iGMDRD239
Canonical SMILES: CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C
InChI: InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
InChI Key: ZBNZXTGUTAYRHI-UHFFFAOYSA-N
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Standard Name | CHEMBL | Pubchem CID | KEGG Drug ID | DRUGBANK ID | Drug Status | Drug targets (TTD) | Drug Type |
---|---|---|---|---|---|---|---|
Standard NameDasatinib CHEMBLCHEMBL1421 Pubchem CID3062320 KEGG Drug IDD03658 DRUGBANK IDDB01254 Drug StatusAlone Drug targets (TTD)DAP000004 Drug TypeSmall Molecule |
Drug Class:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsAzolesBCRP/ABCG2 InhibitorsBCRP/ABCG2 SubstratesCYP3A Substrates (Sensitive)Cytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 InhibitorsCytochrome P-450 CYP3A4 Inhibitors (weak)Cytochrome P-450 Enzyme InhibitorsEnzyme InhibitorsHeterocyclic CompoundsHeterocyclic Compounds, 1-RingImmunosuppressive AgentsKinase InhibitorMyelosuppressive AgentsP-glycoprotein/ABCB1 InhibitorsP-glycoprotein/ABCB1 SubstratesPotential QTc-Prolonging AgentsProtein Kinase InhibitorsPyrimidinesQTc Prolonging AgentsSulfur CompoundsThiazolesDrug Targets:
ABL1 (P00519)SRC (P12931)EPHA2 (P29317)LCK (P06239)YES1 (P07947)KIT (P10721)PDGFRB (P09619)STAT5B (P51692)ABL2 (P42684)FYN (P06241)BTK (Q06187)NR4A3 (Q92570)BCR (P11274)CSK (P41240)EPHA5 (P54756)EPHB4 (P54760)FGR (P09769)FRK (P42685)HSPA8 (P11142)LYN (P07948)ZAK (Q9NYL2)MAPK14 (Q16539)PPAT (Q06203)Drug Pathways:
MAPK signaling pathwayErbB signaling pathwayVEGF signaling pathwayPathways in cancerChronic myeloid leukemiaDrug Synonyms:
Dasatinib (JAN/INN)Drug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
Gene in drug-gene network: Network Plot

Models in Dasatinib
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |