LCK

Summary: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameLCK proto-oncogene, Src family tyrosine kinase
OMIM IDMIM:153390
Ensembl IDEnsembl:ENSG00000182866
HGNC IDHGNC:HGNC:6524
PHARMGKB IDPA30307
Map Location1p35.2

GO terms in LCK


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0001784 phosphotyrosine residue binding
MF EXP GO:0004713 protein tyrosine kinase activity
MF IDA GO:0004713 protein tyrosine kinase activity
MF IMP GO:0004713 protein tyrosine kinase activity
MF ISS GO:0004713 protein tyrosine kinase activity
MF TAS GO:0004713 protein tyrosine kinase activity
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Gene expression in normal tissue: LCK

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 106BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 10UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 2SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: undefined model num: 2BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 1LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 2BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 1

Gene-drug pathway distribution

undefined37RTK signaling8Cell cycle5JNK and p38 signaling3Cytoskeleton3PI3K/MTOR signaling2Genome integrity2Chromatin histone acetylation2DNA replication2Protein stability and degradation2

Pathways in LCK


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-114604 GPVI-mediated activation cascade
reactome R-HSA-1257604 PIP3 activates AKT signaling
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-1433557 Signaling by SCF-KIT
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD239 Dasatinib 1
iGMDRD587 CHEMBL585951 1
iGMDRD112 Methotrexate 1
iGMDRD659 Avagacestat (BMS-708163) 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LCK

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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