ATM


Summary: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ATM serine/threonine kinaseMIM:607585Ensembl:ENSG00000149311HGNC:HGNC:795PA6111q22.3

GO terms in ATM


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000723telomere maintenance
BPIEAGO:0000724double-strand break repair via homologous recombination
BPTASGO:0000729DNA double-strand break processing
BPIEAGO:0001541ovarian follicle development
BPIEAGO:0001666response to hypoxia
BPIEAGO:0001756somitogenesis
BPISSGO:0002331pre-B cell allelic exclusion
BPIEAGO:0002377immunoglobulin production
BPTASGO:0006260DNA replication
BPIBAGO:0006281DNA repair
BPTASGO:0006303double-strand break repair via nonhomologous end joining
BPIDAGO:0006468protein phosphorylation
BPIMPGO:0006468protein phosphorylation
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIMPGO:0006974cellular response to DNA damage stimulus
BPIDAGO:0006975DNA damage induced protein phosphorylation
BPIMPGO:0006975DNA damage induced protein phosphorylation
BPTASGO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BPIMPGO:0007050cell cycle arrest
BPIMPGO:0007094mitotic spindle assembly checkpoint
BPTASGO:0007131reciprocal meiotic recombination
BPIEAGO:0007140male meiotic nuclear division
BPIEAGO:0007143female meiotic nuclear division
BPTASGO:0007165signal transduction
BPIEAGO:0007420brain development
BPIEAGO:0007507heart development
BPIEAGO:0008340determination of adult lifespan
BPIEAGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:0009791post-embryonic development
BPIDAGO:0010212response to ionizing radiation
BPIMPGO:0010506regulation of autophagy
BPIEAGO:0016572histone phosphorylation
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIMPGO:0030889negative regulation of B cell proliferation
BPIGIGO:0032210regulation of telomere maintenance via telomerase
BPISSGO:0032212positive regulation of telomere maintenance via telomerase
BPIEAGO:0033129positive regulation of histone phosphorylation
BPIEAGO:0033151V(D)J recombination
BPIEAGO:0035264multicellular organism growth
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPIMPGO:0036289peptidyl-serine autophosphorylation
BPIEAGO:0042159lipoprotein catabolic process
BPTASGO:0042981regulation of apoptotic process
BPIMPGO:0043065positive regulation of apoptotic process
BPIMPGO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediator
BPIEAGO:0043525positive regulation of neuron apoptotic process
BPIEAGO:0045141meiotic telomere clustering
BPIDAGO:0046777protein autophosphorylation
BPIMPGO:0046777protein autophosphorylation
BPIEAGO:0048538thymus development
BPIEAGO:0048599oocyte development
BPIEAGO:0051402neuron apoptotic process
BPIMPGO:0051972regulation of telomerase activity
BPIDAGO:0071044histone mRNA catabolic process
BPIDAGO:0071480cellular response to gamma radiation
BPIDAGO:0071481cellular response to X-ray
BPIDAGO:0071500cellular response to nitrosative stress
BPIMPGO:0072434signal transduction involved in mitotic G2 DNA damage checkpoint
BPIMPGO:0090399replicative senescence
BPIMPGO:0097694establishment of RNA localization to telomere
BPICGO:0097695establishment of protein-containing complex localization to telomere
BPTASGO:1900034regulation of cellular response to heat
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPIEAGO:1903626positive regulation of DNA catabolic process
BPIEAGO:1903978regulation of microglial cell activation
BPIMPGO:1904262negative regulation of TORC1 signaling
BPIMPGO:1904354negative regulation of telomere capping
BPIMPGO:1904358positive regulation of telomere maintenance via telomere lengthening
BPIMPGO:1904884positive regulation of telomerase catalytic core complex assembly
BPIEAGO:1905843regulation of cellular response to gamma radiation
CCIDAGO:0000781chromosome, telomeric region
CCICGO:0000784nuclear chromosome, telomeric region
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIEAGO:0005819spindle
CCIEAGO:0031410cytoplasmic vesicle
CCIDAGO:1990391DNA repair complex
MFIEAGO:0003677DNA binding
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004677DNA-dependent protein kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0016301kinase activity
MFIMPGO:00163031-phosphatidylinositol-3-kinase activity
MFIDAGO:0044877protein-containing complex binding
MFIDAGO:0046983protein dimerization activity
MFIDAGO:0047485protein N-terminus binding

Gene expression in normal tissue: ATM

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ATM


DatabasePathway IDPathway Des.
reactomeR-HSA-1474165Reproduction
reactomeR-HSA-1500620Meiosis
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559586DNA Damage/Telomere Stress Induced Senescence
reactomeR-HSA-3371453Regulation of HSF1-mediated heat shock response
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-349425Autodegradation of the E3 ubiquitin ligase COP1
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5633008TP53 Regulates Transcription of Cell Death Genes
reactomeR-HSA-5685938HDR through Single Strand Annealing (SSA)
reactomeR-HSA-5685942HDR through Homologous Recombination (HRR)
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693537Resolution of D-Loop Structures
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693548Sensing of DNA Double Strand Breaks
reactomeR-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
reactomeR-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5693568Resolution of D-loop Structures through Holliday Junction Intermediates
reactomeR-HSA-5693571Nonhomologous End-Joining (NHEJ)
reactomeR-HSA-5693579Homologous DNA Pairing and Strand Exchange
reactomeR-HSA-5693606DNA Double Strand Break Response
reactomeR-HSA-5693607Processing of DNA double-strand break ends
reactomeR-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchange
reactomeR-HSA-6796648TP53 Regulates Transcription of DNA Repair Genes
reactomeR-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
reactomeR-HSA-6803207TP53 Regulates Transcription of Caspase Activators and Caspases
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-6804757Regulation of TP53 Degradation
reactomeR-HSA-6804760Regulation of TP53 Activity through Methylation
reactomeR-HSA-6806003Regulation of TP53 Expression and Degradation
reactomeR-HSA-69473G2/M DNA damage checkpoint
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69541Stabilization of p53
reactomeR-HSA-69563p53-Dependent G1 DNA Damage Response
reactomeR-HSA-69580p53-Dependent G1/S DNA damage checkpoint
reactomeR-HSA-69601Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
reactomeR-HSA-69610p53-Independent DNA Damage Response
reactomeR-HSA-69613p53-Independent G1/S DNA damage checkpoint
reactomeR-HSA-69615G1/S DNA Damage Checkpoints
reactomeR-HSA-69615G1/S DNA Damage Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-912446Meiotic recombination
biocartaarfpathwaytumor suppressor arf inhibits ribosomal biogenesis
biocartaatmpathwayatm signaling pathway
biocartaatrbrcapathwayrole of brca1 brca2 and atr in cancer susceptibility
biocartacdc25pathwaycdc25 and chk1 regulatory pathway in response to dna damage
biocartachemicalpathwayapoptotic signaling in response to dna damage
biocartag1pathwaycell cycle: g1/s check point
biocartag2pathwaycell cycle: g2/m checkpoint
biocartap53hypoxiapathwayhypoxia and p53 in the cardiovascular system
biocartaplk3pathwayregulation of cell cycle progression by plk3
biocartarbpathwayrb tumor suppressor/checkpoint signaling in response to dna damage
pidatm_pathwayATM pathway
pidbard1pathwayBARD1 signaling events
piddeltanp63pathwayValidated transcriptional targets of deltaNp63 isoforms
pide2f_pathwayE2F transcription factor network
pidfanconi_pathwayFanconi anemia pathway
pidnfkappabcanonicalpathwayCanonical NF-kappaB pathway
pidp38_mkk3_6pathwayp38 MAPK signaling pathway
pidp53regulationpathwayp53 pathway
pidtelomerasepathwayRegulation of Telomerase
kegghsa03440Homologous recombination - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
pharmgkbPA165948566Metformin Pathway, Pharmacodynamic
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP1545miRNAs involved in DNA damage response
wikipathwaysWP1742TP53 Network
wikipathwaysWP179Cell Cycle
wikipathwaysWP186Homologous recombination
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2516ATM Signaling Pathway
wikipathwaysWP2942DDX1 as a regulatory component of the Drosha microprocessor
wikipathwaysWP34Ovarian Infertility Genes
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
wikipathwaysWP3657Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex
wikipathwaysWP3808TP53 Regulates Transcription of DNA Repair Genes
wikipathwaysWP3878ATM Signaling Network in Development and Disease
wikipathwaysWP3959DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM
wikipathwaysWP3982miRNA regulation of p53 pathway in prostate cancer
wikipathwaysWP4016DNA IR-damage and cellular response via ATR
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP707DNA Damage Response
wikipathwaysWP710DNA Damage Response (only ATM dependent)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD150RITA3
iGMDRD532Olaparib10
iGMDRD79Gemcitabine1
iGMDRD583LDN 1931891
iGMDRD523Cyanoquinoline, 114
iGMDRD330BRD41324
iGMDRD324CI-10401
iGMDRD123Isoevodiamine5
iGMDRD945ML2142
iGMDRD722AZD67382
iGMDRD883CIL55A1
iGMDRD698Neratinib1
iGMDRD314Tanespimycin3
iGMDRD705Nakiterpiosin3
iGMDRD289Parthenolide4
iGMDRD213SMR0000686503
iGMDRD137Indisulam6
iGMDRD158NSC1415405
iGMDRD5Tyrphostin AG 14782
iGMDRD402AKT Inhibitor VIII1
iGMDRD871BRD63683
iGMDRD377Compound 1b1
iGMDRD67PENFLURIDOL3
iGMDRD286Nsc 6328392
iGMDRD892DNA-PKc inhibitor3
iGMDRD662JQ-12
iGMDRD427ABT7373
iGMDRD1Nicotin-Amide1
iGMDRD549Ibrutinib (PCI-32765)1
iGMDRD781Sirolimus9
iGMDRD483SCH-5290742
iGMDRD409Saracatinib1
iGMDRD126Tipifarnib3
iGMDRD420Leucascandrolide A7
iGMDRD394BX-7952
iGMDRD679Bistramide A7
iGMDRD466Chaetocin5
iGMDRD470Trametinib1
iGMDRD61Kinetin riboside3
iGMDRD52Rotenone2
iGMDRD44Temozolomide4
iGMDRD474Avrainvillamide3
iGMDRD431NU-74411
iGMDRD23Gossypol6
iGMDRD399Selumetinib5
iGMDRD74Idarubicin3
iGMDRD133Lapatinib1
iGMDRD188Piperlongumine5
iGMDRD888Compound 443
iGMDRD506Fedratinib2
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD160Cis-Platin3
iGMDRD116CD4371
iGMDRD307Manumycin A3
iGMDRD827ATR inhibitor3
iGMDRD595PLX40321
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD279Istradefylline1
iGMDRD536PLX-47201
iGMDRD178MG-1321
iGMDRD57Chloropentafluorobenzene2
iGMDRD351GW843682X6
iGMDRD434BMS-5369246
iGMDRD6AM-5803
iGMDRD124Canertinib1
iGMDRD881CHK1/2 inhibitor1
iGMDRD246NPC262
iGMDRD300Tozasertib10
iGMDRD505Pevonedistat1
iGMDRD353PD03259011
iGMDRD80Irinotecan1
iGMDRD239Dasatinib1
iGMDRD144NSC953972
iGMDRD971PARP inhibitor4
iGMDRD494Neopeltolide5
iGMDRD772BRD47701
iGMDRD1008SR-II-138A1
iGMDRD401Afatinib2
iGMDRD280CYTOCHALASIN B2
iGMDRD253Vincaleukoblastine1
iGMDRD201SKI II3
iGMDRD446LY 21832403
iGMDRD608Refametinib1
iGMDRD193Fqi12
iGMDRD718Pyrvinium pamoate1
iGMDRD782DC-45-A26
iGMDRD138PX 122
iGMDRD480KU00606481
iGMDRD60Quinoclamine2
iGMDRD473GDC-08791
iGMDRD398Sepantronium2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATM

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