Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008].

mitogen-activated protein kinase kinase 2MIM:601263Ensembl:ENSG00000126934HGNC:HGNC:6842PA3058719p13.3

GO terms in MAP2K2

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004708MAP kinase kinase activity
MFIDAGO:0004708MAP kinase kinase activity
MFTASGO:0004712protein serine/threonine/tyrosine kinase activity
MFIEAGO:0004713protein tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0030165PDZ domain binding
MFIDAGO:0043539protein serine/threonine kinase activator activity
MFIEAGO:0046872metal ion binding
MFIPIGO:0097110scaffold protein binding
BPTASGO:0000165MAPK cascade
BPIBAGO:0000187activation of MAPK activity
BPTASGO:0000187activation of MAPK activity
BPIBAGO:0007346regulation of mitotic cell cycle
BPIGIGO:0010629negative regulation of gene expression
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIBAGO:0032147activation of protein kinase activity
BPTASGO:0032872regulation of stress-activated MAPK cascade
BPIDAGO:0036289peptidyl-serine autophosphorylation
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0070371ERK1 and ERK2 cascade
BPTASGO:0070371ERK1 and ERK2 cascade
BPIDAGO:0071902positive regulation of protein serine/threonine kinase activity
BPTASGO:0090170regulation of Golgi inheritance
BPIMPGO:1903800positive regulation of production of miRNAs involved in gene silencing by miRNA
BPTASGO:2000641regulation of early endosome to late endosome transport
CCNASGO:0005576extracellular region
CCTASGO:0005769early endosome
CCTASGO:0005770late endosome
CCHDAGO:0005778peroxisomal membrane
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0005794Golgi apparatus
CCTASGO:0005794Golgi apparatus
CCIDAGO:0005911cell-cell junction
CCTASGO:0005925focal adhesion
CCIDAGO:0009898cytoplasmic side of plasma membrane
CCIDAGO:0048471perinuclear region of cytoplasm

Gene expression in normal tissue: MAP2K2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP2K2

DatabasePathway IDPathway Des.
biocartaanthraxpathwayanthrax toxin mechanism of action
biocartaat1rpathwayangiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
biocartabarrestinsrcpathwayroles of arrestin dependent recruitment of src kinases in gpcr signaling
biocartabarrmapkpathwayrole of -arrestins in the activation and targeting of map kinases
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocartacdk5pathwayphosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway
biocartacdmacpathwaycadmium induces dna synthesis and proliferation in macrophages
biocartaceramidepathwayceramide signaling pathway
biocartaedg1pathwayphospholipids as signalling intermediaries
biocartaerk5pathwayrole of erk5 in neuronal survival pathway
biocartaerkpathwayerk1/erk2 mapk signaling pathway
biocartafcer1pathwayfc epsilon receptor i signaling in mast cells
biocartafmlppathwayfmlp induced chemokine gene expression in hmc-1 cells
biocartahcmvpathwayhuman cytomegalovirus and map kinase pathways
biocartaher2pathwayrole of erbb2 in signal transduction and oncology
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamalpathwayrole of mal in rho-mediated activation of srf
biocartamapkpathwaymapkinase signaling pathway
biocartamcalpainpathwaymcalpain and friends in cell motility
biocartamelanocytepathwaymelanocyte development and pigmentation pathway
biocartapyk2pathwaylinks between pyk2 and map kinases
biocartaraccycdpathwayinfluence of ras and rho proteins on g1 to s transition
biocartasam68pathwayregulation of splicing through sam68
biocartasprypathwaysprouty regulation of tyrosine kinase signals
biocartatffpathwaytrefoil factors initiate mucosal healing
reactomeR-HSA-112409RAF-independent MAPK1/3 activation
reactomeR-HSA-112411MAPK1 (ERK2) activation
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445144Signal transduction by L1
reactomeR-HSA-5210891Uptake and function of anthrax toxins
reactomeR-HSA-5339562Uptake and actions of bacterial toxins
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5673000RAF activation
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5674135MAP2K and MAPK activation
reactomeR-HSA-5674499Negative feedback regulation of MAPK pathway
reactomeR-HSA-5675221Negative regulation of MAPK pathway
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6802946Signaling by moderate kinase activity BRAF mutants
reactomeR-HSA-6802948Signaling by high-kinase activity BRAF mutants
reactomeR-HSA-6802949Signaling by RAS mutants
reactomeR-HSA-6802952Signaling by BRAF and RAF fusions
reactomeR-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAF
reactomeR-HSA-6802957Oncogenic MAPK signaling
humancycPWY66-14MAP kinase cascade
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05020Prion diseases - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
wikipathwaysWP127IL-5 Signaling Pathway
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP205IL-7 Signaling Pathway
wikipathwaysWP22IL-9 Signaling Pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2447Amyotrophic lateral sclerosis (ALS)
wikipathwaysWP2636Common Pathways Underlying Drug Addiction
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP313Signaling of Hepatocyte Growth Factor Receptor
wikipathwaysWP364IL-6 signaling pathway
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP38794-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP422MAPK Cascade
wikipathwaysWP4223Ras Signaling
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP49IL-2 Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP581EPO Receptor Signaling
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP722Serotonin HTR1 Group and FOS Pathway
wikipathwaysWP732Serotonin Receptor 2 and ELK-SRF-GATA4 signaling
wikipathwaysWP734Serotonin Receptor 4-6-7 and NR3C Signaling
wikipathwaysWP75Toll-like Receptor Signaling Pathway
smpdbSMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdbSMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells
smpdbSMP00391Insulin Signalling
pidanthraxpathwayCellular roles of Anthrax toxin
pidar_nongenomic_pathwayNongenotropic Androgen signaling
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidceramide_pathwayCeramide signaling pathway
pidcxcr3pathwayCXCR3-mediated signaling events
piderbb1_downstream_pathwayErbB1 downstream signaling
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidgmcsf_pathwayGMCSF-mediated signaling events
pidil2_1pathwayIL2-mediated signaling events
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidmtor_4pathwaymTOR signaling pathway
pidnetrin_pathwayNetrin-mediated signaling events
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidshp2_pathwaySHP2 signaling
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pharmgkbPA165959584Sorafenib Pharmacodynamics
pharmgkbPA165980050Vemurafenib Pathway, Pharmacodynamics
pharmgkbPA165980050update your name in edit mode
pharmgkbPA2032VEGF Signaling Pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD885Compound 1103
iGMDRD514ERK inhibitor5
iGMDRD333MEK Inhibitor10
iGMDRD839BRAF inhibitor10
iGMDRD367Ro 28-16753
iGMDRD286Nsc 6328393

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP2K2