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iGMDRD401

Canonical SMILES: CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4

InChI: InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1

InChI Key: ULXXDDBFHOBEHA-CWDCEQMOSA-N

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Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Standard NameAfatinib CHEMBLCHEMBL2105712 CHEMBL1173655 Pubchem CID10184700 DRUGBANK IDDB08916 Drug StatusAlone Drug TypeSmall Molecule

Drug Class:

Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors BCRP/ABCG2 Substrates Heterocyclic Compounds Heterocyclic Compounds, 2-Ring Kinase Inhibitor P-glycoprotein/ABCB1 Inhibitors P-glycoprotein/ABCB1 Substrates Protein Kinase Inhibitors

Drug Targets:

EGFR (P00533)ERBB2 (P04626)ERBB4 (Q15303)

Drug Pathways:

EGFR signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

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Gene ID	Gene Name	Model Num.
7514	XPO1	1
3845	KRAS	5
8289	ARID1A	2
4771	NF2	3

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Gene in drug-gene network: Network Plot

Models in Afatinib

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.