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iGMDRD239

Canonical SMILES: CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C

InChI: InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)

InChI Key: ZBNZXTGUTAYRHI-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Dasatinib	CHEMBL1421	3062320	D03658	DB01254	Alone	DAP000004	Small Molecule

Drug Class:

Antineoplastic Agents Antineoplastic and Immunomodulating Agents Azoles BCRP/ABCG2 Inhibitors BCRP/ABCG2 Substrates CYP3A Substrates (Sensitive)Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak)Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Immunosuppressive Agents Kinase Inhibitor Myelosuppressive Agents P-glycoprotein/ABCB1 Inhibitors P-glycoprotein/ABCB1 Substrates Potential QTc-Prolonging Agents Protein Kinase Inhibitors Pyrimidines QTc Prolonging Agents Sulfur Compounds Thiazoles

Drug Targets:

ABL1 (P00519)SRC (P12931)EPHA2 (P29317)LCK (P06239)YES1 (P07947)KIT (P10721)PDGFRB (P09619)STAT5B (P51692)ABL2 (P42684)FYN (P06241)BTK (Q06187)NR4A3 (Q92570)BCR (P11274)CSK (P41240)EPHA5 (P54756)EPHB4 (P54760)FGR (P09769)FRK (P42685)HSPA8 (P11142)LYN (P07948)ZAK (Q9NYL2)MAPK14 (Q16539)PPAT (Q06203)

Drug Pathways:

MAPK signaling pathway ErbB signaling pathway VEGF signaling pathway Pathways in cancer Chronic myeloid leukemia

Drug Synonyms:

Dasatinib (JAN/INN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
1969	EPHA2	4
3845	KRAS	2
55252	ASXL2	1
1387	CREBBP	1
4851	NOTCH1	1
25937	WWTR1	1
4300	MLLT3	1
472	ATM	1
3418	IDH2	2
1029	CDKN2A	1
3932	LCK	1
6794	STK11	1
3791	KDR	1
4921	DDR2	15
6389	SDHA	1
162979	ZNF296	2
1441	CSF3R	12
2071	ERCC3	1
4089	SMAD4	1
3417	IDH1	2
1956	EGFR	1
5156	PDGFRA	4
673	BRAF	4
3485	IGFBP2	2
867	CBL	4
8821	INPP4B	1
1493	CTLA4	1
2067	ERCC1	1
2194	FASN	1
3815	KIT	41
5054	SERPINE1	2
4893	NRAS	1
25	ABL1	41
4763	NF1	2

Gene in drug-gene network: Network Plot

Models in Dasatinib

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.