SERPINE1
Summary: This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serpin family E member 1 | MIM:173360 | Ensembl:ENSG00000106366 | HGNC:HGNC:8583 | PA261 | 7q22.1 |
GO terms in SERPINE1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0002020 | protease binding |
| MF | IBA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | IDA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | TAS | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| BP | IEP | GO:0001300 | chronological cell aging |
| BP | IEP | GO:0001525 | angiogenesis |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | TAS | GO:0007623 | circadian rhythm |
| BP | IDA | GO:0010469 | regulation of signaling receptor activity |
| BP | IDA | GO:0010757 | negative regulation of plasminogen activation |
| BP | IMP | GO:0010757 | negative regulation of plasminogen activation |
| BP | IBA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | IDA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | IDA | GO:0014912 | negative regulation of smooth muscle cell migration |
| BP | IMP | GO:0030194 | positive regulation of blood coagulation |
| BP | IC | GO:0030195 | negative regulation of blood coagulation |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | IDA | GO:0030336 | negative regulation of cell migration |
| BP | IMP | GO:0032757 | positive regulation of interleukin-8 production |
| BP | IDA | GO:0033629 | negative regulation of cell adhesion mediated by integrin |
| BP | IMP | GO:0035491 | positive regulation of leukotriene production involved in inflammatory response |
| BP | TAS | GO:0042730 | fibrinolysis |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | TAS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0048260 | positive regulation of receptor-mediated endocytosis |
| BP | IGI | GO:0050729 | positive regulation of inflammatory response |
| BP | IGI | GO:0050829 | defense response to Gram-negative bacterium |
| BP | IDA | GO:0051918 | negative regulation of fibrinolysis |
| BP | IGI | GO:0061044 | negative regulation of vascular wound healing |
| BP | IC | GO:0061045 | negative regulation of wound healing |
| BP | IMP | GO:0071222 | cellular response to lipopolysaccharide |
| BP | HEP | GO:0071277 | cellular response to calcium ion |
| BP | IMP | GO:0090026 | positive regulation of monocyte chemotaxis |
| BP | IMP | GO:0090399 | replicative senescence |
| BP | IDA | GO:0097187 | dentinogenesis |
| BP | IDA | GO:1901331 | positive regulation of odontoblast differentiation |
| BP | IMP | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IDA | GO:2000098 | negative regulation of smooth muscle cell-matrix adhesion |
| BP | IMP | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| CC | IDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0031093 | platelet alpha granule lumen |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| CC | IDA | GO:0062023 | collagen-containing extracellular matrix |
| CC | IDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: SERPINE1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SERPINE1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian gene expression |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2173793 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| reactome | R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| reactome | R-HSA-3000178 | ECM proteoglycans |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75205 | Dissolution of Fibrin Clot |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| biocarta | fibrinolysispathway | fibrinolysis pathway |
| biocarta | plateletapppathway | platelet amyloid precursor protein pathway |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04610 | Complement and coagulation cascades - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| pid | e2f_pathway | E2F transcription factor network |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | hif2pathway | HIF-2-alpha transcription factor network |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | p73pathway | p73 transcription factor network |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| pid | upa_upar_pathway | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| wikipathways | WP15 | Selenium Micronutrient Network |
| wikipathways | WP1533 | Vitamin B12 Metabolism |
| wikipathways | WP176 | Folate Metabolism |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP272 | Blood Clotting Cascade |
| wikipathways | WP2755 | Transcriptional activity of SMAD2-SMAD3-SMAD4 heterotrimer |
| wikipathways | WP3355 | BMAL1-CLOCK,NPAS2 activates circadian gene expression |
| wikipathways | WP3614 | Photodynamic therapy-induced HIF-1 survival signaling |
| wikipathways | WP3668 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
| wikipathways | WP3896 | Dengue-2 Interactions with Complement and Coagulation Cascades |
| wikipathways | WP3897 | Dengue-2 Interactions with Blood Clotting Cascade |
| wikipathways | WP3982 | miRNA regulation of p53 pathway in prostate cancer |
| wikipathways | WP558 | Complement and Coagulation Cascades |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD146 | Elesclomol | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD454 | JNK Inhibitor VIII | 1 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD700 | AUY922 | 1 |
| iGMDRD33 | Entinostat | 1 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD573 | GSK-1904529A | 1 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD890 | CR.1.31B | 1 |
| iGMDRD608 | Refametinib | 1 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD97 | Bexarotene | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD283 | Bosutinib | 1 |
| iGMDRD484 | Pluripotin | 1 |
| iGMDRD354 | Midostaurin | 1 |
| iGMDRD239 | Dasatinib | 2 |
| iGMDRD119 | Temsirolimus | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD946 | ML320 | 1 |
| iGMDRD179 | Shikonin | 1 |
| iGMDRD472 | PF-562271 | 1 |
| iGMDRD438 | Elocalcitol | 1 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD504 | Obatoclax | 1 |
| iGMDRD459 | RO-3306 | 2 |
| iGMDRD396 | AS601245 | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD192 | CIL56 | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD450 | JNJ-26854165 | 1 |
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD404 | PD318088 | 1 |
| iGMDRD50 | Cytarabine | 1 |
| iGMDRD232 | FTI-277 | 1 |
| iGMDRD1036 | X17AAG | 1 |
| iGMDRD160 | Cis-Platin | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SERPINE1
CLASSFICATION
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