iGMDRD41
Canonical SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
InChI: InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
InChI Key: KTUFNOKKBVMGRW-UHFFFAOYSA-N
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Standard Name | CHEMBL | Pubchem CID | KEGG Drug ID | DRUGBANK ID | Drug Status | Drug targets (TTD) | Drug Type |
|---|---|---|---|---|---|---|---|
Standard NameImatinib CHEMBLCHEMBL2386595 CHEMBL1642 CHEMBL941 Pubchem CID5291 KEGG Drug IDD08066 DRUGBANK IDDB00619 Drug StatusAlone Drug targets (TTD)DNC001383 Drug TypeSmall Molecule | |||||||
Drug Class:
Acids, CarbocyclicAmidesAntineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 InhibitorsBCRP/ABCG2 SubstratesBenzamides and benzamide derivativesBenzene DerivativesBenzoatesCarboxylic AcidsCardiotoxic antineoplastic agentsCombined Inhibitors of CYP3A4 and P-glycoproteinCombined Inhibitors of CYP3A4 and P-glycoprotein (Moderate)Cytochrome P-450 CYP1A2 SubstratesCytochrome P-450 CYP2D6 InhibitorsCytochrome P-450 CYP2D6 Inhibitors (weak)Cytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 InhibitorsCytochrome P-450 CYP3A4 Inhibitors (moderate)Cytochrome P-450 CYP3A4 SubstratesCytochrome P-450 CYP3A5 SubstratesCytochrome P-450 CYP3A7 SubstratesCytochrome P-450 Enzyme InhibitorsEnzyme InhibitorsHeterocyclic CompoundsHeterocyclic Compounds, 1-RingHydrocarbonsHydrocarbons, AromaticHydrocarbons, CyclicImmunosuppressive AgentsKinase InhibitorMiscellaneous Therapeutic AgentsMyelosuppressive AgentsP-glycoprotein/ABCB1 InhibitorsP-glycoprotein/ABCB1 SubstratesPiperazinesProtein Kinase InhibitorsPyrimidinesTyrosine Kinase InhibitorsDrug Targets:
BCR/ABL fusion (A9UF02)KIT (P10721)RET (O43519)NTRK1 (P04629)CSF1R (P07333)PDGFRA (P16234)DDR1 (Q08345)ABL1 (P00519)PDGFRB (P09619)Drug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
Gene in drug-gene network: Network Plot
Models in Imatinib
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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