosis factor-mediated signaling pathway
BPIDAGO:0034612response to tumor necrosis factor
BPIBAGO:0035409histone H3-Y41 phosphorylation
BPIDAGO:0035409histone H3-Y41 phosphorylation
BPISSGO:0035556intracellular signal transduction
BPIDAGO:0035722interleukin-12-mediated signaling pathway
BPTASGO:0035722interleukin-12-mediated signaling pathway
BPTASGO:0038155interleukin-23-mediated signaling pathway
BPISSGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPISSGO:0042976activation of Janus kinase activity
BPIBAGO:0042981regulation of apoptotic process
BPIEAGO:0043388positive regulation of DNA binding
BPISSGO:0043392negative regulation of DNA binding
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPIEAGO:0045429positive regulation of nitric oxide biosynthetic process
BPIEAGO:0045597positive regulation of cell differentiation
BPIEAGO:0045822negative regulation of heart contraction
BPISSGO:0046425regulation of JAK-STAT cascade
BPIDAGO:0046677response to antibiotic
BPISSGO:0046777protein autophosphorylation
BPIEAGO:0048008platelet-derived growth factor receptor signaling pathway
BPIDAGO:0050727regulation of inflammatory response
BPIEAGO:0050729positive regulation of inflammatory response
BPISSGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIEAGO:0050867positive regulation of cell activation
BPIEAGO:0051091positive regulation of DNA-binding transcription factor activity
BPISSGO:0051770positive regulation of nitric-oxide synthase biosynthetic process
BPTASGO:0060333interferon-gamma-mediated signaling pathway
BPTASGO:0060334regulation of interferon-gamma-mediated signaling pathway
BPIDAGO:0060396growth hormone receptor signaling pathway
BPISSGO:0060397JAK-STAT cascade involved in growth hormone signaling pathway
BPTASGO:0060397JAK-STAT cascade involved in growth hormone signaling pathway
BPISSGO:0060399positive regulation of growth hormone receptor signaling pathway
BPISSGO:0061180mammary gland epithelium development
BPTASGO:0070102interleukin-6-mediated signaling pathway
BPTASGO:0070106interleukin-27-mediated signaling pathway
BPIDAGO:0070671response to interleukin-12
BPTASGO:0070757interleukin-35-mediated signaling pathway
BPISSGO:0097191extrinsic apoptotic signaling pathway
BPISSGO:0097296activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
BPIEAGO:1902728positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
BPIEAGO:1904037positive regulation of epithelial cell apoptotic process
BPIEAGO:1904707positive regulation of vascular smooth muscle cell proliferation
MFTASGO:0004672protein kinase activity
MFEXPGO:0004713protein tyrosine kinase activity
MFIDAGO:0004713protein tyrosine kinase activity
MFISSGO:0004713protein tyrosine kinase activity
MFTASGO:0004713protein tyrosine kinase activity
MFTASGO:0004715non-membrane spanning protein tyrosine kinase activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIPIGO:0005102signaling receptor binding
MFIBAGO:0005131growth hormone receptor binding
MFISSGO:0005131growth hormone receptor binding
MFISSGO:0005143interleukin-12 receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0008022protein C-terminus binding
MFIDAGO:0019901protein kinase binding
MFIDAGO:0020037heme binding
MFIEAGO:0031702type 1 angiotensin receptor binding
MFIEAGO:0033130acetylcholine receptor binding
MFIBAGO:0035401histone kinase activity (H3-Y41 specific)
MFIDAGO:0035401histone kinase activity (H3-Y41 specific)
MFIPIGO:0042169SH2 domain binding
MFIDAGO:0042393histone binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0043548phosphatidylinositol 3-kinase binding
MFIEAGO:0043560insulin receptor substrate binding
MFIEAGO:0046872metal ion binding
MFIEAGO:0051428peptide hormone receptor binding

Gene expression in normal tissue: JAK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in JAK2


DatabasePathway IDPathway Des.
reactomeR-HSA-1059683Interleukin-6 signaling
reactomeR-HSA-1059683Interleukin-6 signaling
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-110056MAPK3 (ERK1) activation
reactomeR-HSA-112409RAF-independent MAPK1/3 activation
reactomeR-HSA-112411MAPK1 (ERK2) activation
reactomeR-HSA-1170546Prolactin receptor signaling
reactomeR-HSA-1170546Prolactin receptor signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1643685Disease
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-2586552Signaling by Leptin
reactomeR-HSA-3214858RMTs methylate histone arginines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-447115Interleukin-12 family signaling
reactomeR-HSA-447115Interleukin-12 family signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673000RAF activation
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6783589Interleukin-6 family signaling
reactomeR-HSA-6783589Interleukin-6 family signaling
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-6788467IL-6-type cytokine receptor ligand interactions
reactomeR-HSA-6802946Signaling by moderate kinase activity BRAF mutants
reactomeR-HSA-6802949Signaling by RAS mutants
reactomeR-HSA-6802952Signaling by BRAF and RAF fusions
reactomeR-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAF
reactomeR-HSA-6802957Oncogenic MAPK signaling
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-877300Interferon gamma signaling
reactomeR-HSA-877312Regulation of IFNG signaling
reactomeR-HSA-877312Regulation of IFNG signaling
reactomeR-HSA-8854691Interleukin-20 family signaling
reactomeR-HSA-8984722Interleukin-35 Signalling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9020591Interleukin-12 signaling
reactomeR-HSA-9020591Interleukin-12 signaling
reactomeR-HSA-9020933Interleukin-23 signaling
reactomeR-HSA-9020933Interleukin-23 signaling
reactomeR-HSA-9020956Interleukin-27 signaling
reactomeR-HSA-9020956Interleukin-27 signaling
reactomeR-HSA-912526Interleukin receptor SHC signaling
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-913531Interferon Signaling
reactomeR-HSA-982772Growth hormone receptor signaling
reactomeR-HSA-982772Growth hormone receptor signaling
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production
biocartabiopeptidespathwaybioactive peptide induced signaling pathway
biocartaeponfkbpathwayerythropoietin mediated neuroprotection through nf-kb
biocartaepopathwayepo signaling pathway
biocartaghpathwaygrowth hormone signaling pathway
biocartagleevecpathwayinhibition of cellular proliferation by gleevec
biocartaher2pathwayrole of erbb2 in signal transduction and oncology
biocartaifngpathwayifn gamma signaling pathway
biocartail12pathwayil12 and stat4 dependent signaling pathway in th1 development
biocartail3pathwayil 3 signaling pathway
biocartail6pathwayil 6 signaling pathway
biocartano2il12pathwayno2-dependent il-12 pathway in nk cells
biocartastat3pathwaystat3 signaling pathway
biocartatidpathwaychaperones modulate interferon signaling pathway
biocartatpopathwaytpo signaling pathway
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
pidcxcr4_pathwayCXCR4-mediated signaling events
pidendothelinpathwayEndothelins
pidepopathwayEPO signaling pathway
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
piderbb4_pathwayErbB4 signaling events
pidgmcsf_pathwayGMCSF-mediated signaling events
pidhes_heypathwayNotch-mediated HES/HEY network
pidifngpathwayIFN-gamma pathway
pidil12_2pathwayIL12-mediated signaling events
pidil23pathwayIL23-mediated signaling events
pidil27pathwayIL27-mediated signaling events
pidil3_pathwayIL3-mediated signaling events
pidil4_2pathwayIL4-mediated signaling events
pidil5_pathwayIL5-mediated signaling events
pidil6_7pathwayIL6-mediated signaling events
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidptp1bpathwaySignaling events mediated by PTP1B
pids1p_s1p3_pathwayS1P3 pathway
pidshp2_pathwaySHP2 signaling
netpathPathway_EGFR1EGFR1
netpathPathway_GastrinGastrin
netpathPathway_IL11IL11
netpathPathway_IL3IL3
netpathPathway_IL4IL4
netpathPathway_IL5IL5
netpathPathway_IL6IL6
netpathPathway_KitReceptorKitReceptor
netpathPathway_LeptinLeptin
netpathPathway_NotchNotch
netpathPathway_Oncostatin_MOncostatin_M
netpathPathway_ProlactinProlactin
netpathPathway_TSLPTSLP
wikipathwaysWP127IL-5 Signaling Pathway
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2112IL17 signaling pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2512Integrated Lung Cancer Pathway
wikipathwaysWP2593JAK-STAT
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP364IL-6 signaling pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3935Leptin Insulin Overlap
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4197The human immune response to tuberculosis
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP581EPO Receptor Signaling
wikipathwaysWP61Notch Signaling Pathway
wikipathwaysWP619Type II interferon signaling (IFNG)
wikipathwaysWP733Serotonin Receptor 2 and STAT3 Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD435BI-25363
iGMDRD132(-)-gallocatechin-3-O-gallate1
iGMDRD933JAK inhibitor (alone or in combination)2
iGMDRD676Birinapant1
iGMDRD536PLX-47201
iGMDRD701NVP-AUY9223
iGMDRD720844499-71-41
iGMDRD307Manumycin A2
iGMDRD84Lovastatin acid2
iGMDRD382CEP-7011
iGMDRD684Spautin-11
iGMDRD505Pevonedistat3
iGMDRD882CIL412
iGMDRD872BRD71372
iGMDRD414MST-3129
iGMDRD481Dactolisib1
iGMDRD434BMS-5369241
iGMDRD6AM-5803
iGMDRD280CYTOCHALASIN B5
iGMDRD401Afatinib1
iGMDRD193Fqi13
iGMDRD797ISOX DUAL3
iGMDRD253Vincaleukoblastine1
iGMDRD542Erismodegib1
iGMDRD1008SR-II-138A3
iGMDRD772BRD47702
iGMDRD599Salermide3
iGMDRD229B021
iGMDRD136Nutlin-31
iGMDRD268Cerulenin2
iGMDRD60Quinoclamine3
iGMDRD690PRIMA-1MET2
iGMDRD395LY21572991
iGMDRD887Compound 23 citrate2
iGMDRD30917AAG1
iGMDRD574Ruxolitinib4
iGMDRD870BRD636103
iGMDRD318PAC-13
iGMDRD885Compound 1101
iGMDRD138PX 123
iGMDRD154NSC237661
iGMDRD883CIL55A1
iGMDRD945ML2143
iGMDRD123Isoevodiamine3
iGMDRD698Neratinib3
iGMDRD352PD-03259011
iGMDRD341Triacsin c4
iGMDRD150RITA2
iGMDRD560MK-22063
iGMDRD584VER 1550081
iGMDRD147Prima-12
iGMDRD932JAK inhibitor2
iGMDRD367Ro 28-16753
iGMDRD286Nsc 6328395
iGMDRD871BRD63684
iGMDRD705Nakiterpiosin8
iGMDRD289Parthenolide3
iGMDRD975PD-1 Inhibitor1
iGMDRD5Tyrphostin AG 14783
iGMDRD251ML1623
iGMDRD202Curcumin2
iGMDRD103SN-383
iGMDRD639YK 4-2793
iGMDRD484Pluripotin6
iGMDRD974PD1 blockade1
iGMDRD781Sirolimus4
iGMDRD425ERASTIN2
iGMDRD433Lexibulin3
iGMDRD151CHM-13
iGMDRD524ISX-93
iGMDRD978Pembrolizumab1
iGMDRD190Nilotinib1
iGMDRD64Parbendazole3
iGMDRD780PP-302
iGMDRD506Fedratinib1
iGMDRD399Selumetinib1
iGMDRD516Z-LLNle-CHO1
iGMDRD187BRD98762
iGMDRD284Palbociclib1
iGMDRD260FQI-23

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in JAK2

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