JAK2

Summary: This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameJanus kinase 2
OMIM IDMIM:147796
Ensembl IDEnsembl:ENSG00000096968
HGNC IDHGNC:HGNC:6192
PHARMGKB IDPA29989
Map Location9p24.1

GO terms in JAK2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005634 nucleus
CC IDA GO:0005654 nucleoplasm
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0005737 cytoplasm
CC TAS GO:0005829 cytosol
CC IEA GO:0005856 cytoskeleton
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Gene expression in normal tissue: JAK2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 13undefinedtissue: undefined cancer: PANCAN model num: 136LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 19OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 5BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 3BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 2BLOODtissue: BLOOD cancer: Acute Myeloid Leukemia (AML) model num: 3BLOODtissue: BLOOD cancer: Myelofibrosis/Osteomyelofibrosis (MYF) model num: 1BLOODtissue: BLOOD cancer: Acute Lymphoid Leukemia (ALL) model num: 2BLOODtissue: BLOOD cancer: Polycythemia Vera (PCV) model num: 1BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Invasive Breast Carcinoma (BRCA) model num: 1BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 1SKINtissue: SKIN cancer: Melanoma (MEL) model num: 2

Gene-drug pathway distribution

undefined59ERK MAPK signaling3Other, kinases3Cell cycle2Protein stability and degradation2PI3K/MTOR signaling2Longevity regulating pathway1Ferroptosis1ABL signaling1DNA replication1

Pathways in JAK2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1059683 Interleukin-6 signaling
reactome R-HSA-1059683 Interleukin-6 signaling
reactome R-HSA-109582 Hemostasis
reactome R-HSA-110056 MAPK3 (ERK1) activation
reactome R-HSA-112409 RAF-independent MAPK1/3 activation
reactome R-HSA-112411 MAPK1 (ERK2) activation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD435 BI-2536 3
iGMDRD132 (-)-gallocatechin-3-O-gallate 1
iGMDRD933 JAK inhibitor (alone or in combination) 2
iGMDRD676 Birinapant 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in JAK2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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