PTK2
Summary: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein tyrosine kinase 2 | MIM:600758 | Ensembl:ENSG00000169398 | HGNC:HGNC:9611 | PA33955 | 8q24.3 |
GO terms in PTK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0001725 | stress fiber |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005856 | cytoskeleton |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0005938 | cell cortex |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0030027 | lamellipodium |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IBA | GO:0043197 | dendritic spine |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000226 | microtubule cytoskeleton organization |
| BP | IBA | GO:0001525 | angiogenesis |
| BP | TAS | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001570 | vasculogenesis |
| BP | IEA | GO:0001764 | neuron migration |
| BP | TAS | GO:0001890 | placenta development |
| BP | IGI | GO:0001932 | regulation of protein phosphorylation |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | TAS | GO:0003007 | heart morphogenesis |
| BP | IEA | GO:0007097 | nuclear migration |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IEA | GO:0007172 | signal complex assembly |
| BP | IBA | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | IDA | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IDA | GO:0007229 | integrin-mediated signaling pathway |
| BP | IMP | GO:0007229 | integrin-mediated signaling pathway |
| BP | TAS | GO:0007229 | integrin-mediated signaling pathway |
| BP | TAS | GO:0007411 | axon guidance |
| BP | ISS | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008360 | regulation of cell shape |
| BP | IEA | GO:0010507 | negative regulation of autophagy |
| BP | TAS | GO:0010594 | regulation of endothelial cell migration |
| BP | IEA | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| BP | IGI | GO:0010632 | regulation of epithelial cell migration |
| BP | IMP | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0021955 | central nervous system neuron axonogenesis |
| BP | IDA | GO:0022408 | negative regulation of cell-cell adhesion |
| BP | TAS | GO:0030010 | establishment of cell polarity |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0030155 | regulation of cell adhesion |
| BP | IEA | GO:0030198 | extracellular matrix organization |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IDA | GO:0033628 | regulation of cell adhesion mediated by integrin |
| BP | TAS | GO:0038007 | netrin-activated signaling pathway |
| BP | IBA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | IMP | GO:0042127 | regulation of cell proliferation |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043087 | regulation of GTPase activity |
| BP | IEA | GO:0043542 | endothelial cell migration |
| BP | TAS | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IMP | GO:0045667 | regulation of osteoblast differentiation |
| BP | IMP | GO:0045860 | positive regulation of protein kinase activity |
| BP | IEA | GO:0046621 | negative regulation of organ growth |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IDA | GO:0048013 | ephrin receptor signaling pathway |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | TAS | GO:0048870 | cell motility |
| BP | IEA | GO:0050771 | negative regulation of axonogenesis |
| BP | TAS | GO:0051493 | regulation of cytoskeleton organization |
| BP | IGI | GO:0051893 | regulation of focal adhesion assembly |
| BP | TAS | GO:0051893 | regulation of focal adhesion assembly |
| BP | IMP | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0051964 | negative regulation of synapse assembly |
| BP | IDA | GO:0060396 | growth hormone receptor signaling pathway |
| BP | IGI | GO:1900024 | regulation of substrate adhesion-dependent cell spreading |
| BP | ISS | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:2000811 | negative regulation of anoikis |
| MF | IDA | GO:0003779 | actin binding |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IDA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0008432 | JUN kinase binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0042169 | SH2 domain binding |
Gene expression in normal tissue: PTK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-111465 | Apoptotic cleavage of cellular proteins |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-354192 | Integrin alphaIIb beta3 signaling |
| reactome | R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins |
| reactome | R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-391160 | Signal regulatory protein family interactions |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-418885 | DCC mediated attractive signaling |
| reactome | R-HSA-418885 | DCC mediated attractive signaling |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5663213 | RHO GTPases Activate WASPs and WAVEs |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-75153 | Apoptotic execution phase |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76009 | Platelet Aggregation (Plug Formation) |
| reactome | R-HSA-8874081 | MET activates PTK2 signaling |
| reactome | R-HSA-8875878 | MET promotes cell motility |
| reactome | R-HSA-9006921 | Integrin signaling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| biocarta | achpathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis |
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| biocarta | ccr3pathway | ccr3 signaling in eosinophils |
| biocarta | cell2cellpathway | cell to cell adhesion signaling |
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | integrinpathway | integrin signaling pathway |
| biocarta | mcalpainpathway | mcalpain and friends in cell motility |
| biocarta | ptenpathway | pten dependent cell cycle arrest and apoptosis |
| biocarta | ucalpainpathway | ucalpain and friends in cell spread |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| pid | a4b7_pathway | a4b7 Integrin signaling |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | epha2_fwdpathway | EPHA2 forward signaling |
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | igf1_pathway | IGF1 pathway |
| pid | integrin_a4b1_pathway | Alpha4 beta1 integrin signaling events |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | nectin_pathway | Nectin adhesion pathway |
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_CRH | CRH |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_RANKL | RANKL |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| netpath | Pathway_TNFalpha | TNFalpha |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP244 | Alpha 6 Beta 4 signaling pathway |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP313 | Signaling of Hepatocyte Growth Factor Receptor |
| wikipathways | WP3287 | Overview of nanoparticle effects |
| wikipathways | WP3301 | MFAP5-mediated ovarian cancer cell motility and invasiveness |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3995 | Prion disease pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP673 | ErbB Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD97 | Bexarotene | 1 |
| iGMDRD401 | Afatinib | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD41 | Imatinib | 1 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD185 | DMOG | 1 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD215 | CCT007093 | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD329 | Merck60 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTK2
CLASSFICATION
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